Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Visceral pain"”.
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Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… proportion of the population. Abdominal pain is a major clinical symptom, but current treatments are limited and a source of frustration for patients, many of whom seek alternatives such as cannabis. Cannabis contains many compounds with therapeutic potential that do not have the …
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Targeting pro-inflammatory mediators to treat visceral pain
Visceral pain is a prominent cause of morbidity in gastrointestinal (GI) diseases, like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), but many current analgesics produce GI side effects. To develop much needed, novel treatments, further understanding of the pro-inflammatory …
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Investigating novel therapeutic targets for treatment of visceral pain.
Abdominal pain is a common symptom of gastrointestinal disorders such as Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). However, despite the many treatments for inflammation in IBD and disordered motility in IBS patients, few therapies target abdominal pain directly, and many …
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A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
Chronic abdominal pain is a major cause of patient morbidity in inflammatory bowel diseases (IBD). A balance of pro- and anti-nociceptive factors regulating colonic dorsal root ganglion (DRG) neurons, which synapse onto second order dorsal horn neurons, are known to regulate chronic pain but the …
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The comparative efficacy of inhaled methoxyflurane and intranasal fentanyl for the pre hospital management of cardiac and or visceral pain
… and intranasal Fentanyl for the management of pain of cardiac or viscera/ aeitology and to secondly assess the usefulness of an alternative pain assessment tool utilised by the WA Ambulance Service. DESIGN: Retrospective study. PARTICIPANTS: Patients suffering pain of a cardiac or visceral pain …
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Neurochemical drivers of visceral pain: insights into the roles of interleukin-17 and the proton-sensing G protein-coupled receptor GPR68
… disease (IBD) often experience severe abdominal pain that remains poorly managed due to limited therapeutic options and the gut-related side effects of conventional analgesics. My thesis addresses this unmet clinical need by investigating inflammatory mediators and mechanisms that drive pain in …
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Novel insights into early life stress-induced dysfunction of the gut-brain axis
Visceral pain, a debilitating hallmark of disorders of gut-brain axis interactions such as irritable bowel syndrome, has a major impact on quality of life. Given the increasing prevalence of irritable bowel syndrome over the past number of years, as well as a lack of effective treatments for …
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Expression and Function of Galanin in Colonic Sensory Neurones
… sensations arising from the GI tract, such as pain. In particular, the distal colon is a key source of visceral pain in both inflammatory bowel disease (e.g. ulcerative colitis and Crohn’s disease) and irritable bowel syndrome. In both conditions, pain relief is complicated by the GI side …
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The effects of di (2-ethylhexyl) phthalate (dehp) on lesion development in a mouse model of endometriosis
… and 35%–50% of women experiencing chronic pelvic pain and/or infertility. The most widely accepted mechanism of this disease is the entry of endometrial cell aggregates into the peritoneal cavity via the fallopian tubes in a process known as retrograde menstruation. These endometrial fragments …
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Neuroepithelial Signalling in the Colon
Abdominal pain is the leading cause of morbidity for people living with gastrointestinal diseases, however pain management remains an unmet clinical challenge. TRPV4 is a member of the vanilloid subtype of transient receptor potential ion channels and possesses pronociceptive functions in the …