Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Viral reservoir"”.
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Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
Bats are asymptomatic reservoirs for a number of viral pathogens. How they manage to host highly pathogenic viruses such a Nipah and Marburg without showing clinical symptoms remains unclear. One of the earliest defenses vertebrates use to control viral infections is the interferon response. Upon …
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Understanding and Targeting Clearance of Persistent HPV Infections
… regression. Persistent infected cells form a viral reservoir, causing disease occurrence and are particularly problematic during carcinogenesis development for high-risk types; therefore, understanding HPV-mediated epithelial homeostasis is essential for understanding disease progression. In …
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… (PHI) plays a pivotal role in establishing the viral reservoir, leading to persistent immune activation and inflammation despite combination antiretroviral therapy (cART). While cART has transformed HIV into a manageable chronic condition, it remains unable to eradicate the virus or fully …
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SARS-COV-2 EVOLUTION AND TRANSMISSION: WITHIN-HOST, BETWEEN-HOST, AND BETWEEN-SPECIES
… the temporal and mechanistic aspects of these viral changes through comprehensive genomic analyses. Specifically, we investigate the evolution of SARS-CoV-2 within immunocompromised individuals with prolonged infections, compare viral adaptations between vaccinated and unvaccinated hosts, and …
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Blood-Feeding Patterns of Eastern Equine Encephalitis Virus Bridge Vectors at Viral Foci in Southeast Georgia
… or avians. Despite an inadequate avian viral reservoir and a lack of infected mosquitoes, EEEV reemerges each spring. Therefore, other vertebrates, potentially long-lived reptiles, probably serve as the reservoir host for EEEV. This study attempts to profile the relative abundance and …
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Modeling HIV-1 Infection in the Brain: The Effect of the Blood-Brain Barrier
Despite the advancement of antiretroviral therapy (ART), the development of HIV associated neurocognitive disorders (HAND) remains a major concern among HIV infected patients. As many ART drugs may fail to penetrate the blood-brain barrier (BBB), the long-term presence of viral RNA in the brain is …
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
Bats are an incredibly diverse and abundant viral reservoir species. Their immune systems are uniquely anti-inflammatory and anti-viral, often tolerating viral infection without any signs of disease. Several pandemic and emerging viruses have been traced back to different bat species, including …
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Characterizing the cellular latent reservoir of HIV-1 and the effect of immune activation on characteristics of the reservoir
Since the advent of antiretroviral therapy (ART) and the resultant suppression of viraemia in the majority of people living with HIV-1 (PLWH) on ART, HIV-1 infection has become manageable and PLWH have similar life expectancies as uninfected persons. However, ART is not curative, is needed …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… so far due to the existence of the cellular reservoir in which the virus can reside and replicate even under antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the …
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Regulation of cellular glucose metabolism by HIV-1 infection
… survival of infected cells and low constitutive viral production, generating viral reservoirs. Our studies show that HIV-1 infection lead to significant changes in the glycolytic pathway of infected cells by altering the enzymatic activity and protein expression of various glycolytic components. …