Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Visium"”.
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Profiling the dynamics of the active transcriptome in the juvenile and adult brain using spatial transcriptomics
… of the tissue samples. The 10x Genomics Visium Spatial gene expression system was used to obtain genome-wide spatial gene expression patterns. The Visium FASTQ files were aligned to the human transcriptome using 10X Genomics SpaceRanger. To spatially map the brain cell types, the Visium …
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Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration
… single nuclei RNA-sequencing (snRNA-seq) and 10X Visium spatial transcriptomics (Chapter 2). I first investigated cortical neuron vulnerability using snRNA-seq (Chapter 3). Upper motor neurons (herein called L5 ETs: layer 5 extratelencephalic-projecting excitatory neurons) were expected to display …
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Integration of Spatial Transcriptomics with Chromatin Images Using Graph-Based Autoencoder Identifies Joint Biomarkers for Alzheimer’s Disease
… technologies, such as STARmap and 10x Visium, allow the joint measurement of these different modalities in whole tissue sections.1,2 However, methods for jointly analyzing the different spatial data modalities in 3D are still lacking. We present a computational framework to integrate …
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Single-cell atlasing of the human tissues across the lifespan
… and proteomic technologies, focusing on Visium and IBEX. Next, I provide an overview of the prenatal and postnatal periods of development, followed by a more in depth discussion on causes of human ageing. Finally, I conclude with a description of the main events and functional changes in …
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Computational profiling of the tumour immune microenvironment
… TME. Additionally, the application of the 10x Visium platform provides new spatial perspectives on TME features, underlining both the utility and limitations of current methodologies. In summary, this thesis advances our understanding of the TME through bioinformatic innovation but also offers …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
<p>Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An …