Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Viral glycoprotein"”.
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Secretion of the rotavirus VP7 capsid glycoprotein from polarised epithelial cells
… the structural proteins of rotavirus, the VP7 glycoprotein forms the outer capsid layer of the virion where it is a key target for neutralising antibodies, which act to prevent virion decapsidation. Both polarised and non-polarised cell culture models have been widely used in rotavirus …
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Cofactors in Coronavirus Entry
… Enveloped viruses accomplish this task by viral glycoprotein-mediated binding to host cells and fusion of virus and host cell membranes. For the coronaviruses, viral spike (S) proteins execute these cell entry functions. In my dissertation research I focused on understanding the coronavirus …
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In vitro and In vivo Characterization of the Infection Efficiency of a Modified Retrovirus Envelope Glycoprotein for Targeting Gene Transduction
<p>Attributes of both the viral glycoprotein and its cellular receptor play key roles in determining the outcome of infection. This body of work endeavors to illustrate how these two components influence the efficiency of virus infection in in vitro and in vivo systems with an emphasis on …
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Modified Green Tea Polyphenol, Palmitoyl-EGCG and Black Tea Theaflavins: Promising Natural Herpes Simplex Virus 1 and 2 Agents
… and contain antioxidants known to possess antiviral properties, including anti-HSV (Herpes Simplex Virus). There is no cure for the diseases caused by HSV infections. While there is a rising concern over the increase in resistant HSV strains, new effective agents for prevention are in critical …
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Single Molecule Ligand Binding Studies on CCR5 by Fluorescence Cross-Correlation Spectroscopy
… major co-receptor for HIV-1. CCR5 binds to the viral glycoprotein gp120 allowing HIV particles to infect T cells. Currently, maraviroc is the only Food and Drug Administration (FDA) approved entry inhibitor for HIV-1 but resistance to maraviroc has been reported indicating the need for novel …
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DISCOVERY OF LIGNIN SULFATE AS A POTENT INHIBITOR OF HSV ENTRY INTO CELLS
… involves the cell surface heparan sulfate and glycoproteins in the viral envelope which enables the virus to penetrate into the cell. The second step is the fusion step. Depending on the nature of interaction and size of HS chain, a single chain may bind multiple viral ligands on a virion. …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
… sense unsegmented RNA viruses, leads to acute viral haemorrhagic fever with a fatality rate of greater than 50 % and is currently incurable. As such, understanding the biochemical mechanisms and molecular interactions underpinning Ebola Virus Disease represents a clearly unmet therapeutic need. …
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Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
… tegument layer. There are over fifty viral proteins and many host proteins identified in HSV-1 virions. The final formation of mature virus particles requires the membrane wrapping of tegumented capsids in the cytoplasm, a process termed secondary envelopment. This process involves the …
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Investigating the effects of pH on alphaviral E3-E2 glycoprotein association, organization, and cellular tropism
… of E1 during intracellular transport. Throughout viral processing, the association of E2 and E3 is required for the successful trafficking and incorporation of E1 into the mature virion. This E3-E2 association has been observed to extend to mature virions in the solved structure for the envelope …