Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Virulence determinants"”.
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Identification of the virulence determinants of the neonatal meningitic bacterium Cronobacter sakazakii
… source which may have a role in the organism’s virulence. The presence of sialic acid utilization genes could be relatively recent evolution, as high levels of sialic acid are accessible to bacteria in intestinal mucosa and the brain. Another important finding was, the presence of a number of …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… generated and screened in order to identify AIEC-virulence determinants specifically involved in pTh17 generation, looking for mutants with an impaired ability to trigger the secretion of the polarizing cytokines IL-23/IL-1β, by human dendritic cells (DCs), linked to pTh17 differentiation. Our …
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Identification of virulence determinants of Mycobacterium tuberculosis via genetic comparisons of a virulent and an attenuated strain of Mycobacterium tuberculosis.
Candidate virulence genes were sought through the genetic analyses of two strains of Mycobacterium tuberculosis, one virulent, H37Rv, one attenuated, H37Ra. Derived from the same parent, H37, genomic differences between strains were first examined via two-dimensional DNA technologies: …
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Defining genomic drivers of evolution in the entomopathogenic Serratia spp. A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… candidate for future biocontrol approaches. Virulence determinants for both chronic and hypervirulent isolates reside on variants of a megaplasmid, pADAP (amber-disease associated plasmid), which encodes the Afp (antifeeding prophage) and Sep-Toxin complex. Pathogenic isolates of both species …
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Characterization of a novel virulence determinant in Erwinia carotovora subspecies atroseptica SCRI1043
… Gram-negative bacteria, producing virulence factors, such as plant cell wall degrading enzymes {PCWDEs), which enable the initiation and maintenance of host plant invasion. rsmS was shown to encode a short polypeptide, and it has orthologues in many Gramnegative agriculturally and …
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Novel extracellular products of Mycobacterium tuberculosis: composition, synthesis, and relevance to disease
… identification and characterization of Mtb virulence determinants is required. Specifically, biosynthetic routes for these virulence determinants should be pursued. Furthermore, the interaction between the host and Mtb virulence determinants should be characterized at a molecular level. It …
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A Multiepitope Subunit Vaccine for Enterotoxigenic Escherichia Coli (ETEC) Expressing LT, STA, STB, and STX2E Toxins
… toxin Stx2e, produced by ETEC strains are the virulence determinants in porcine ETEC-associated diarrhea. These enterotoxins enzymatically disrupt fluid homeostasis in pig small intestinal epithelial cells that leads to fluid and electrolyte hyper-secretion and diarrhea. A protective antitoxin …
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Molecular typing of virulence genes in enterotoxigenic Bacillus cereus
… and 101 cfu/ml. In order to detect the multiple virulence determinants in pathogenic B. cereus, specific primers were used to target three enterotoxigenic genes (hblC, nheA, and hblA), followed by melt-curve analysis to confirm identity. Conditions used for this experiment allowed for the …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
… Relatively little is known regarding the virulence mechanisms of B. pseudomallei; however, several putative virulence determinants have been identified. The organism is able to invade and replicate within phagocytic cells and is particularly pathogenic in males with diabetes mellitus. B. …
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Regulating Campylobacter jejuni flagellar gene expression: transcriptional and post-transcriptional mechanisms of control
… developed world. C. jejuni flagella are crucial virulence determinants, but the regulation of these complex organelles within different environments is not fully understood. Moreover, regulatory RNAs are important for virulence and flagellar gene expression in many prokaryotes, but their role in …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… the pleiotropic activity of specific AIEC virulence determinants to assess whether their simultaneous targeting can prevent the cascade of pathogenic events leading to chronic inflammation. To this aim, we generated and functionally characterized single and double mutants in the LF82 …
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Pleiotropic regulatory function of the lysr family transcriptional regulator cpsy during streptococcus iniae systemic infection
… the local environment for optimal expression of virulence determinants is a continued area of research. Orthologs of the <i>Streptococcus iniae</i> LysR family regulator CpsY have been shown to regulate methionine biosynthesis and uptake pathways, but appear to influence expression of several …
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Relative contributions of the stringent response mediators (p)ppGpp and DksA to Haemophilus ducreyi virulence in humans
… stringent response is required for H. ducreyi virulence in humans. A ΔrelAΔspoT mutant, which is unable to synthesize (p)ppGpp, was partially attenuated for abscess formation in human volunteers. Loss of (p)ppGpp increased bacterial resistance to phagocytosis and stationary phase survival; …
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Characterisation and secretion mechanism of Bordetella pertussis autotransporter proteins
The identification and characterisation of new virulence determinants of 5. pertussis is providing important information for understanding the colonisation and survival strategies of the microorganism. B. pertussis deploys a range of surface-associated components to enable its successful …
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The Effect of Environment on Virulence Factors and Resistance of Mucoid Strains of Pseudomonas Aeruginosa
… Both showed differences in the production of the virulence factors, protease, elastase, lipase, phospholipase C and pyocyanine and fluorescent pigments under different nutrient limitations. Growth conditions also affected exopolysaccharide production by M7. In general, phosphate and iron …
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Development and Evaluation of a Multiplex Suspension Array Protocol for the Detection of Enteric Pathogens from Clinical Specimens
… parvum, Entamoeba histolytica) and six virulence determinants of shiga toxin-producing Escherichia coli (STEC), enterotoxigenic Escherichia coli (ETEC), enteroinvasive Escherichia coli (EIEC) and Shigella spp. Precision and limits of detections were established for both assays. The …
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CHARACTERIZATION OF CA²⁺-MEDIATED VIRULENCE AND MICROBIAL COMPETITION IN THE PLANT PATHOGEN PSEUDOMONAS SYRINGAE
… to fine-tune their physiology and coordinate virulence.Pseudomonas syringae, a model bacterial plant pathogen, uses a sophisticated arsenal of virulence factors, including the type III secretion system (T3SS), virulence factors, and phytotoxins, to manipulate plant cellular processes and …
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Identification and characterisation of proteases in Mycobacterium tuberculosis
Virulence determinants of M. tuberculosis remain largely unknown. Of key interest has been the ability of the bacterium to survive intracellularly within its host cell, the macrophage, and its ability to cause extensive tissue necrosis. Exported proteases are commonly associated with virulence in …
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Post-transcriptional regulation of vibrio cholerae virulence activator toxt
… a complex array of gene regulation to induce its virulence determinants. During the early stage of infection, and upon response to unknown signals, virulence genes are turned on. ToxT protein is the primary virulence gene transcription activator. Once ToxT is produced, it amplifies its own …
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The emergence of <i>Escherichia coli</i> with CTX-M extended-spectrum beta-lactamases in the United Kingdom
… and compared, as were their phylogenetic and virulence backgrounds. The genetic support and environment of the various <sup><i>bla</i></sup><sub>CTX-M</sub> genes were also investigated.<br></br><br></br> The multi-drug resistance of <i>E. coli</i> with CTX-M enzymes was principally encoded by …
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