Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Viral gene expression"”.
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The Epstein-Barr Virus-Encoded BHRF1 miRNAs Regulate Viral Gene Expression in Cis
… infection and latency. LCLs have a latency III gene expression profile akin to the EBV-associated tumors diffuse large B cell lymphoma (DLBCL) and post-transplant lymphoproliferative disorder (PTLD). During latency III, EBV expresses the full repertoire of latency genes including two microRNA …
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Investigating the Role of Human Cytomegalovirus Protein LUNA in Regulating Viral Gene Expression during Latency
… uncovering how HCMV causes disease. The study of viral genes that are expressed during latent infection grants insight into how latency is regulated and how it could be therapeutically targeted. To that end, this project has sought to evaluate the functional significance of one such viral gene …
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Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
… to the swine industry worldwide. Here, the viral translatome was characterised using ribosome profiling (RiboSeq), a high-throughput sequencing-based technique that allows the positions of translating ribosomes to be mapped to a genome with sub-codon precision. This was used in parallel with …
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ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ ΘΕΡΜΙΚΟΥ ΣΟΚ ΣΕ ΜΟΛΥΣΜΕΝΑ ΚΑΙ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΑΠΟ ΤΟΝΙΟ SV40
… THE ABOVE INDUCTION WAS SOMEWHAT DIFFERENT. THE GENES RESPONSIBLE FOR THE INDUCTION OF THE 70 KD FAMILY HEAT SHOCK PROTEINS WERETHE EARLY VIRAL GENES (T-ANTIGENS). THE EXPOSURE OF SV40 VIRUS INFECTED CV1 CELLS TO HEAT SHOCK OR ARSENITE RESULTED IN AN INHIBITION OF THE EARLY AND LATE VIRAL GENE …
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Characterization of the Interactions Between Kaposi’s Sarcoma-Associated Herpesvirus ORF57 and Its RNA Partners
… has evolved mechanisms to modulate both host and viral gene expression. The essential and multifunctional KSHV ORF57 protein has been reported to enhance viral gene expression at multiple levels including transcription, splicing, mRNA export, RNA stability, and translation. At least in some cases, …
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Influenza a virus gene expression heterogeneity regulates viral superinfection potential and host innate antiviral response
… in the U.S. alone. Its genome consists of eight gene segments each encoding one or more viral proteins. The expression of all eight genes is required to initiate productive infection. Interestingly, under the single particle infection condition, most IAV particles are semi-infectious particles …
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Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
… of host-virus interactions. While miRNAs of viral and cellular origin have been demonstrated to modulate viral gene expression and host immune responses, reports detailing these activities in the context of mammalian retroviruses have been controversial. Using modern, high-throughput small …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… question is how B cell signaling regulates viral gene expression during establishment and reactivation from latency. The MHV68 M2 gene, a proposed functional analog of the EBV LMP2A and KSHV K1 genes, encodes a latency-associated protein that controls establishment and reactivation from …
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Temporal Regulation of LMP1 and Apoptosis Resistance After Primary EBV Infection
… in the settings of immune suppression, genetic, and/or environmental factors. While a highly successful pathogen based on prevalence, the ability of the virus to immortalize human B cells (a stage of infection thought to be critical for the establishment of latency) is quite poor. We …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
… alterations in 3D genome organization and epigenetic landscape following SARS-CoV-2 infection that are distinct from and more severe than changes caused by other viral infections or immune stimulants. While these changes at the chromatin level are important for understanding the immune …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… lytic or latent infection. Latency is a state of viral quiescence where the virus can persist indefinitely yet remain poised to reactivate. Latency is unique to herpesviruses and key to HSV's success, but the molecular mechanisms that govern this state are unclear. A virus-encoded E3-ubiquitin …
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THE ADENOVIRUS E1B-55K AND E4ORF6 PROTEINS LIMIT PKR-MEDIATED EIF2A PHOSPHORYLATION DURING THE LATE PHASE OF INFECTION
… and E4orf6 proteins promote efficient late viral gene expression. The results presented in this dissertation reveal that the E1B-55K and E4orf6 proteins facilitate late viral protein synthesis by limiting phosphorylation of eIF2α by the dsRNA-dependent protein kinase R (PKR) during the late …
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Regulation of Human T-cell Leukemia Virus Type 1 Infection and Replication
… to regulate their cellular tropism and gene expression. It is generally accepted that productive infections proceed via interactions between viral envelope molecules and specific receptors on the host cell surface. Currently, there is no known receptor for HTLV-1, though a number of …
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Using the single-cycle flavivirus particle replivax to study flavivirus replication and immune response
… which contains a deletion in the capsid (C) gene of West Nile virus (WNV) that prevents the formation of infectious particles, unless the C gene is trans-complemented by a WNV C-expressing cell line. RepliVAX immunization results in a single round of infection, where the replication of genome …
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Immunotherapy for murine glioma
Oncolytic viral immunotherapy is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We …
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Upregulation of Reactive Oxygen Species During The Retrovirus Life Cycle and Their Roles In A Mutant of Moloney Murine Leukemia Virus, Ts1-Mediated Neurodegeneration
<p>Viral invasion of the central nervous system (CNS) and development of neurological symptoms is a characteristic of many retroviruses. The mechanism by which retrovirus infection causes neurological dysfunction has yet to be fully elucidated. Given the complexity of the retrovirus-mediated …
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The Cellular Mirna, Mir-190, is Upregulated in Type I Ebv Latency by Ebers and Modulates Cellular Mrnas involved in Cell Survival and Viral Reactivation
… of post-transcriptionally regulating mRNA expression. A microarray comparison of EBV type I latency and type III latency infected cells yielded evidence of differential cellular microRNA expression. I hypothesized that one of these differentially upregulated type I latency miRNAs, miR-190, …
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The Role of Viral Protein pUL21a in Human Cytomegalovirus Infection
… of many of the roughly 200 putative HCMV genes are still unknown. One of these genes, UL21a, was shown to be critical for efficient viral replication in two large-scale mutagenesis studies. UL21a encodes for a putative protein that is 123 amino acids and has no homology to any known …
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Characterization of single-cycle flavivirus particles for use as a vaccine to prevent West Nile disease and to examine immune responses to flavivirus infection
… (WNV) is responsible for the largest outbreak of viral encephalitis in the history of North America, yet there are no vaccines available to prevent this disease. To address these needs we have developed RepliVAX WN, a single-cycle flavivirus (SCFV)-based vaccine to prevent West Nile disease. …
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Human Cytomegalovirus and the Neutrophil
… infect virtually any cell type, with detectable gene expression and release of new virions, but not the neutrophil. This cell is the first immune cell to engage most pathogens, engulfing and killing them before undergoing apoptosis and clearance by macrophages. However certain viruses and …
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