Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Voltage-gated Ca2+ channels"”.
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Functional properties and Ca2+-dependent feedback modulation of voltage-gated Ca2+ channels in glutamatergic nerve terminals of the mammalian auditory brainstem
… Arbeit wurden funktionelle Eigenschaften sowie Ca2+-abhängige feedback -Modulation der präsynaptischen spannungsabhängigen Ca2+-Kanäle (VGCCs) untersucht. Zu diesem Zweck wurden patch-clamp-Messungen an zwei Typen von großen glutamatergen Nervendigungen im auditorischen Stammhirn der Maus den …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
… transients in intracellular free Ca2+ concentration ([Ca2+]i) and currents were investigated in neonatal rat intracardiac neurons using fura-2 photometry and patch-clamp recordings. Extensive preliminary tests using fura-2 containing solutions in the presence or absence of the …
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Investigating the protective effects of farnesol formations against neuroinflammation
… that acts as a potent blocker of neuronal voltage-gated Ca2+ channels (L- and N-type) and is found in the human brain. FOL has potent anti-oxidant and antiinflammatory effects in vitro and is neuroprotective in a murine model of neurotoxicity. Because inflammation and neurodegeneration are …
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The role of Hedgehog signalling in T cell effector function
… of non-canonical Hh signalling through L-type voltage-gated Ca2+ channels that acts downstream of the TCR to induce activation of transcription factor Gli1 to control CD8+ T cell killing. This is in contrast to the canonical Hh signalling pathway, which this thesis shows to be important in …
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
Voltage-gated Ca2+ channels (CaV) are key regulators of excitation-contraction coupling in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
… of murine CTLs in vitro and revealed that L-type voltage-gated Ca2+ channels (Cav1) are crucial for Gli1 induction. However, the role of Gli1 in the context of cytotoxic CTL function in vivo has not been explored. Furthermore, expression and functional relevance of GLI transcription factors in …
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Regulation of SNARE-Mediated Synaptic Vesicle Release by Synaptotagmins and Complexins
… arrives at the presynaptic terminal, and induces Ca2+ influx through voltage-gated Ca2+ channels. The SNARE (Soluble N-ethylmaleimide-sensitive-factor Attachment Protein Receptors) complex is the core component of the fusion machinery in the presynaptic terminal, as it forms a physical bridge …
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Structural Studies of Complexin/SNARE Interactions
… presynaptic active zone of nerve terminals. The Ca2+-triggered release process is extremely fast, lasts less than half a millisecond, and is tightly regulated by Ca2+. Action potentials cause Ca2+ influx through voltage-gated Ca2+ channels, which in turn triggers synaptic vesicle fusion. The …
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The role of plant extracts on islet function in vivo and in vitro
… showed that OSA® and CP elevated intracellular Ca2+ concentrations ([Ca2+]i) in Fura-2-loaded β-cell, an effect which was completely abolished by the removal of extracellular Ca2+ or blockade of voltage-gated Ca2+ channels (VGCC). These in vitro observations suggest that one mode of action of …
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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons
… of these bursts. One of these mechanisms is the Ca2+-dependent afterhyperpolarization (AHP), which activates during bursts and causes spike frequency adaptation. This afterhyperpolarization has three distinct conductances: a fast component (fAHP) underlain by BK channels, a medium component …
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Characterization of Rimonabant effects on G protein activity
… mitogen-activated protein kinase (MAPK), inhibit voltage gated Ca2+ channels and activate inwardly rectifying K+ channels (Howlett et al., 2000; Pertwee, 2010). The first selective and potent CB1 antagonist Rimonabant (also known SR141716A, SR) at high micromolar concentrations behaves as an …
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Funktionelle Charakterisierung neu gebildeter Körnerzellen im Gyrus dentatus des Hippokampus
… werden, was darauf hinweist, dass es durch T-Typ-Ca2+-Kanäle erzeugt wurde. Die T-Typ-Ca2+-Kanäle waren auch daran beteiligt, dass in jungen Zellen ein sehr kleiner Strom ausreichte, um Na+-Aktionspotentiale auszulösen. Ca2+-Konzentrationsmessungen zeigten, dass sowohl das langsame Ca2+-Potential …