Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2980 for “"Viral"”.
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The Viral Fingerprint: A Content Analysis of Popular Viral Advertisements
… the Advertising Age weekly chart of the top ten viral videos of the week; the videos appeared on the chart from March 23rd 2009 to March 9th 2011. The videos were analyzed along four areas of observation including the advertiser characteristics, the formatting characteristics of the video, the …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… cancers. ORF59, a DNA processivity factor of the viral DNA polymerase, is essential for lytic reactivation and is highly expressed during de novo primary infection. To better understand the role of ORF59, we performed an ORF59-immunoprecipitation from KSHV infected cells and identified ORF59 …
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Chaperoning viral protein evolution
Preventing viral pandemics and developing effective antiviral therapeutics demands understanding the molecular mechanisms that both potentiate and constrain viral evolution. The rapid evolution of viruses is mediated in part by their high mutation rates, enabling resistance to antiviral drugs, …
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VIRAL SAFETY EVALUATION OF BIOTECHNOLOGY PRODUCTS: DEVELOPMENT AND OPTIMIZATIONOF RELIABLE VIRAL CLEARANCE STRATEGIES
… to the study, optimization, and validation of viral clearance strategies within downstream processing for monoclonal antibody (mAb) production, with the overarching goal of establishing procedures that are effective, reproducible, and fully transferable to the biopharmaceutical industry. During …
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Utilising machine learning techniques on simulated viral evolution datasets to improve viral recombinant identification
… machine learning applications for enhancing viral recombination detection. Using SANTA-SIM-generated viral evolution data, multiple computational approaches were developed and evaluated against existing methods in the Recombination Detection Program (RDP5). The study trained and tested …
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Countermeasures Against Viral Hemorrhagic Fevers
Viral hemorrhagic fevers (VHFs) are a group of viruses from four different virus families that are characterized by coagulation abnormalities with often fatal outcomes. VHFs can cause both internal and external bleeding. The virus families include: Filoviridae, Arenaviridae, Bunyaviridae, and …
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Lifecycle of viral YouTube videos
… that has been coined to describe such videos is "viral videos." This comes from the scientific definition of viral, which involves the contagious nature of the spread of a virus. Virality on the Internet is not a new concept. Back when email was the hottest new technology, chain e-mails spreading …
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Autophagy Delivers Viral Antigens for MHC Class II Presentation and is Regulated by Viral Infection
… II antigen presentation has been described for viral and model antigens and might represent an important mechanism to initiate CD4<sup>+</sup> T cell responses to intracellular pathogens. We studied this unusual MHC class II presentation pathway using the Epstein- Barr virus nuclear antigen 1 …
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Multiscale Modelling of Hepatic Viral Infection
The multiscale modelling of hepatic viral infection was introduced in this work and various approaches were carried out to contribute effectively to the control and eradication of viral hepatitis in sub-saharan Africa. A nested multiscale model was developed by applying the Replication-Transmission …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… of primary infection. The clinical outcomes in viral hepatitis can range from complete pathogen clearance and recovery of liver function to failure to contain the infection and loss of liver function. Because hepatotropic viruses are one of the major etiologic causes of morbidity and mortality …
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Immune reactions in acute viral hepatitis
viii, 122 leaves
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Systems Engineering for Viral Vector Manufacturing
… of rAAVs. However, current state-of-the-art viral vector manufacturing methods still fall short of meeting current and future demands. Transient transfection via triple transfection of plasmids is the most common manufacturing platform for the clinical stage due to its flexibility in changing …
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Immunoepidemiological Modeling of Dengue Viral Infection
Dengue viral infection is a mosquito-borne disease with four distinct strains, where the interactions between these strains have implications on the severity of the disease outcomes. The two competing hypotheses for the increased severity during secondary infections are antibody dependent …
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Mathematical Modeling of Dengue Viral Infection
In recent years, dengue viral infection has become one of the most widely-spread mosquito-borne diseases in the world, with an estimated 50-100 million cases annually, resulting in 500,000 hospitalizations. Due to the nature of the immune response to each of the four serotypes of dengue virus, …
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Investigating viral subversion of intercellular communication
… including acute respiratory disease and viral myocarditis. Gap junctions, which are formed by connexin proteins, directly couple the cytoplasms of apposed cells enabling immunological, metabolic, and electrical intercellular communication. The gap junction protein connexin43 (Cx43; gene …
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Direct generation of region-specific induced neural Precursors from adult human fibroblasts using non-viral and viral methods
… of induced neural precursors (iNPs) using non-viral and viral methods to determine whether reprogrammed iNPs express the same sequential gene profile as that observed in human neural development. The expression of genes controlling neural induction and forebrain specification was examined by …
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Characterization of Host Factors Affecting Viral Entry
The file named "RINKENBERGER-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.
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