Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 321 for “"Viral infection"”.
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Multiscale Modelling of Hepatic Viral Infection
The multiscale modelling of hepatic viral infection was introduced in this work and various approaches were carried out to contribute effectively to the control and eradication of viral hepatitis in sub-saharan Africa. A nested multiscale model was developed by applying the Replication-Transmission …
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Immunoepidemiological Modeling of Dengue Viral Infection
Dengue viral infection is a mosquito-borne disease with four distinct strains, where the interactions between these strains have implications on the severity of the disease outcomes. The two competing hypotheses for the increased severity during secondary infections are antibody dependent …
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Mathematical Modeling of Dengue Viral Infection
In recent years, dengue viral infection has become one of the most widely-spread mosquito-borne diseases in the world, with an estimated 50-100 million cases annually, resulting in 500,000 hospitalizations. Due to the nature of the immune response to each of the four serotypes of dengue virus, …
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Demographics of lytic viral infection of coastal ocean Vibrio
Viral predation on bacteria in the ocean liberates carbon from the particulate fraction, where it is accessible to higher trophic levels, and redirects it to the dissolved fraction, where it supports microbial growth. Although viruses are highly abundant in the ocean little is known about how their …
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UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… pregnancy, there are substantial consequences to viral infection. Following maternal infection, certain viruses can traverse the placental barrier, establish infection in the fetus, and cause adverse pregnancy outcomes or congenital disease. To combat this, the placenta has evolved potent defenses …
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The role of microvesicles in cancer and viral infection
… mode of virus transmission to secondary sites of infection has remained unclear. This study identified that Coxsackie virus B1 (CVB1) entry into HeLa cells results in apoptosis and production of virus-induced apoptotic microvesicles (vaMVs) by infected cells. Flow cytometery and fluorescence …
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Demographics of lytic viral infection of coastal ocean vibrio
Viral predation on bacteria in the ocean liberates carbon from the particulate fraction, where it is accessible to higher trophic levels, and redirects it to the dissolved fraction, where it supports microbial growth. Although viruses are highly abundant in the ocean little is known about how their …
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Defining mRNA-generated T cell memory in respiratory viral infection
… to restrict pathogen growth upon secondary infection, although the ability of T cells generated by novel mRNA-LNP vaccines to restrict viral infection in currently unknown. To address this, we studied antigen specific T cell memory generated by mRNA-LNP vaccines in both humans and mice. We …
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Early-life viral infection impacts brain development in the piglet
Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-04-01T13:13:30Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Conrad_Matthew.pdf: 3394461 bytes, checksum: f06d58c4852df172dc22c7da3068b132 (MD5)
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Redox Regulation of T cell Activation and Function During Viral Infection
… decreased in effector cells at day 8 post acute viral infection. Deletion of PrdxII increased ROI, proliferation, and death during in vitro division. Activated CD8+ T cells from PrdxII deficient mice were resistant to Fas-Ligand induced apoptosis, but susceptible to death-induced by TCR …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
… mediated diseases, and differential outcome to infection. Studies to date have suggested a role for biological, environmental, and genetic factors in immune variation; however, they are often focused on a specific subset of the population (e.g. ancestral group, age range) which can exclude …
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Diet and respiratory viral infection alter oligodendrocyte homeostasis and myelination processes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Ameliorative effects of phytochemical ingestion on viral infection in honey bees
… To date, there are no effective treatments for viral infection in honey bees and management relies largely on controlling Varroa mites, a honey bee pest capable of vectoring viruses. Plant-derived chemicals (phytochemicals) represent a broad range of substances that honey bees frequently …
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Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice
… model has sufficiently mimicked key aspects of viral pathogenesis and immune response. In this regard, new advances with humanized mice(hu-mice), constructed by engrafting human tissues and cells and harboring a functioning human immune system, have been of great value in advancing research with …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… (CTL) and natural killer (NK) cells kill virally infected and malignant cells by two major pathways, the perforin/granzyme pathway and the Fas and/or TNF death receptor pathways. In contrast to other target cells, virally infected hepatocytes are resistant to killing by perforin and …
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The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… encoded receptors that detect the products of viral replication and initiate signaling cascades leading to activation of the antiviral response. During the course of infection, many viruses produce dsRNA that can be recognized by two major arms of the innate immune system: the toll-like …
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Studies on the Mechanism of Inhibition of Tobacco-Mosaic Viral Infection by Enzymes
Made available in DSpace on 2014-12-05T20:30:11Z (GMT). No. of bitstreams: 1 6003968.pdf: 3818438 bytes, checksum: da05931e0b17e7d84860de66a3ac17f5 (MD5) Previous issue date: 1960
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The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection.
… course of a herpes simplex virus type-1 (HSV-1) infection, NK cells can influence host susceptibility to infection with severe infections occurring in individuals with genetic defects in the NK cell response. In response to HSV infection, NK cells are recruited to the inflammatory tissue where …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… studies implicate influenza A virus (IAV) infection during pregnancy as a risk factor for NDDs. To investigate this link, maternal immune activation (MIA) is often modeled using pathogen mimics, like poly I:C. While these models have provided invaluable mechanistic insights, poly I:C …
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