Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Viral Persistence"”.
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Evaluation of bacteriophage and viral persistence during alkaline stabilization in sludge and biosolids intended for land application
… stabilization was designed to evaluate pathogen persistence. The survivability of poliovirus type 1, fecal coliforms, Salmonella, adenovirus type 5, rotavirus Wa, and the male-specific bacteriophage MS-2 was evaluated under lime stabilization conditions in various matrices. Salmonella and fecal …
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Identification of reassortant influenza viruses at scale : algorithm and applications
… finding reassortant viruses in tens of thousands viral isolates. Together with colleagues, we then use the algorithm to test whether reassortment events are over-represented in host switching events and whether reassortment is an alternative 'transmission strategy' for viral persistence.
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Human Papillomavirus Infections and Human Papillomavirus Associated Diseases in Nigeria: Distribution, Determinants and Control
… cause of cervical cancer. Behavioural, viral and host factors modulate the risk of HPV persistence. In this thesis, I explore the role of the vaginal microbiota, a host factor and the presence of multiple HPV infections, a viral factor in HPV persistence. Considering the limited data on …
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T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling.
… by PD-1 and PDL-1 is associated with persistent viral infection. The role, if any, that PD-1/PDL-1 has in HCV infection is unknown. In this study we report that PD-1 is upregulated in T-cells from persons with chronic HCV infection when compared to healthy donors. In addition, PD-1 and PDL-1 are …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… host cytokine signaling activities to facilitate viral persistence and escape host immune surveillance.</p> <p>Despite three decades of research, there are still many questions in this field awaiting further investigation. This dissertation will investigate host cytokines as factors influencing …
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Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
The reasons for the viral persistence of hepatitis B virus (HBV) infection are unknown, but are probably related to host immune factors. Cytokines play significant roles in inflammatory and immune defense. This study was undertaken to investigate the association between HBV infection and …
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Constraints on the CD8 T cell response in chronic HBV infection
… provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total circulating and intrahepatic CD8 T cells in CHB patients and healthy donors. We demonstrated that CD8 T cells from CHB patients, regardless of their antigen …
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
… NA had little effect on HBV cccDNA level and persistence of mRNA in PBMC. The study on HBV genetic features in CHB carriers with acute-on-chronic liver failure (ACLF) revealed the frequent immune escape mutations with clusters of surface gene variants possibly associated with development of …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
… the late genes which encode highly immunogenic viral structural proteins are only expressed in the suprabasal layers. HPV-16 infections are normally cleared within 18-24 months, but HPV-16 can establish persistent infections that progress to cancer. Such HPV-infected cancer cells express early …
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Bioinformatics e Biostatistics applied to research in pediatric genetic disease. Clinical evidence in IFNλ4 polymorphisms associated with HCV infection in patients with beta thalassemia and WGCNA analysis weighted for IFNλ4 genotype rs12979860 to detect RPL9P18 as hub in HCV infected cell.
… the positive predictive power was stronger for viral persistence than spontaneous clearance indeed TT allele was more predictive than CC. Another polymorphism rs4803221 was analyzed because had independent effects respect to rs12979860. The haplotype tagged by SNP rs12979860 and rs4803221 …
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Subacute measles encephalitis: The neurological sequelae of the measles outbreak in South Africa
… Early in the disease course there may be direct viral involvement as a primary measles encephalitis or indirectly as an inflammatory immune mediated demyelinating meningoencephalitis. Latent infections are rare and may manifest in two ways: years later as subacute sclerosing panencephalitis …
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Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
People with HIV (PWH) who are on antiretroviral therapy (ART) continue to suffer from chronic inflammation, dental diseases, and increased rates of depression, despite substantial viral suppression. The endoplasmic reticulum (ER) stress sensor, protein kinase R–like endoplasmic reticulum kinase …
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HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
… Spastic Paraparesis (HAM/TSP). The viral protein HBZ is consistently expressed in infected individuals and plays a crucial role in viral persistence and disease progression. This dissertation investigates the role of the cellular protein Myoferlin (MyoF) as a downstream effector of …
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Characterizing the cellular latent reservoir of HIV-1 and the effect of immune activation on characteristics of the reservoir
Since the advent of antiretroviral therapy (ART) and the resultant suppression of viraemia in the majority of people living with HIV-1 (PLWH) on ART, HIV-1 infection has become manageable and PLWH have similar life expectancies as uninfected persons. However, ART is not curative, is needed …
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A study of immune responses during antiviral treatment for hepatitis C virus infection
… of HCV specific T cell responses caused by viral escape and T cell exhaustion considered to be mediated by constant antigen stimulation. Hepatitis C virus has developed strategies to escape innate immune responses leading to chronic infection in the face of ongoing innate immune activity. …
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Identification of Viral Determinants of Murine Norovirus Pathogenesis
… importance as human pathogens, knowledge of the viral life cycle and host pathogenesis is limited due to the lack of practical models to study. In contrast, murine norovirus: MNV) has been a critical surrogate for the study of human noroviruses as it is the only member of this genus that …