Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Viral immunity"”.
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
Infants are particularly vulnerable to infection and severe disease, yet we lack effective vaccines for this population. While maternal antibodies can provide protection, they also inhibit the infant’s de novo antibody response. Furthermore, maternal antibodies can exacerbate disease in some …
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Impact of anti-viral immunity on neural stem/progenitor cell activity and implications for CNS development
<p>Viral infection and inflammation in the central nervous system (CNS) can cause neuropathology, particularly in the prenatal and neonatal stages. Severe damage to the CNS may result from cytopathic effects of viral infection or from the immune response that may lyse virally-infected cells or …
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Rarely Acquired Type II-A CRISPR-Cas Spacers Mediate Anti-Viral Immunity Through the Targeting of a Non-Canonical PAM Sequence
… sequences (protospacers) to prevent infection ("immunity"). In the Streptococcus pyogenes type II-A CRISPR-Cas system, the protospacer targets on the viral genome are followed by a conserved "N-G-G" DNA motif, known as the protospacer adjacent motif (PAM). The PAM identifies the phage DNA as …
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Using network inference to discover molecular pathways underlying cytokine synergism and age-related neurodegeneration
… diverse biological phenomena ranging from anti-viral immunity to autoimmune disorders like inflammatory bowel disease (IBD). In addition, PCSF approach is applied in a cross-species context to integrate information from Drosophila models for neurodegeneration and human Alzheimer's Disease (AD) …
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Cas9-Primed Adaptive Immunity During the CRISPR-Cas Response
… variable sequences known as spacers. Following viral infection, these sequences are acquired from the viral genome and integrated in the CRISPR array as new spacers. Spacers are then transcribed into CRISPR RNAs (crRNAs) that direct the Cas nucleases to destroy the invader following …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
… OVs ability to trigger to two distinct forms of immunity simultaneously: anti-tumour and anti-viral. OV-induced anti-viral immunity typically refers to release of virions, cytokines and damage- or pathogen-associated molecular patterns (DAMPs and PAMPs) to the tumour microenvironment (TME) upon …
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Single molecule pull down of double strand RNA binding proteins
… pathways, including RNA interference, anti-viral immunity, mRNA transport and alternative splicing. However, little is known about the molecular mechanisms underlying the interaction between dsRBPs and dsRNA. Here we examined four human dsRBPs, ADAD2, TRBP, Staufen 1 and ADAR1 `which have …
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Using Genetic and Pathogeneses Studies to Develop Antiviral and BVDV Vaccine Targets
<p>Understanding bovine viral diarrhea virus (BVDV) interaction with the host may help explain the ability of the virus to cause multiple forms of disease ranging from subclinical symptoms to severe disease and even death. BVDV cytopathogenicity and onset of mucosal disease within one herd of PI …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… and vesicle transport to xenophagy and anti-viral immunity. Increasingly, however, TBK1 dysregulation has been linked to autoimmune disorders and cancers, heightening the need to understand regulatory controls of TBK1. As a result, this dissertation investigates three components of the TLR3 …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… on unrelated conditions such as allergy and autoimmunity. Additionally, helminth infections can alter susceptibility to other infections. In this thesis, we investigate the systemic influences of murine nematode Nippostrongylus brasiliensis infection on host immunity in colonized and …
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Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine
… schistosomiasis on vaccine-induced memory immunity in schoolchildren from a rural endemic area of Cameroon and in laboratory mice. As a proof of concept, a well-established anti-viral vaccination programme with wide global coverage, i.e., anti-polio vaccination, was evaluated for its …
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Deciphering Features of Protective or Maladaptive Cellular Immunity in the Airways Following Primary and Repeated Pathogen Exposure
… allergens, toxins, and microbes). Infection with viral, microbial, and eukaryotic pathogens can disrupt airway homeostasis, leading to local and systemic inflammation, which can either contribute to the clearance or persistence of the pathogen. Prior antigenic exposure - prophylactically or from a …
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A Clonal, Transcriptomic, and Functional Analysis of T-cells Mobilized to Blood in Response to Acute Exercise
… reduce the incidence of disease and boost anti-viral activity. One mechanism by which exercise enhances systemic immune function is through the redistribution of leukocytes with each exercise bout; a response that is driven by catecholamines and purported to increase host immune surveillance. …
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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications
… for a number of bacterial, fungal, and viral infections, holds that germs are a necessary but not sufficient condition for infectious disease with susceptibility determined by the genetics of individual members of the host species. In the first part of this thesis, I describe a child …
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Characterization of pro- and anti-inflammatory immune responses in SARS-CoV-2 infection
Viral infection stimulates the immune response to produce many cytokines and chemokines, the proteins imperative to fight a brewing infection. This response begins through recognition of pathogen-associated molecular patterns (PAMPs) from the virus, or from other signatures characteristic of tissue …
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The organization and evolution of heterochromatin in the Anopheles gambiae complex
… gene regulation, germline development, and anti-viral immunity. Three candidate genes associated with spermatogenesis and embryogenesis have been identified. These genes showed piRNA enrichment, and upon further analysis show up-regulation after a blood meal is taken. These genes could …
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Animal models for investigating coronavirus heterotypic immunity
… usually mild, represent the 6th leading cause of viral pneumonia. Additionally, multiple zoonotic spillovers of CoVs have occurred in the last 25 years to cause severe pneumonia, most recently the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome …
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Human Antibody Response to Flaviviruses and SARS-Coronavirus-2
<p>The last decade has seen a number of viral epidemics and global pandemic. Increased global connectivity makes the likelihood of future mass outbreaks ever greater. Understanding the adaptive immune response to these pathogens will expand basic understanding of viral immunity mechanisms and can …