Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Voltage-gated proton channel"”.
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Functional and Structural Studies of the Human Voltage-Gated Proton Channel
<p>The activity of voltage-gated cation channels underlies the action potentials that allow for neuronal signaling and muscle contraction. The canonical family of voltage-gated K<sup>+</sup>, Na<sup>+</sup> and Ca<sup>2+</sup> channels has been the subject of extensive electrophysiological, …
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The HV1 proton channel of Lingulodinium polyedrum localizes to the bioluminescent scintillon
… and colleagues predicted the existence of a proton selective channel that opens in response to depolarizing voltage (H<sub>V</sub>1) across the vacuole membrane of bioluminescent dinoflagellates and conducts protons into specialized luminescence compartments (scintillons), thus causing the pH …
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Engineering Hv1 Channel Mutations and Targeted Drug for Treatment of Hv1 Mutation Associated with Cancer
The voltage-gated proton channel Hv1 is crucial for maintaining cellular pH homeostasis by regulating proton movement across membranes, playing a vital role in acid extrusion and intracellular pH regulation. Dysregulation of Hv1 is associated with various diseases, including cancer, where it helps …
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I) Hv1, LBP and LCF reconstitution in Liposomes II) Signed, Sealed, and Delivered: CPP Technology Delivers Active Protein Cargo
… Binding Protein (LBP), Luciferase (LCF), voltage-gated proton channel (Hv1), as well as the substrate Luciferin (LH<sub>2</sub>). Bioluminescence is triggered by an internal drop in pH of the scintillon initiated by the voltage activation of Hv1 in the membrane. The first focus of this …
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Conformation of Transmembrane Segments of a Protein by a Coarse Grain Model
<p>The human voltage-gated proton channels (hH<sub>V</sub>1) are critical in many physiological functions and control proton conduction in the cell. This process is governed by the cooperative response of different transmembrane segments of the protein. It is believed that the two subunits of the …