Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Viral entry"”.
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Characterization of Host Factors Affecting Viral Entry
The file named "RINKENBERGER-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.
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A study of viral entry proteins and receptors using deep mutagenesis
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… To assess the virologic events involving viral entry and spread, macaques were orally inoculated with SIV and necropsied at early times post-infection (days 1 - 14). These studies were the first to identify the preferential entry sites for the virus as the oral and esophageal mucosa, as …
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Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
… successfully recovered in 293 cells. The herpesviral glycoproteins are structural components of the KSHV particle and are thought to facilitate virus entry, egress and virus-induced cell fusion. Investigations, described herein, have focused on the genetic manipulation of the KSHV-BAC36 in order …
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The Rational Design, Synthesis, And Biological Evaluation Of Small Molecule Cd4 Mimetic Families For Hiv-1 Viral Entry Inhibition
… (P01 AI 150471), has been to target the HIV-1 viral envelope as a means to prevent HIV-1 viral entry and subsequent infection. The small molecules developed in the Smith Laboratory, based on initial findings by Debnath and coworkers, act as mimics of the natural immune system receptor CD4, …
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THE ROLE OF CORONAVIRUS - HOST CELL MEMBRANE INTERACTIONS DURING VIRAL ENTRY AS MEDIATED BY CONSERVED REGIONS OF THE FUSION PEPTIDE
… need for a deeper understanding of coronavirus entry mechanisms to better predict and prevent future variants and pandemics. Central to viral entry is the binding and fusion of the virus with the host cell membrane, a process orchestrated by the Spike (S) protein. Within the S, the fusion …
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The Design And Synthesis Of Inhibitors Of Hiv-1 Viral Entry And Photoaffinity Labeled Probes For Structural Elucidation Of The Hiv-1 Env
… HIV-1 can be effectively treated with antiretroviral therapy (ART), the efficacy of ART is challenged by its cost, required access to regular care, and the onset of viral resistance. Methods to both prevent and cure HIV-1 infection are thus desperately needed. Three such strategies are described …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… that was used to screen for novel inhibitors of viral infection. Benztropine (an inhibitor targeting B0AT1 that complexes with ACE2) and DX600 (a peptide antagonist of ACE2), were shown to exhibit antiviral properties for the first time. Additionally, the tissue expression and distribution of a …
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Solid-state NMR investigation of viral fusion glycoprotein 41 (gp41)
… integral part of numerous cellular processes and viral entry. The HIV envelope glycoprotein mediates viral entry into target cells by fusing the viral envelope with the cell membrane. This process requires large-scale and multi-step conformational changes of the viral fusion protein gp41. Our …
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Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
… viruses (SIV) exhibit high plasma viral loads without widespread CD4+ T cell loss. By contrast, non-natural host rhesus macaques experimentally infected with related SIV exhibit high viral loads but display subsequent CD4+ T cell loss and progression to AIDS, analogous to the …
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Mechanisms of CCR5 Agonist/Antagonist Inhibition of HIV-1 Entry and In Vitro Selection of Virus Resistant to Maraviroc
Entry inhibitors represent a new class of antiretrovirals for the treatment of HIV-1 infection. These inhibitors target interactions of the viral envelope glycoprotein with host cell receptors as well as fusion of the viral and host cell membranes. Extensive development of inhibitors that target …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… to long term morbidity and possible mortality. Viral entry into cells requires the co-ordinated action of at least four HSV-1 envelope glycoproteins: gB, gD and the heterodimer gHgL. Dendritic cells (DC) are the most potent antigen presenting cells and are likely to encounter the virus early …
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High-throughput profiling of viral class I fusion proteins via mammalian antigen display
Viral infections, particularly epidemics and pandemics, pose a significant threat to global health, causing substantial morbidity, mortality, and socioeconomic disruption. Moreover, viruses can cause chronic disease long after initial infection. While modern technologies enable early outbreak …
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High-throughput profiling of viral class I fusion proteins via mammalian antigen display
Viral infections, particularly epidemics and pandemics, pose a significant threat to global health, causing substantial morbidity, mortality, and socioeconomic disruption. Moreover, viruses can cause chronic disease long after initial infection. While modern technologies enable early outbreak …
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
… the brain. Autopsy studies later suggested that viral entry is also mediated by failure of the blood brain barrier due to inflammation. Missing from these studies was an assessment of the susceptibility of the PNS to infection and to its role in CNS invasion. In this dissertation I show that both …
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Regulation of Human T-cell Leukemia Virus Type 1 Infection and Replication
… infections proceed via interactions between viral envelope molecules and specific receptors on the host cell surface. Currently, there is no known receptor for HTLV-1, though a number of factors that enhance entry have been identified. In an effort to identify a cellular receptor or …
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PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
Herpes simplex virus entry into cells is a multistep process that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in the maintenance of cell homeostasis. A battery of assays were used to demonstrate that proteasome …
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… The purpose of this study is to understand the viral entry process of KSHV in tonsil-derived B lymphocytes. This study will particularly explore the role of KSHV glycoprotein gH and cell surface receptor DC-SIGN.</p> <p>The first aim of this project will investigate whether the cell surface …
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ENDOGENOUS ANTIVIRAL PROPERTIES OF RED BLOOD CELL-DERIVED EXTRACELLULAR VESICLES AND THEIR AUGMENTATION OF ANTIVIRAL OLIGONUCLEOTIDE THERAPY
… the urgent need for effective and accessible antiviral therapies. We explored the intrinsic antiviral activity of red blood cell-derived extracellular vesicles (RBCEVs) against SARS-CoV-2 and their use as delivery vehicles for antisense oligonucleotides (ASOs). RBCEVs inhibited both pseudotyped …
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Entry of feline infectious peritonitis virus in blood monocytes
… pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the development of new therapeutic agents. However, little is known about the entry of FIPV. It is even questioned if the virus enters cells via direct fusion with the plasma membrane or after …
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