Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"Virome"”.
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Metagenomic Analyses of the Human Gut Virome
… in the USA, over the course of a year. The virome in this population was dominated by phages and exhibited high inter-personal variation and contrasting intrapersonal stability, suggesting a prevalent temperate lifestyle rather than a predator-prey relationship that is a feature of marine …
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The Virome in Primary and Secondary Immunodeficiency
The afflictions suffered by immunocompromised individuals have historically been attributed to overt infections caused by bacterial and fungal pathogens. For this reason, treatment methods have focused on resolving these infections, with great success in terms of reducing short-term morbidity and …
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Molecular characterization of faecal RNA virome of healthy chickens using next-generation sequencing
Submitted in complete fulfilment of the requirements for the degree of Master of Applied Science in Biotechnology, Durban University of Technology, Durban, South Africa, 2023.
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Characterization of Negeviruses and insect virome interactions during co-infection in cell culture
… ISVs or how they interact with the insect’s virome. It was recently demonstrated that both wild-type and genetically modified Negeviruses can inhibit the replication of Alphaviruses in mosquito cell culture. For Negeviruses to be used in wild mosquito populations they will have to compete …
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Evolutionary studies of wheat streak mosaic-associated viruses and characterization of the wheat virome
Wheat viruses including Wheat streak mosaic virus (WSMV), Triticum mosaic virus (TriMV), High Plains wheat mosaic emaravirus (HPWMoV), and Barley yellow dwarf virus (BYDV) cost substantial losses in crop yields annually. Although there have been extensive studies conducted on known wheat viruses, …
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The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
The remarkable advancements in sequencing technologies have allowed the entire mutational landscape of hundreds of different types of human cancers to be defined. This knowledge gives patients two new categories of treatment options, small molecule inhibitors and targeted immunotherapy. Veterinary …
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Detection and characterisation of enteroviruses and the gut virome in islet autoimmunity and type 1 diabetes using novel molecular methods
Type 1 diabetes (T1D) is a chronic autoimmune condition affecting over 8.4 million individuals globally. Usually preceded by islet autoimmunity (IA), T1D results from a complex interplay between host genetics and environmental factors, with virus infections, especially enteroviruses (EV) identified …
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Comparative genomic approaches for investigating evolution in the microbial and viral populations of the rumen
… conducting a survey of rumen viral metagenome (virome) and subsequent comparison of the virome and microbiome sequences to ascertain if there was genetic information shared between these populations. We hypothesize that the bacteriophages play an integral role in the community dynamics of the …
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Mosquito Communities and Insect-Specific Viruses in a Heterogenous, Urban Landscape in Puerto Rico
… in an urban setting and to characterize the virome of <em>Ae. aegypti</em> in San Juan, Puerto Rico. Mosquitoes were collected in three periods during late 2018 and early 2019 and were identified to the species level. Socioeconomic factors were measured using foot surveys and U.S. Census …
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Characterisation of bacteriophage dynamics associated with foodborne pathogens
… of this work, the emerging role of the gut virome in health and disease is reviewed, highlighting the virome as both a potential biomarker of disease and a component of microbiome shifts. Novel associations have been identified between the human gut virome and diseases such as obesity, …
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Genomic tools to investigate and characterise emerging and reemerging disease in aquatic invertebrates
… approaches were used to characterise the virome of an economically important shrimp species in the context of health and disease, and characterise a novel viral pathogen associated with mortalities of a bivalve species. I report the discovery and genomic characterisation of a novel …
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RNA bacteriophages: diversity, abundance, and applications
… has lagged behind. This viral component (virome) is dominated by bacteriophages (phages) - viruses that target and infect prokaryotes. They are intrinsically linked to the bacterial community of every ecosystem and potentially dictate the bacterial composition, function, and dynamics …
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Novel insights into fibre and lipid substrates on the microbiome
… proportion of the microbiota, the human gut virome. An extensive literature review was undertaken in Chapter 1 to examine how diet may impact colonisation resistance against invading pathogens, exploring how different food components and metabolites either protect or promote gastrointestinal …
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Exploring early-life microbiome transfer and therapeutic applications in bovines and humans
… health applications, (3) characterising the virome of bovine colostrum and the influence of perinatal factors on its composition, and (4) the potential of microbiome-based therapeutics for disease treatment in bovines and humans. Chapter 1 discusses the impact of perinatal factors, including …
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In between empathy and wonder lies the contamination that makes us human
… material--endosymbiosis; microbiome; the human virome--and affect, the moment that intrudes consciousness--empathy, wonder, or something in between. The role that the body and the gut plays in the performance of empathy with its constituent microbes is re-conceptualized by drawing from the …
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A RNA Virus Reference Database (RVRD) to Enhance Virus Detection in Metagenomic Data
… promise that metagenomics holds in exploring virome composition and discovering novel virus species, there is a pressing demand for comprehensive and up-to-date reference databases to enhance the downstream bioinformatics analysis. In this study, a RNA virus reference database (RVRD) was …
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Characterising the molecular response of Agaricus bisporus to mushroom virus X infection
… mushroom virus X (MVX). MVX constitutes a virome of 18 distinct single-stranded RNA viruses, of which select members cause detrimental disease phenotypes in infected mushrooms of A. bisporus. Scant focus has been placed on the molecular responses from the host during infection. The work …
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Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines
… elite sport, and altered diversity of the gut virome. We demonstrate that short-term combined cardiorespiratory and resistance exercise does not lead to significant reductions in the circulating inflammatory biomarker profiles of sedentary individuals or patients with stable inflammatory bowel …
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Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach
… composition. I assess the idea of a core virome as well as in what degree my data agrees with this concept.
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