Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Viral particles"”.
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Design and evaluation of a device for trapping hepatitis C viral particles at ultra low concentrations
A new method to quantify hepatitis C (HCV) viral particles when present in ultra low concentrations is being developed. Hepatitis C is a viral infection that affects the liver. There are 3.2 million people in the United States with an active hepatitis C infection. Untreated HCV can lead to …
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Considerations on the use of Impedance Spectroscopy for the Detection of Virions Trapped in Quadrupolar Microelectrode Arrays
… over a wide frequency range to determine whether particles captured at the center of the array could be detected impedimetrically. The microelectrode array (denoted as DEP chip) uses dielectrophoretic forces to concentrate particles at its center. Initial results showed that there was a large …
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A Three Dimensional Model of Virus Dynamics in HIV Patients
… actively infected CD4<sup>+</sup> T cells, and viral particles.</p> <p>For the model described by a three-dimensional ODE system, a bounded positively invariant set Γ in R<sup>3</sup><sub>+</sub> is found. We show that if N < N<sub><em>c</em></sub>, that is if the number of viral particles …
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Electron microscopic studies on barley yellow dwarf virus infection in oats
… The virus is transmitted by aphids that inject viral particles into the phloem of the host during the feeding process. BYDVs remain restricted to the phloem tissue and cause cytopathological alterations that ultimately lead to complete obliteration of the infected cell. Phloem cells are …
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DNA-Launched Vaccines for Emerging and Re-emerging Viral Pathogens
… the large number and increasing frequency of viral outbreaks around the globe, there is a need to address the availability, consistency, and production of vaccines. Although there are approved vaccines for some of these diseases there are still issues that face the implementation of these …
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Single-Stranded-Dna Sp6 and T7 Bacteriophage Promoter Plasmids for Engineering Mutant Rnas and Proteins: Extensions and Deletions at the Amino Terminus Which Alter the Activity of Preproparathyroid Hormone Signal Peptide
… pSP6(.)f1 or pTZ plasmids as single stranded DNA viral particles. A single species of RNA can be transcribed from these vectors due to the stringent specificity of bacteriophage T7 or SP6 RNA polymerase for their respective promoter DNA sequences. Thus, these vectors are suitable for the efficient …
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The role of human breast milk mucus and mucins in HIV-AIDS
… lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV …
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Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria
… reported to inhibit the production of infectious viral particles at concentrations which are non toxic to human cultured cells. It is speculated that this activity is associated with the decreased production of the heavily glycosylated epitope 2G 12 which is found on the gp120 glycoprotein …
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PRODUCTION OF VIRUS-FREE ORCHIDS VIA TISSUE CULTURE TECHNIQUES
… were employed in this project to eliminate the viral pathogens from the infected orchid plants: meristem culture and thin section culture with/without chemotherapy. Meristems (0.10 mm to 1.00 mm) were excised from axillary shoots of CyMV and ORSV infected Mokara Char Kuan 'Pink', a monopodial …
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Characterization and sequence variation of the virulence-associated proteins of different tissue culture isolates of African Horsesickness virus serotype 4
… The most likely AHSV proteins to be involved in viral virulence and attenuation are the outer capsid proteins, VP2 and VP5, due to their role in attachment of viral particles to cells and early stages of viral replication. Nonstructural protein NS3 may play an equally important role due to its …
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External cavity laser biosensor for label-free detection
… detecting biologically important molecules and viral particles in extremely low concentration.
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CELLULAR AND MOLECULAR PATHWAYS CONTROLLING SARS-COV2 ASSEMBLY AND EGRESS
… the ERGIC, interact with the complex formed by viral RNA and the Nucleocapsid (N) protein (ribonucleocapsid) on the cytosolic side of the membrane and form the viral particle by budding into the lumen of the ERGIC. From here, newly formed virions would be expected to enter the Golgi complex and …
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The Genomic Sequence and Annotation of Bacteriophage HK239
… is replicated, phage genes are expressed and new viral particles are assembled. Ultimately, the host cell lyses and the phage particles are released into the environment. In the lysogenic lifestyle, a phage integrates its genome into the host chromosome, creating a prophage. The cell containing …
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Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
… mediates selective internalization of the viral particles after systemic administration. We validated the internalization and transduction capabilities of the octreotide-targeted AAVP in a neuroendocrine tumor cell line expressing SSTR2. Additionally, we confirmed AAVP homing and TNF …
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Improving the effectiveness of oncolytic virotherapy: insights from mathematical modelling
Oncolytic viruses are viral particles that specifically infect cancer cells, while mostly preserving healthy tissues. Their use as cancer treatment has received considerable attention in recent years, but their clinical use still faces many challenges. Some of the main obstacles to the propagation …
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Design, Synthesis And Biological Evaluation Of Small Molecules That Inhibit Hiv-1 Entry And Sensitize Hiv-1 Infected Cells To Immune Responses
… HIV-1 infection both by sensitization of viral particles to neutralization and sensitization of HIV-1 infected cells to antibody-dependent cellular cytotoxicity (ADCC). The first part of my thesis describes the development of a late-stage derivatization strategy for the synthesis of …
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Discovery and engineering of antiviral defense systems in bacteria and archaea
… and diverse life form on Earth. With over 10³¹ viral particles in existence, viruses fundamentally shape global biogeochemistry and ecology. Most viruses infect bacteria, archaea, and other microbes, and the threat of infection continually challenges microbes' survival. As a consequence of this …
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An impulsive differential equation model for Marek's disease
… we focus on the poultry industry and a viral disease of poultry called Marek's disease. This system lends itself well to impulsive differential equations. Entire cohorts of poultry are introduced and removed from a barn concurrently. Additionally, Marek's disease is transmitted …
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Human Cytomegalovirus Us17 Locus Fine-Tunes Innate And Intrinsic Immune Responses
… ΔUS17 produced equal numbers of infectious particles in fibroblasts compared to parental virus, at equal multiplicities of infection, it produced >3-fold more genome-containing non-infectious viral particles, and delivered increased amounts of pp65 to newly infected cells. These results …
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Dissecting Host-Viral Interactons Through Focused or Unbiased High-Throughput Genetic Approaches
… thousand million million million—times as many viral particles as humans on earth (1). While most of these viruses do not cause disease in humans, those that do present a grave and increasing threat to human health. Fundamental studies in host-viral interactions are thus critical to further our …
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