Global ETD Search
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Showing 1 to 19 of 19 for “"Visceral leishmaniasis"”.
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Arsenic, antimony and visceral leishmaniasis
… rate of antimonial compounds in the treatment of visceral leishmaniasis (VL) has declined from over 85% to less than 50%. This has been attributed to prolonged, widespread misuse of antimonials within the Indian private healthcare system. An alternative resistance hypothesis is that exposure to …
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Antibody Dependent Enhancement of Visceral Leishmaniasis
Leishmaniasis is a parasitic disease caused by protozoans of the genus <em>Leishmania</em>. This vector-born disease, transmitted by biting phlebotomine sandflies, typically manifests in one of three ways. The cutaneous form of the disease is characterized by localized lesions of the skin and is by …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
Visceral leishmaniasis, caused by infection with the intracellular protozoan Leishmania donovani, is a chronic disease that affects the spleen, liver and bone marrow. Patients present with high parasite burdens in visceral organs, splenomegaly, cachexia, pancytopenia and will progress to death if …
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The Use of Geographic Information Systems and Ecological Niche Modeling to Map Transmission Risk for Visceral Leishmaniasis in Bahia, Brazil
Leishmaniasis is a public health problem in Brazil, and despite the control programs in place, Bahia remains one of the states with the highest incidence rates of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). This study proposed to develop and evaluate the applicability of …
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Analysis and robust simulation of mathematical models of HIV and Leishmaniasis co-infection
… and numerical study of epidemiological models of Visceral Leishmaniasis (VL) and human immunode ciency virus (HIV) coinfection. We study these models theoretically and design and analyze robust numerical methods to solve them. The rst sub-model describes the transmission dynamics of VL and …
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Non-ionic surfactant vesicles as an Amphotericin B inhaled delivery system for the treatment of leishmaniasis
Amphotericin B (AmB) is a drug used to treat visceral leishmaniasis and fungal infections. Current available AmB formulations are limited by instability at tropical temperature, parenteral administration, renal toxicity (Fungizone®) or cost (AmBisome®, Amphotec® and Abelcet®). In this study, …
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Translating biomedical research data to knowledge through bioinformatics
… golden hamster transcriptomics data during visceral leishmaniasis, we discovered that splenic macrophages experienced mixed classic and alternative polarization/activation and whole spleen tissue experienced massive inflammatory response during visceral leishmaniasis. We proposed several …
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The role of vector-derived microbiota and co-localization in the dissemination of vector transmitted pathogens
Visceral Leishmaniasis poses significant challenges to prophylactic vaccination and treatment strategies due to the ability of Leishmania spp. parasites to disseminate from the initial site of infection in the skin to the internal organs following transmission by the bite of an infected sand fly …
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Development of non-ionic surfactant vesicles for inhaled drug delivery
… of AmB-NIVs was able to supress the progress of visceral leishmaniasis in vivo with larger particles being superior to smaller sizes (p ≤ 0.05 in the liver and spleen). Incursion of hydroxypropyl-γ-cyclodextrin (HPγCD), rather than sucrose (p ≤ 0.01), protected empty-NIVs when freeze-dried and …
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Dendritic cell regulation of immunity to Leishmania donovani
… immunopathology and chronic immune suppression, visceral leishmaniasis is endemic to some of the world’s most resource-poor regions. There is no vaccine and current therapeutic options are limited by parasite resistance, high toxicity and prohibitive costs. As such, a deeper understanding of the …
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Chemical synthesis of <em>Leishmania </em>lipophosphoglycan structures conjugated to a biotin moiety
Leishmaniasis is the second largest parasitic killer in the world (after malaria) responsible for an estimated 500,000 cases each year worldwide. Visceral leishmaniasis infections (i.e. internal organs) are more complicated to diagnose due to the lack of visible symptoms. Current tests of the …
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Influência das condições de cultivo na produção de antígenos recombinantes de Leishmania i. chagasi utilizando Escherichia coli M15 cultivada em incubador rotativo e biorreator
… prophylaxis capable of preventing leishmaniasis. As such, there is a great need to identify specific antigens for the development of vaccines and diagnostic kits against visceral leishmaniasis. Thus, the primary goal of the present study is to assess the influence of cultivation …
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Ecological risk models for visceral leishmaniais [sic] in Bahia, Brazil and diagnosis of Trypanosoma cruzi infection in dogs in south central Louisiana
… predict the distribution and potential risk of visceral leishmaniasis (VL) in the State of Bahia, Brazil. The objective was to define the environmental suitability of the disease as well as to obtain a deeper understanding of the eco-epidemiology of VL by associating environmental and climatic …
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Characterization of Canine Leishmaniasis in the United States: Pathogenesis, Immunological Responses, and Transmission of an American Isolate of Leishmania infantum
… infantum, an etiologic agent of zoonotic visceral leishmaniasis, has recently emerged in the foxhound population in the United States and parts of Canada. Leishmania infections are usually spread to mammals by infected sand flies, however epidemiological data do not support a role for sand …
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Estudo da modulação da migração de células hospedeiras induzida por Leishmania e seu impacto na disseminação do parasito no hospedeiro
… humans. The diseases caused by this protozoan, leishmaniasis, can present different clinical manifestations, from localized skin lesions that heal spontaneously, to disseminated skin lesions, mucocutaneous form of the disease, and visceral leishmaniasis, the most severe form that can lead to …
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Characterising the bacterial microbiota of Phlebotomus and Glossina insects : vectors of parasitic diseases
… on the pathogens they carry. Trypanosomiasis and leishmaniasis are neglected tropical diseases caused by kinetoplast parasites and transmitted between human hosts by biting flies. In this thesis the bacterial microbiota of tsetse flies and sand flies, the vectors of trypanosomiasis and …
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Studies using luciferase-expressing Leishmania donovani parasites
Visceral leishmaniasis is a life threatening illness that affects 12 million people worldwide and 350 million people across 88 countries are at risk of infection. The disease is caused by Leishmania donovani, a parasite transmitted by the female sand fly. Resistance to the drugs used to treat the …
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Aspectos ambientais e sociais envolvidos na transmissão da L. chagasi no município de Parnamirim/RN
Visceral leishmaniasis hás adapted in the past 20 years to periurban and urban areas, and in Natal, Rio Grande do Norte, it became endemic. Thid study aimed to evaluate the environmental and social aspectsof Leishmania chagasi infection and its epidemiologic transmission chain in an urban, …
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Spontaneous Raman spectroscopy: Exploring applicability in drug discovery and the medical sciences
… Raman Spectroscopy (SERS) for research on Visceral Leishmaniasis (VL) and Leishmania donovani as well as investigating applicability for cancer research are decisive parts of this work.<br/><br/>The key work described in this thesis is the investigation of whole cell concentration of …