Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Vitronectin"”.
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
… of host complement down-regulatory protein vitronectin. This interaction delayed the formation of the membrane attack complex on the bacterial surface and increased the bacterial serum-resistance. Furthermore, we identified a novel surface-exposed virulence factor designated Haemophilus …
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The Role of Silicates in Interstitial Lung Disease
… metabolite. Prostacyclin release was Cox 2 and vitronectin receptor (VNR) mediated. Coating crocidolite asbestos with vitronectin enhances its internalization via VNR, which also recognize the Arg-Gly-Asp (RGD) motif present in a variety of ligands (e.g., vitronectin, fibronectin). These …
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The Role of Silicates in Interstitial Lung Disease
… metabolite. Prostacyclin release was Cox 2 and vitronectin receptor (VNR) mediated. Coating crocidolite asbestos with vitronectin enhances its internalization via VNR, which also recognize the Arg-Gly-Asp (RGD) motif present in a variety of ligands (e.g., vitronectin, fibronectin). These …
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Haemophilus influenzae adhesins and the innate immune response
… interactions with innate defense mechanisms. Vitronectin is a glycoprotein that regulates the terminal pathway of the complement system by inhibiting the membrane attack complex. We demonstrate that Haemophilus influenzae surface fibrils (Hsf) may increase the bacterial survival by interacting …
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Elucidating the Ferritin-High Molecular Weight Kininogen Domain 5 Interaction
… HK5 disrupts the interaction between uPAR and vitronectin, which activates the uPAR signaling pathway. Inhibiting the vitronectin–uPAR interaction causes an inhibition of endothelial cell adhesion, migration, tube formation and proliferation as well as inducing apoptosis. The minimum …
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Cells, surfaces and adhesion
… adhesion proteins, demonstrating the presence of vitronectin and fibronectin on the lenses. The second experimental chapter addresses divalent cation regulation of integrin mediated cell adhesion. Several cell types and various cations are used. Zinc, previously not regarded as an important cation …
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Cellular interaction with novel biomaterials
… A33, A37, A38, A42, A43, A44. The presence of vitronectin in the ocular tissue appears to lead to higher cell adhesion to the posterior surface of a contact lens when compared to the anterior surface. Group IV contact lenses adhere more cells than Group II contact lenses - this may indicate …
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Structure-activity relationships of PAI-1 inhibitors
… III, and/or fail to inhibit PAI-1 when vitronectin, a cofactor of PAI-1 is present. The synthesis of small-molecule inhibitors of PAI-1 that improve upon these properties has been the main goal of this research. Research efforts focused on examining changes in inhibitor potency based on …
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
… expressed by encapsulated H. influenzae, binds vitronectin, a regulator of the terminal pathway of the complement system. Mapping of the membrane bound Hsf with gold-labelled specific antibodies in transmission electron microscopy (TEM) revealed a double-folded 100 nm long fibrillar structure. …
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Immunological and biochemical techniques in the analysis of tear proteins
… of the ubiquitous cell adhesion glycoprotein, vitronectin, in tears and contact lens wear under various parameters. Vitronectin, whose levels are known to increase in the closed eye environment and shown here to increase during contact lens wear, is an important immunoregulatory protein and may …
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
… identified role of the matricellular ECM protein vitronectin was discovered, responsible for regulating bladder cancer cell proliferation through integrin αVβ5 mediated mechanisms which contributed to loss of p27 and rapid progression through the cell cycle. Although deregulation of the cell cycle …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… lesion environment by exposing cultured OPCs to vitronectin and BMP4 is sufficient to induce a SC fate within one week of induction. OPC-derived SCs morphologically and transcriptionally resemble primary SCs, and when transplanted into the CNS can survive and myelinate host CNS axons with …
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A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
… HMW-FDPs resulted in no change in protection. Vitronectin also did not appreciably affect tPA inhibition by PAI-1. Pg, in conjunction with HMW-FDPs, decreased the k2 for tPA inhibition by 30-fold. Hence, Pg, when bound to HMW-FDPs, protects tPA by an additional 10-fold. TAFIa treatment of the …
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In vitro Untersuchungen zur Wirkung von Saccharidmimetika auf verschiedene Schritte der Metastasierung von malignen Melanomzellen
… der B16F10-Zellen an Fibronectin (40 %), Vitronectin (50 %) und Laminin (50 %) signifikant zu reduzieren. Der Furanring als Grundgerüst der Saccharidbibliothek bietet dabei den Vorteil, daß das Saccharidmimetikum über eine Diels-Alder-Reaktion an Fluoreszenz-Farbstoffe gekoppelt werden …
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Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair
… scaffolds. We systematically adsorb fibronectin, vitronectin, and collagen ECM proteins to alter surface adhesiveness and measure MSC migration responses of speed and directional persistence alongside intracellular activities of EGFR, ERK, Akt, and FAK phosphoproteins. While tEGF and ECM proteins …
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Pericyte and Endothelial Cell Responses within Murine Cerebral Capillaries After Blood Flow Cessation
ABSTRACT The microcirculation, encompassing terminal arterioles, capillaries, and venules, plays a pivotal role in the distribution of blood throughout tissues, with capillaries acting as the primary sites for oxygen and nutrient delivery as well as waste product removal. A critical component of …
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The detection of occult metastatic disease in patients with cutaneous melanoma
… these antibodies blocked the binding of PAI1 to vitronectin and inhibited the activity of the inhibitor. Finally, two of these Mabs turned out to be extremely valuable and were used to develop a novel microtiter plate assay for measuring the active fraction of PAI1 in biological fluids by making …