Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Volume Transmission"”.
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Connectomics of extrasynaptic signalling: applications to the nervous system of Caenorhabditis elegans
… chemical signalling via extrasynaptic volume transmission is also critical to brain function. As these interactions are not visible in the physical structure of the nervous system, current approaches to connectomics are unable to capture them. This work addresses the problem of missing …
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Sources and Targets of Trophic Factors in the Avian Locus Coeruleus and Oculomotor System
… routes. One is through axonal transport (wiring transmission), such as axons, dendrites and synapses; the other is through fluid diffusion (volume transmission), such as extracellular fluid, cerebrospinal fluid, and plasma.In addition, cells in the nervous system can receive trophic signals from …
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Building and characterising the neuropeptidergic connectome of Caenorhabditis elegans
… which primarily act through extrasynaptic volume transmission. Neuromodulation is critical to nervous system function in all species, yet little is known about the structure and function of extrasynaptic signalling networks at a whole-organism level. Here I present data and analysis for a …
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Activity Dependent Trans-synaptic Tracing Of Neural Circuits In Drosophila
… of choice. Tango-Map is designed to detect volume transmission of a neuromodulator by measuring the signal intensity of the reporter before and after a neuromodulatory effect. Furthermore, deciphering the circuit mechanisms that translate into complex behaviors will provide an understanding …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
… in the hippocampus by suppressing glutamatergic transmission. If manipulated, the NPY system may be capable of restoring the imbalance between excitation and inhibition occurring in the epileptic brain. Indeed, emerging evidence has established a proof-of-principle for viral vector-mediated …