Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"Viral Pathogenesis"”.
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Intersecting Threats: Exploring Obesity's Impact on Viral Pathogenesis and Transmission
… in high-income countries (HICs). Mosquito-borne viral diseases like dengue, chikungunya, and Zika pose a significant threat to LMICs and cause huge health and economic losses. Obesity was shown to worsen alphavirus pathogenesis, but interestingly, it also reduced their transmission by mosquitoes. …
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Interactions Among Murine Cytomegalovirus US22 Family Gene Products That Influence Viral Pathogenesis
… are the key target cell type involved in pathogenesis, which is most effectively studied using the murine model of CMV infection. Previously three murine CMV (MCMV) genes (M139, M140, and M141) were identified to regulate viral expression in cultured macrophages and in mice. These genes …
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Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… for MCV infections. The knowledge of MCV pathogenesis is rudimentary because there is no proper system of propagation nor an animal model to study MCV during infection. The proinflammatory cytokine Tumor Necrosis Factor (TNF) is highly expressed in MCV lesions and surrounding tissues. …
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Characterization of the vaccinia virus ankyrin repeat protein K1 on NF-κB inhibition and its contributions to viral pathogenesis
All viruses strategically alter the anti-viral immune response to their benefit. The goal of this thesis was to examine how the vaccinia virus (VACV) K1 protein, which is encoded by the K1L gene, modulates the immune response in vitro and in vivo. In vitro, the K1 protein has multiple …
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The impact of HIV-1 subtype C Envelope N-glycosylation on DC-SIGN meditated modulation of DC function to facilitate transmission or enhance viral pathogenesis
… hypothesized that Env N-glycosylation may affect viral pathogenesis by influencing Env structure and function. Furthermore, we also postulated that differences in Env glycosylation could affect interactions between Env and DC-SIGN of dendritic cells (DCs), activating alternative signalling …
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West Nile virus versus the host cell: Identification of host factors that modulate infection
… and (ii) those that reduce or prevent viral replication and transmission. Each of these types of interactions is critical and both must be investigated to fully understand viral pathogenesis. Cells encode a variety of molecules which are critical for recognizing viral infections. One …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… despite its critical functions in viral assembly and release, as well as its role as a major contributor to viral pathogenesis. Its contribution to viral pathogenesis has been strongly linked to a C-terminal PDZ-binding motif (PBM) that interacts with host post synaptic density …
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The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver
… effective therapies that target the persisting viral molecules are needed in order to clear infection. My research aims to understand the role of hepatitis B virus (HBV) in inducing HCC and identify novel host molecules that are targeted by HBV. Understanding how HBV modifies and manipulates …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… for a detailed understanding of SARS-CoV-2 pathogenesis. The angiotensin-converting enzyme (ACE2) receptor of SARS-CoV-2 is displayed on many human cells, including the lungs and other organs. However, despite considerable knowledge explaining the SARS-CoV-2 infection mechanism, …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. NS1 forms a homodimer necessary for viral replication and it is also secreted as a hexamer and is involved in immune system evasion and pathogenesis. Like other flaviviruses, the …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. NS1 forms a homodimer necessary for viral replication and it is also secreted as a hexamer and is involved in immune system evasion and pathogenesis. Like other flaviviruses, the …
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Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin
… by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and a2-3 linked to the penultimate …
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… novel large animal model for EV71 to investigate viral pathogenesis, immunity, and to evaluate vaccine and antiviral drugs. Using the well-established Gn pig model for HRV, the adjuvant and therapeutic effects of prebiotics rice bran (RB) and probiotics were evaluated. RB alone or RB plus …
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The role of -2/-1 ribosome frameshifting mechanism in PRRS virus replication
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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Toward the Rational Design of Better Antivirals: The Development of cGAMP as an HIV-1 Anti-Retroviral and the Genetic Surveillance of WNV Evolution
… in humans. Understanding the consequences of viral evolution can give insights to mechanisms of viral pathogenesis as well as the development of novel therapeutics. Here I studied two clinically important viruses: Human Immunodeficiency Virus (HIV) and West Nile Virus (WNV). HIV-1 has evolved …
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Host response to Rift Valley fever virus infection
… to infection with RVFV and correlation with viral pathogenesis. My goal was to be able to discern the host response to infection and to correlate the response with development of RVFV-induced pathogenesis. My efforts have centered on understanding how host immune-modulatory cells respond to …
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Dissociating Siv Env and Cd4: Consequenes for Virus and Host
… primate lentiviruses and likely contributes to viral pathogenesis by targeting cells that are critical for the adaptive anti-viral immune responses. Although CD4-independent variants of HIV and SIV have been described that can utilize coreceptors CCR5 or CXCR4 in the absence of CD4, these …
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LncRNA Nostrill Facilitates Neuronal Antiviral Responses by Promoting NFkB-Mediated Irf7 Transcription
Differences in antiviral and inflammatory gene expression influence viral clearance in the central nervous system. Persistent antiviral and inflammatory gene expression are associated with neurodegeneration and the development of neurodiseases. Long non-coding RNAs (LncRNAs) are key cell-specific …
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The interactions of the cucumber mosaic virus 2b protein with the viral 1a and host Argonaute 1 proteins
… plant defences and an important determinant of viral pathogenesis. The effect of the 2b protein on symptom induction is due in large part to its physical interaction with the host RNA silencing factor Argonaute 1 (AGO1). The consequent inhibition of AGO1 activity induces developmental symptoms …
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On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… of viruses across the world. The addressable viral spectrum ranges from emerging viruses such as Nipah virus (NiV), which appear sporadically as local zoonotic outbreaks with high mortality, to continually-evolving endemic viruses such as influenza A (flu). Meanwhile, SARS-CoV-2 is currently …
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