Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Viral Tropism"”.
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Molecular basis oh herpes simplex virus entry into the cell and retargeting of the viral tropism for the design of oncolytic herpesviruses
… of glycoproteins that execute the fusion of the viral envelope with the plasma membrane. In this thesis, I described two distinct projects: I. The retargeting of viral tropism for the design of oncolytic Herpesviruses: • capable of infecting cells through the human epitelial growth factor …
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Cell surface interactions of Coxsackie A9 virus
… showed evidence that this is related to viral tropism and infectiousness of the virus. CAV9 has also been reported to interact with the heparan sulphate/heparin class of proteoglycans (HSPG). This thesis describes work designed to improve our understanding of the involvement of a) the RGD …
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Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection
… <li> <p>Examining Host-Specific Differences and Viral Tropism in KSHV Infection of Tonsil-Derived B Lymphocytes</p> </li> <li> <p>Validating the Proteomic Composition of KSHV Virions</p> </li> <li> <p>Establishing the Contribution of KSHV-ORF11 Tegument Protein in de novo</p> <p>Infection of B …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
Activation of host cell responses during viral infection can be a critical factor in determining of viral tropism, dissemination, and pathogenesis. The paramyxovirus simian virus 5 (SV5) is able to establish highly productive, persistent infections of cultured epithelial cells with minimal …
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Deciphering Features of Protective or Maladaptive Cellular Immunity in the Airways Following Primary and Repeated Pathogen Exposure
… allergens, toxins, and microbes). Infection with viral, microbial, and eukaryotic pathogens can disrupt airway homeostasis, leading to local and systemic inflammation, which can either contribute to the clearance or persistence of the pathogen. Prior antigenic exposure - prophylactically or from a …
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PIECING TOGETHER THE PUZZLE OF TREATING HEMOPHILIA A UTILIZING AAV BASED GENE THERAPY
… of AAV is time and labor intensive. AAV tropism has not been documented to all tissue types and some tissues like the lungs and heart are underserved in that respect. Contamination of viral preparations is also an issue as the production of AAV creates many virions that do not contain the …
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Factors That Influence Murine Norovirus Stability and Tropism
… that influence murine norovirus stability and tropism through two independent projects. Murine norovirus (MNV) is a model system used to study human noroviruses due to its robust replication in cell culture and mouse model. I first investigated the interactions between MNV and bacteria in vitro …