Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Viral evolution"”.
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Protein Folding, Host Cell Proteostasis, and Viral Evolution
… associated with developing effective antiviral strategies is the exceptionally high mutation rate of RNA viruses, which endows them with a remarkable capacity to adapt to selection pressures such as antibodies or antiviral drugs. Hence, it is critical to understand the molecular-level …
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Graph-Based Computational Approaches for Modeling Viral Evolution
Modeling viral evolution is essential for understanding how pathogens adapt, spread, and generate new variants of concern. Yet, it remains challenging due to high mutation rates, minimal sequence divergence, and the scale of modern genomic data. Most phylogenetic trees enforce a strictly …
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HIV-1 strain-specific neutralizing antibody responses and the dynamics of viral evolution
… development of breadth is influenced by the co-evolution of the transmitted/founder (t/f) virus and earlier strain-specific neutralizing antibody (ssnAb) responses. Here we characterized the viral evolution, ssnAb and bnAbs responses in CAP292, an HIV-1 infected woman who developed bnAb …
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Utilising machine learning techniques on simulated viral evolution datasets to improve viral recombinant identification
… machine learning applications for enhancing viral recombination detection. Using SANTA-SIM-generated viral evolution data, multiple computational approaches were developed and evaluated against existing methods in the Recombination Detection Program (RDP5). The study trained and tested …
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Single-Molecule Protein Sequencing (I) and Genetically Dominant mRNA Therapies to Combat Viral Evolution (II)
Proteins serve critical structural and dynamic functional roles at the cellular level of all living organisms. Understanding protein contribution to biological function is critical and rests on having appropriate technologies for quantification and identification. The central dogma of molecular …
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A study of HIV-1 dual infection in a cohort of subtype C infected sex workers : viral evolution and its association with disease progression
Includes bibliographical references (leaves 191-221).
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Integrative approaches to decipher influenza evolution, antibody responses, and AI-driven specificity prediction
The ongoing threat of viral pathogens, such as SARS-CoV-2 and influenza Viruses, highlights the urgent need to understand immune responses and viral evolution to guide therapeutic and vaccine development. This dissertation integrates high-throughput experimental techniques and artificial …
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Learning from pre-pandemic data to design and test future-proof therapeutics
… preparedness relies on predicting immune-evasive viral mutations to enable early detection of variants of concern and design vaccines and therapeutics that are resilient to future viral evolution. However, current strategies for viral evolution prediction are not available early in a pandemic and …
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High-throughput profiling of viral class I fusion proteins via mammalian antigen display
Viral infections, particularly epidemics and pandemics, pose a significant threat to global health, causing substantial morbidity, mortality, and socioeconomic disruption. Moreover, viruses can cause chronic disease long after initial infection. While modern technologies enable early outbreak …
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High-throughput profiling of viral class I fusion proteins via mammalian antigen display
Viral infections, particularly epidemics and pandemics, pose a significant threat to global health, causing substantial morbidity, mortality, and socioeconomic disruption. Moreover, viruses can cause chronic disease long after initial infection. While modern technologies enable early outbreak …
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Toward the Rational Design of Better Antivirals: The Development of cGAMP as an HIV-1 Anti-Retroviral and the Genetic Surveillance of WNV Evolution
… in humans. Understanding the consequences of viral evolution can give insights to mechanisms of viral pathogenesis as well as the development of novel therapeutics. Here I studied two clinically important viruses: Human Immunodeficiency Virus (HIV) and West Nile Virus (WNV). HIV-1 has evolved …
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Chaperoning viral protein evolution
Preventing viral pandemics and developing effective antiviral therapeutics demands understanding the molecular mechanisms that both potentiate and constrain viral evolution. The rapid evolution of viruses is mediated in part by their high mutation rates, enabling resistance to antiviral drugs, …
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Structural and functional advances in the evolutionary studies of cells and viruses
Phylogenomics aims to describe evolutionary relatedness between organisms by analyzing genomic data. The common practice is to produce phylogenomic trees from molecular information in the sequence, order and content of genes in genomes. These phylogenies describe the evolution of life and have …
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Learning from pre-pandemic data to forecast viral antibody escape
… pandemic preparedness relies on anticipating viral mutations that are able to evade host immune responses in order to facilitate vaccine and therapeutic design. However, current strategies for viral evolution prediction are not available early in a pandemic – experimental approaches require …
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Evolution of viral populations in individuals infected with single and multiple HIV subtypes : a study of HIV-1 dual infection in a high risk cohort of female bar workers from Tanzania
… pressure exerted by the host. The role of high viral diversity in disease progression in context of infection with more than one subtype (dual infection) is not elucidated. Delineating of the evolving viral diversity in dual infection will contribute to our understMding of HIV pathogenesis and …
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A study of the ecology & diversity of bacteriophages
… our understanding of the mechanisms involved in viral evolution within a single soil sample and supported the findings of previous studies.
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High Throughput Sequencing of SARS-CoV-2
… and 25563. Based on our regression analysis, the viral rate of mutation in patients decreases after about 21 days. This suggests that prolonged infection does not result in a steady rate of viral evolution within individuals.
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On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… of viruses across the world. The addressable viral spectrum ranges from emerging viruses such as Nipah virus (NiV), which appear sporadically as local zoonotic outbreaks with high mortality, to continually-evolving endemic viruses such as influenza A (flu). Meanwhile, SARS-CoV-2 is currently …
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Molecular epidemiology of West Nile virus in North America
… of 1999 led to the largest epidemic of arboviral encephalitis ever recorded in the Western Hemisphere during 2002. Over the course of six years, the distribution of WNV has expanded to include each of the contiguous U.S. states and seven Canadian provinces, as well as Mexico, several …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… responses play a pivotal role in controlling viral replication during HCV infection. HCV evades the immune system by rapid viral evolution affording escape from immune selection pressure including at MHC-I restricted epitopes. However, some CTL epitopes remain conserved well past the time of …
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