Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Viral Mutation"”.
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Studies On The Determinants Of HIV Mutagenesis And Strategies For Its Enhancement
… evolving entities on earth, due in part to a mutation rate that is at least 10,000-fold higher than that of eukaryotic genomic DNA. The adaptability of HIV-1 prevents clearance of the virus by the immune system, promotes drug resistance, and has impeded development of effective vaccines. The …
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Modeling the Effects of Drugs of Abuse on HIV Infections with Two Viral Species
… abusers infected with HIV suffer from a higher viral load and rapid pathogenesis. Replication of HIV may result in a large number of mutant viruses that can escape recognition of the hosts immune response. Experimental results have shown that the presence of morphine can decrease the viral …
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Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse
… have also been associated with de creasing the viral mutation rate. The rapid replication of HIV may result in increased production of mutant viruses that can escape detection by the host’s immune system. This shows that the use of drugs of abuse can make it harder to effectively manage HIV …
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CRISPR immune diversity in simulated and natural microbial populations
… one of the ways in which microbes defend against viral infection, and it also holds a record of acquired immunity, allowing us to read a history of microbe-viral interactions. In this work, we examine the emergence, impact, and applications of diverse CRISPR immune alleles in microbial …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… responses play a pivotal role in controlling viral replication during HCV infection. HCV evades the immune system by rapid viral evolution affording escape from immune selection pressure including at MHC-I restricted epitopes. However, some CTL epitopes remain conserved well past the time of …