Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Viral Systems"”.
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The Tradeoffs for a Viral Mutant with Enhanced Replication Speed
… speed. We found that a single mutation in a viral capsid protein, VP1-F106L, was sufficient for the fast-replication phenotype. Characterization of this mutant revealed quicker genome release during entry compared to wild-type virus, highlighting a previously unappreciated infection barrier. …
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Synthesis and chemical modification of degradable polymers to enhance gene delivery
… the state-of-the-art, commercially available non-viral systems. The main objective of this thesis is to synthesize new poly([beta]-amino ester)s and modify existing ones to further improve their gene delivery properties for clinical applications. This has been accomplished by developing both side- …
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Computational investigation of membrane-associated phenomena and viral proteins
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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COMPUTATIONAL MULTISCALE INVESTIGATIONS OF BIOLOGICAL MOLECULES
… the intricate workings of biological systems at the molecular level is crucial for unraveling the complex mechanisms that underlie Life itself. Proteins and RNA, two essential components of cellular structure and processes, exhibit remarkable structural and functional diversity. …