Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Voltage-gated ion channels"”.
-
Evolution of Voltage-gated Ion Channels
<p>Voltage-gated Ion Channels (VICs) form a superfamily of energy-independent membrane transporters that facilitate the transfer of charged sodium, calcium, and potassium ions across the cell membrane (Hodgkin & Huxley 1952). The channels contain a selective ion-conducting pore along with several …
-
Understanding Voltage -Gated Ion Channels via Molecular Archeology
… molecular genetic and physiological experimentation have allowed better understanding towards voltage-gated ion channels. The voltage-gated ion channels (VIC) superfamily is one of the oldest groups of membrane transporters. Members of the VIC superfamily are capable of transporting potassium, …
-
Oligodendrocyte precursor cell states and their regulation
… throughout life, allowing the formation of myelin during early development, but also following learning or demyelinating injuries. A number of factors are thought to regulate OPC proliferation and differentiation, including neuronal activity, which OPCs can sense and respond to …
-
Dynamics and Model of the Pore-Forming Protein Lysenin
… are a class of membrane proteins that function to provide a pathway across a cell membrane for the movement of ions and biomolecules. Investigations into the regulatory mechanism of these systems are hindered by their extensive preparation requirements compounded by their fragility and …
-
Travelling waves modulated by resonant currents in laterally-inhibited grids of leaky integrate-and-fire neurons
… as well as at smaller scales, linked to functions as diverse as visual processing, motor coordination, and situating oneself in space. The simple analytical description of travelling waves have made them a popular lens through which to examine the dynamics of both neural field models and …
-
Dynamical mechanisms of neural firing irregularity and modulation sensitivity with applications to cochlear implants
… auditory-nerve fibers depends upon the stimulation rate. Whereas fibers fire regularly at low stimulation rates, the same fibers fire irregularly at high rates. The irregularity observed at high stimulation rates has been attributed to noise caused by the random open and closing of voltage-gated …
-
Sensory Transduction in Enteroendocrine Cells
… sensing of luminal nutrients is a central function of the gut epithelium where enteroendocrine cells act as sensor cells to secrete hormones in response to the luminal contents. This thesis focuses on voltage gated ion channels and the transient receptor potential (TRP) superfamily in I cells …
-
Statistical theory of selectivity and conductivity in narrow biological ion channels : studies of KcsA
Biological ion channels are essential for maintaining life, and appear as a seemingly paradoxical combination of both large conductivity and strong selection between ionic species. This process involves many complicated interactions, and their inclusion in a multi-species conduction model remains a …
-
Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel
"Members of the superfamily of voltage-gated ion channels are the molecular components underlying electrical excitability in nerves and muscle. Voltage-gated channels allow the selective flow of ions across the hydrophobic lipid bilayer of a cell, opening and closing in response to changes in the …
-
Changes in the Morphology of Hypoglossal Motor Neurons in the Brainstem of Developing Rats
… changes in neurotransmitters, receptors, excitation-inhibition balance, and breathing. However, age-dependent morphological changes of XII MNs during the first three weeks post-birth and especially during this sensitive period, have not been thoroughly studied. In this study, we comprehensively …
-
Canais iônicos na epilepsia : aspectos fisiopatológicos e terapêuticos
… involved. Data from the World Health Organization indicate a epilepsy worldwide prevalence in about 50 million people. In Brazil, studies on the epilepsy epidemiological aspects are scarce, however, based on the latest census and worldwide prevalence, it is assumed that almost 2 million people …
-
Defined populations of inner ear progenitor cells show limited and distinct capacities for differentiation into hair cells, neurons, and glia
… and neurons. This work reveals the differentiation capabilities of distinct inner ear progenitor populations and pinpoints cell types that can become cochlear hair cells, vestibular hair cells, neurons, and CNS glia. We expanded and differentiated cochlear and vestibular progenitors from mice …
-
Electric Fields: A Metric for Molecular-level Understanding of Protein Mechanisms
… mechanisms at the origin of protein function remains a challenge due to the complex non-covalent interactions that shape their structure. Since the non-covalent interactions arise from charge fluctuations, electric fields can be used as a tool to quantify the interactions between a target …
-
Calcium Channel Dysfunction in Huntington’s Disease
… degenerative disease that is caused by an expansion mutation in the huntingtin protein that lengthens a naturally occurring trinucleotide CAG repeat in exon 1 resulting in striatal degeneration. The mechanism by which striatal neurons undergo selective degeneration is not fully understood, …
-
Molecular Basis of Mechanosensitivity
<p>Mechanosensation is arguably the least understood of all senses. For most physiological processes, the first response to membrane stress is thought to be the opening or closing of mechanosensitive channels, but the clonal nature of the first mechanotransducers is still largely unknown. The …
-
Targeting Ion Channels to Distal Dendrites
Neurons are divided into functional compartments: the soma houses the DNA and transcriptional machinery, the axons conduct action potentials, presynaptic boutons transmit synaptic signals, and dendrites receive and integrate synaptic information. These functional differences are achieved by …
-
Biologically inspired materials for electro-responsive coatings and the photo-oxidation of water
Evolving out of research on biomineralization, a new field devoted to studying the interactions between inorganic materials and proteins is emerging. In natural systems, proteins are responsible for the assembly of complex hierarchical structures such as the nacre of abalone. Tools such as phage …
-
A modeling study of the history-dependence of conduction delay in unmyelinated axons
Conduction delay in an axon is the time required for an action potential to propagate between two positions. It is a function of the axon's passive membrane properties, voltage-gated ion channels and the Na+/K+ pump, and can be substantially affected by neuromodulators. The conduction delay of …
-
The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… fail to properly heal resulting in non-union. A need exists for a more comprehensive understanding of the complex biology of fracture repair, which involves the coordinated work of many cell types including osteoblasts, osteoclasts, and immune cells. Depending on the extent of injury, …
-
Characterization of cardiac IKs channel gating using voltage clamp fluorometry
Voltage-gated ion channels make up a superfamily of membrane proteins involved in selectively or non-selectively conducting charged ions, which can carry current in and out of cells, in response to changes in membrane voltage. Currents carried by ion channels influence the voltage across the cell …
Page 1 of 2