Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Virus shedding"”.
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
Human rotavirus (HRV) is a major causative agent of acute gastroenteritis (AGE), which causes severe dehydrating diarrhea in children under the age of five and results in up to 215,000 deaths worldwide each year. There are two live oral attenuated vaccines licensed for use in the United States that …
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Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
… difficile (C. difficile) and human rotavirus (HRV) are leading causes of bacterial and viral gastroenteritis worldwide. Treatment and vaccination options for both pathogens have significant limitations. C. difficile infections are treated with antibiotics, which is paradoxical as C. …
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Cross-protection and Potential Animal Reservoir of the Hepatitis E Virus
… swine HEV became infected as evidenced by fecal virus shedding and viremia, and the majority of pigs also developed IgG anti-HEV prior to challenge at 12 weeks post-inoculation. After challenge, viremia and fecal virus shedding of challenge viruses were not detected, suggesting that prior …
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Cross-Species Infection and Characterization of Avian Hepatitis E Virus
… and capsid gene regions. Recovery of identical viruses from the experimentally inoculated chickens in the subsequent transmission study further confirmed our field results. The capsid gene of avian HEV isolates from chickens with HS syndrome were also characterized and found to be heterogeneic, …
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Development and Characterization of A Recombinant Orf Virus Vector Expressing the Spike Protein of Porcine Epidemic Diarrhea Virus
<p>Orf virus (ORFV), the type member of the genus <em>Parapoxvirus</em> of the family <em>Poxviridae</em>, causes orf or cutaneous pustular dermatitis in sheep and goats. ORFV is a ubiquitous virus capable of re-infecting its hosts multiple times over time. ORFV causes a non-systemic, self-limiting …
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Characterization of structure and dynamics of membrane proteins from solid-state NMR
… and C-terminal cytoplasmic domain of influenza A virus M2 and 2) HIV-1 glycoprotein gp4l membrane-proximal external region and transmembrane domain (MPER-TMD) in a near native membrane environment. The cytoplasmic domain of M2 is necessary for membrane scission and virus shedding. The M2(22-71) …
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Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
Human rotavirus (HRV) and human norovirus (HuNoV) are the most common causative agents of acute gastroenteritis- (AGE) related morbidity and mortality around the world. Gnotobiotic (Gn) pigs are the ideal large-animal model that allows for accurate, and precise, preclinical evaluation of vaccine …
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Within Host and Multiscale Models of Usutu and SARS-CoV-2 Viral Infections with Animal Hosts
… explores the relationship between within-host virus dynamics, the environment and the between-host viral transmission. We will validate the models against data from SARS-CoV-2 infections, and data from infections with an emerging pathogen, the Usutu virus. Our models of SARS-CoV-2 infection …
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Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
Norovirus and rotavirus are the most common viral causes of acute gastroenteritis among all age groups and in children under 5 years of age, respectively. Understanding the pathogenesis of the virus and correlates of protective immunity is fundamental to developing effective prevention and …
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INTERSPECIES TRANSMISSION AND HOST RESTRICTION OF INFLUENZA A VIRUSES
Type A influenza viruses can infect both mammals including humans, pigs, horses, cats, dogs, ferrets, and sea mammals as well as domestic and wild birds. Although influenza A viruses shows host range restrictions, interspecies transmission have been documented at many occasions. Swine have been …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
… have utilized samples from healthy or influenza virus infected subjects from 8 distinct populations in 5 countries to conduct an integrative analysis of the unique and interactive effects of age (biological), herpesvirus serostatus (environmental), and genetics on variation in basal immunity and …
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Mechanism of Pathogenesis and Replication of an Avian Strain of the Hepatitis E Virus in a Chicken Model
… animal model system to study this important virus. The objectives of this dissertation were to utilize chickens as a model system to study the pathogenesis and replication of avian HEV under the natural route of infection, to identify potential extrahepatic replication sites, to determine and …
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The host-pathogen interactions of Chinook Salmon (Oncorhynchus tshawytscha) and the aquatic rhabdoviral pathogen infectious hematopoietic necrosis virus
Infectious hematopoietic necrosis virus (IHNV) is an aquatic rhabdovirus that causes acute disease in Pacific salmon and trout populations in aquaculture facilities and freshwater conservation hatcheries across the northern hemisphere. While disease occurs primarily in juvenile fish, assessment of …
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Understanding the Role of the Hypervariable Region in the Open Reading Frame 1 of the Hepatitis E virus in Viral Replication
Hepatitis E virus (HEV) is a major cause of enterically transmitted acute viral hepatitis in developing countries that lack proper hygienic infrastructure. Hepatitis E is globally distributed and has emerged as an important public health disease in both developing and industrialized countries. HEV …