Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Virus binding"”.
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
Vaccinia virus (VV) is the prototypical member of the orthopoxvirus genus of the Poxviridae family, and is currently being evaluated as a vector for vaccine development and cancer cell-targeting therapy. Despite the importance of studying poxvirus effects on the human immune system, reports of the …
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Analysis of the role of lipids in retrovirus transduction
… used in gene therapy protocols are mammalian virus vectors. Specifically, retroviruses are one of the most common viral vectors used since they are able to permanently integrate their transgene into the host cell genome, providing, in principal, to a long-term cure. The potential applications …
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Assembly and detection of viruses and biological molecules on inorganic surfaces
… optimized and consensus sequences were achieved. Virus binding was characterized using Atomic Force Microscopy, Fluorescene Microscopy and Titration. Using a simple bimolecular model, the binding sequence identified through this work is shown to have a binding constant 100,000 times better than a …
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The Role of Adaptor Protein Grb2 in Ecotropic Retrovirus Entry and Receptor Trafficking
For retroviruses such as HIV-1 and murine leukemia virus (MLV) active receptor recruitment and trafficking occur during viral entry. However, the underlying mechanisms and cellular factors involved in the process are largely uncharacterized. The viral receptor for ecotropic murine leukemia virus …
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In vitro and In vivo Characterization of the Infection Efficiency of a Modified Retrovirus Envelope Glycoprotein for Targeting Gene Transduction
… these two components influence the efficiency of virus infection in in vitro and in vivo systems with an emphasis on characterizing the transduction capacity of a novel entry-targeting glycoprotein. In previous work, the Moloney murine leukemia virus (MLV) envelope glycoprotein (Env) was modified …
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Structural Basis of Bat and Raccoon Dog Angiotensin-Converting Enzyme 2 (ACE2) Receptor Recognition by Sarbecoviruses
… of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This dissertation investigates the molecular basis of receptor recognition in two species relevant to the emergence of COVID-19: the horseshoe bat (Rhinolophus sinicus) as a potential natural host and the raccoon dog …
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Cross-protection from St. Louis encephalitis virus and Usutu virus disease by human West Nile virus convalescent plasma in mice
West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), and Usutu virus (USUV) are emerging mosquito-borne flaviviruses. These viruses are phylogenetically closely related and belong to the Japanese encephalitis serocomplex group. Similar to other flaviviruses, these viruses are enveloped, …
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Analysis, Optimization and Application of AAV Capsid Assembly using Escherichia coli
Recombinant adeno-associated viruses (rAAV) are leading drugs in gene therapy with three products approved by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA). Currently, rAAV vectors are evaluated in many ongoing clinical trials for treating rare genetic diseases and …
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Studies of the interaction of hepatitis B virus with human haemopoietic cells.
… aspects of the interaction of hepatitis B virus (HBV) with haemopoietic cells and cell lines, to address the reported tropism of HBV for haemopoietic tissues. Emphasis was directed at demonstrating specific attachment of HBV to defined subpopulations of peripheral blood leucocytes (PBL) and …
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Effects of galectins and antibodies in HIV infection; Novel Assays
… mediating neutralization and inhibition of virus induced cell-cell fusion. In a multicenter study, Neutnet II, the assay compared well with other neutralization assays and was suggested to be an alternative to the traditional peripheral blood monocyte (PBMC)-based assay and the TZMbl assay. …
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The interaction between NS1B protein of influenza B virus and the ubiquitin-like modifier ISG15 : insights into a unique species specific property of the virus
Influenza B virus causes a respiratory disease in people with a compromised immune system. The NS1B protein of influenza B virus is essential for virus growth and plays a crucial role in inhibiting the anti-viral responses mounted by the infected host cell. The N terminal 104 amino acids of NS1B …