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Showing 1 to 20 of 62 for “"Virulence Gene"”.
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Identification of the virulence gene of Mycobacterium tuberculosis
… is to identify and characterize potential virulence genes from M. tuberculosis. To this end, we have compiled and integrated information from various public databases to catalogue 246573 microbial genes from 84 organisms, including pathogens and non pathogenic microbes. We determined the …
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
… that RtsA increases expression of the invasion genes by inducing hilA expression. RtSA also induces expression of hilD, hilC, invF, and slrP. RtsA induction of these genes is independent of other SPI1 regulators. RtsA directly induces hilA expression by binding to the promoter. We propose that …
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The transcriptional control of virulence gene expression in Helicobacter pylori
… to obtain an overview of the basic mechanisms of virulence gene expression in H. pylori, three important virulence factors of this pathogen, representative of different pathogenic mechanisms and different phases of the infectious process, are investigated in detail in the present thesis regarding …
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<i>Staphylococcus aureus</i> virulence gene studies : a comparative microarray based approach
… of a partial composite <i>S. aureus</i> virulence-associated gene micro array is described. Epidemic, pandemic and sporadic lineages of healthcare associated(HA-) and community-associated (CA-) <i>S. aureus</i> were compared. The clonal population structure was supported but further …
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Roles of Small Rnas and Paralogous Proteins In Bacillus Anthracis Virulence Gene Regulation
… a myriad of regulatory mechanisms to control gene expression. One of the most common mechanisms is post-transcriptional control through the function of small regulatory RNAs (sRNAs). Small regulatory RNAs (sRNAs) are short transcripts that base-pair to mRNA targets or interact with regulatory …
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Virulence gene expression of three hypervirulent S. pyogenes M1T1 and membrane vesicles isolation
… activity against S.pneumoniae and S.pyogenes and a potent capacity of adhesion to HEp-2 cells. The main aim of this study was to evaluate the clinical evidence of a probiotic application of S.salivarius 24SMBc for the prevention or reduction of recurrent medium otite (OM) children …
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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
… infections is due in part to the arsenal of virulence factors <italic>P. aeruginosa</italic> has at its disposal, which include biofilm formation, lipopolysaccharide, quorum sensing, and exotoxin production, among others. AmrZ, a member of the ribbon-helix-helix family of DNA binding …
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CONTRIBUTIONS OF SIGMA-B AND PRFA TO STRESS RESPONSE AND VIRULENCE GENE EXPRESSION IN LISTERIA MONOCYTOGENES
… food borne bacterial pathogen Listeria monocytogenes has several mechanisms for regulating expression of stress response and virulence genes. The alternative sigma factor sigmaB is a global regulator of genes active under environmental stress conditions and during stationary phase growth. I …
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The Mechanism For Inhibition Of Vibrio Cholerae Virulence Gene Expression By Bile And Its Fatty Acid Components
… diarrheal disease cholera by producing two major virulence factors: cholera toxin (CT) and toxin-coregulated pilus (TCP). During infection, <i>V. cholerae</i> downregulates its motility genes, which are actively expressed in the environment, and upregulates its virulence genes, which are inactive …
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Effects of low molecular weight compounds on growth, virulence gene expression and cytotoxic activity of Shiga toxin-producing Escherichia coli O157:H7
… compound (LMWC) capable of inhibiting various virulence gene expressions in E. coli O157:H7 has been identified, which could help mitigate its pathogenicity at certain time points in its infection. Our own previous studies showing significant down-regulation of virulence gene expression in …
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How did Listeria monocytogenes become pathogenic?
… been clearly resolved due to a scarcity of phylogenetically informative characters within the 16S and 23S rRNA molecules. The genus Listeria contains six species: L. monocytogenes, L. ivanovii, L. innocua, L. seeligeri, L. welshimeri, and L. grayi; of these, L. monocytogenes and L. ivanovii are …
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Studies Toward the Syntheses of Antiarrythmic, Anti-Virulence, and Anticancer Small Molecules
… of potent inhibitors of QseC mediated virulence gene expression, and c) studies toward a biomimetic total synthesis of nigricanoside A. Antiarrhythmic analogs of 17(R),18(S)-epoxyeicosatetraenoic acid (17(R),18(S)-EEQ): Arrhythmias such as atrial and ventricular fibrillation are a …
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Characterization of the grvA and grvB Anti -Virulence Genes Encoded by the Gifsy-2 and Gifsy -1 Bacteriophages of Salmonella Typhimurium
… contribute significantly to S. typhimurium virulence. We have been studying biology of these phage to determine the effects of Gifsy-1 and Gifsy-2 on the virulence of S. typhimurium. The Gifsy-2 phage carries the periplasmic superoxide dismutase gene, sodCI. Using the IVET system, we …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the SPI1 regulatory circuit. The …
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CcpA-Mediated Carbon Catabolite Repression of Virulence in the Group A Streptoccus
… The coordinate expression of a wide array of virulence factors in response to the changing host environment represents a key step in the ability of the GAS to mediate disease in the human host. The present study investigates the role of the primary mediator of sugar metabolism regulation, …
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The Influence of The Pep-Pts and Other Metabolic Systems On The Master Virulence Regulator Atxa and to xin Gene Expression In Bacillus Anthracis
<p>AtxA, the master virulence gene regulator in <em>Bacillus anthracis,</em> is a PRD-containing virulence regulator (PCVR) as indicated by the crystal structure, post-translational modifications, and activity of the protein. PCVRs are transcriptional regulators, named for the regulatory domains …
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Functional Similarity of Prd-Containing Virulence Regulators In Bacillus Anthracis
… regulators, AtxA, AcpA, and AcpB, that control virulence gene expression and are members of an emerging class of regulators termed “PCVRs” (Phosphoenolpyruvate-dependent phosphotransferase regulation Domain-Containing Virulence Regulators). AtxA controls expression of the toxin genes; <em>lef, …
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Epidemiología molecular de Staphylococcus spp. desde un enfoque One Health: genes emergentes e inusuales de resistencia a antibióticos y de virulencia
… emergent and unusual antibiotic resistance and virulence genes. Staphylococcus spp. isolates recovered from tracheal samples of 242 wild birds were characterized. SCoP were recovered from 8.3% of wild birds tested, and the isolates were identified as S. aureus (n=9) and S. delphini (n=12). Most …
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Characterization of major virulence regulators of Erwinia amylovora
… type III secretion system (T3SS) are two major virulence factors in E. amylovora. However, how these virulence factors are regulated is not completely understood. In bacteria, gene expression is mainly regulated at the transcription initiation level and its core RNA polymerase (RNAP) requires …
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Determination of the occurrence, virulence genes, and antimicrobial resistance profiles of enterococcus faecalis and enterococcus faecium isolated from poultry of Chongwe, Lusaka, Kitwe, and Ndola districts, farmworkers from the Copperbelt province poultry farms and clinical specimens from Kitwe teaching hospital in Zambia.
Enterococcus has great genetic plasticity and is highly versatile, hence does not only acquire and express mobile genetic elements (MGEs) but also disseminates them to pathogenic and non-pathogenic species of the same or of different genera. As such, it has been associated with various clinical …
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