Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Voltage-dependent calcium channel"”.
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Molecular Interactions and Physiological Function of the Voltage-Dependent Calcium Channel Gamma6 Subunit
In Chapter I, I give an overview of the Voltage-dependent Calcium Channel (VDCC) and its importance as a key regulator of intracellular calcium. I attempt to provide a thorough explanation of the nomenclature system used to describe the various VDCC subunits, and discuss the structure and …
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Development of blocking antibodies to the voltage-gated calcium channel cav3.2
T-type voltage-dependent calcium channel Cav3.2 is a four-domain channel participating in various physiological and pathological processes principally in the nervous system but also in non-excitable cells. Upregulation of Cav3.2 or mutations in this channel are found in pain syndromes, certain …
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Calcium and growth hormone secretion in the domestic fowl (Gallus domesticus)
Extracellular calcium is a ubiquitous molecule required for secretagogue induced growth hormone release from somatotroph cells of the chicken anterior pituitary. Growth hormone release can be induced via different intracellular pathways and these in turn can act to produce a synergistic hormone …
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Mnemonic Representations of Transient Stimuli and Temporal Sequences in the Rodent Dentate Gyrus In Vitro
… driven by NMDAR and L- and T-type voltage-dependent calcium channel conductances, driving persistent synaptic barrages onto hilar cells. These barrages last for 10s of seconds, resembling the persistent activity observed in vivo during working memory tasks. In this dissertation, I …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
… modeling, we focused our research on cyclin dependent kinase 2 (CDK2) and glycogen synthase kinase-3β (GSK-3β). We prepared a non-redundant database from 303 available CDK2 PDB structures. We removed all structural anomalies and proceeded to use the CDK2 database in studying CDK2 structure in …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… in the ability of morphine to maximally inhibit voltage dependent calcium channel activity recorded from FC and control neurones. <br/><br/>The findings of this study emphasize the need to investigate both male and female mice as there are differences in the effects of FC on body weight and gene …
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The interaction of ELKS with Ca2+ channel β subunits may contribute to active zone organization
… matrix of the active zone (CAZ) and synaptic voltage-dependent calcium channels (VDCCs) are both required for the organization and regulation of synaptic vesicle release. Here we report a novel interaction between the CAZ protein family ELKS and VDCC β subunits. We found that two isoforms of …