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Showing 1 to 20 of 34 for “"Vincristine"”.
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Vincristine Metabolism and the Role of CYP3A5
Vincristine is metabolized by the cytochrome P450 3A subfamily of enzymes possibly including CYP3A5, a genetically polymorphic enzyme. The contribution of CYP3A5 to the metabolism of vincristine was quantified by various in vitro models: cDNA-expressed enzymes, human liver microsomes, and human …
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A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba
Vincristine and vinblastine, two closely related alkaloids are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has …
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
… ten continuous xenografts to dexamethasone and vincristine, but not methotrexate, significantly correlated with patient outcome (p<0.05). Xenograft sub-lines resistant to vincristine, dexamethasone, methotrexate and cytosine arabinoside were also selected by in vivo drug treatments, although …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΗΜΙΟΛΟΓΙΑΣ ΚΑΙ ΤΗΣ ΑΝΤΙΜΕΤΩΠΙΣΗΣ ΤΟΥ ΑΦΡΟΔΙΣΙΟΥ ΜΕΤΑΔΟΤΙΚΟΥ ΝΕΟΠΛΑΣΜΑΤΟΣ ΣΤΟ ΣΚΥΛΟ
… TREATMENT CONSISTED OF THE ADMINISTRATION OF VINCRISTINE, CYCLOPHOSPHAMIDE AND METHOTREXATE, AND IN 140 DOGS OF VINCRISTINE ONLY. IN 18 CASES TREATMENT CONSISTED OF REMOVAL OF NEOPLASTIC TISSUES BY MEANS OF SURGERY. ALL THE ANIMALS OF THE FIRST GROUP WERE CURED; THERE WERE NO RELAPSES OF THE …
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Structural and Functional Analysis of Substrate Recognition and Inhibition of the Multidrug Transporters MRP1 and MRP2
… of MRP1 bound to GSH and the chemotherapeutic vincristine. The cysteine thiol of GSH, which is bound in the relatively polar P-pocket of the MRP1 substrate-binding site, forms a key intermolecular interaction with vincristine, which is bound in the relatively hydrophobic H-pocket. I also …
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Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
… restricts the transepithelial transport of vincristine in the apical-to-basolateral direction whilst facilitating its transport in the reverse direction and accumulates less vincristine than non-exposed cells. There is no apparent evidence of the co-existence of the multidrug resistance …
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A Multielectrode Microcompartment Platform for Signal Transduction in the Nervous System
… effects of the chemotherapeutic drug vincristine on DRGs. Conventional electrophysiological recordings (via a patch micropipette) are made routinely to record action potentials and ion channel activity in neurons. Moreover, Campenot chambers (traditional compartmented culture systems) …
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Bioreactor design for scaleup of Catharanthus roseus hairy root cultures for production of indole alkaloids
… of the important anticancer indole alkaloids, vincristine and vinblastine. Hairy root cultures are an attractive alternative for the production of plant derived secondary metabolites. C. roseus hairy root cultures were established in our laboratory by A. rhizogenes mediated transformation of C. …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
… by 50%. Subsequently, we combined GLL-618 with vincristine, a prevalently used chemotherapy drug for the treatment of high-risk NB. GLL-618 could synergistically increase the anti-tumor effect of vincristine, which was evidenced by an overall 70% tumor weight reduction at the treatment endpoint …
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Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /
… indole alkaloids (MIA) vinblastine and vincristine, which are key pharmaceutical compounds that are used to combat a number of different cancers. Therefore, procurement of the antineoplastic agents is difficult but essential procedure. Alternatively, CatharanthllS tissue cultures have …
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Synthesis and biological activity of ajoenes with increased aqueous solubility
… of two chemotherapeutic drugs Doxorubicin and Vincristine via chemosensitization. This effect was attributed to the presence of at least one p-methoxybenzyl substituent in the structure.
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Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells
… concentrations on apoptosis induced by vincristine, a commonly used cancer therapeutic agents, in both CNE2 and HK1 cells. Taken together, data from this part of our study thus provide experimental evidence for potential application of combination therapy using these two flavonoids.
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Complex botanical natural products: Synthesis of cephalotaxus esters and of the C19-diterpenoid skeleton of aconitum and delphinium alkaloids
… to confer differing activity profiles against vincristine resistant HL-60/RV+. The Aconitum and Delphinium alkaloids comprise a family of compounds isolated from the Aconitum and Delphinium genera. Several compounds within this class show potent Na+ ion channel activity ranging from the ion …
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Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts
… medicinal value. For example, vinblastine and vincristine from Catharanthus roseus monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents currently used in the clinic. Strictosidine synthase is a key …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
… of Cyclophosphamide, Dexamethasone and Vincristine. Furthermore, we report an <em>in vitro</em> and <em>in vivo</em> CXCR4 genetic deletion model of B-ALL cells generated using the CRISPR-Cas9 gene editing technology. The CXCR4 Knockout cells display defective chemotaxis and migration …
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Elucidating Targetable Genetic Vulnerabilities in Relapsed/Refractory Diffuse Large B-cell Lymphoma
… doxorubicin, prednisone, rituximab, and vincristine (R-CHOP); however, the relapse rate remains high, underscoring the need for improved diagnostic and therapeutic methods. In this comprehensive analysis, we investigated the genetic substructure of DLBCL in both newly diagnosed and …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… cells were resistant to doxorubicin and vincristine, but RTX rendered the Namalwa/MDR1 cells as chemosensitive as the parental Namalwa cells. RTX induced the translocation of CD20 into lipid rafts and the translocation of P-gp out of rafts. Our results supported our hypothesis that the …
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Engineering delivery systems for the treatment of Non-Hodgkin lymphoma
… (i.e., Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone), a commonly used therapeutic regimen for many Non-Hodgkin lymphomas. While therapeutic remission can occur in 50% - 80% of these patients, nearly half are expected to develop relapsing or refractory disease. There …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… used anti-mitotic drugs, vinblastine and vincristine. The common intermediate to all monoterpene indole alkaloids is strictosidine, the product of an asymmetric Pictet- Spengler condensation of tryptamine and the iridoid monoterpene secologanin. This reaction is catalyzed by the enzyme …
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Role of Actin and its regulating proteins in drug response
… LIMK expression was detected in in vivo derived vincristine resistant ALL xenografts and ALL clinical samples, further demonstrating that alterations in LIMKs and cofilin are associated with antimicrotubule drug resistance. Importantly, in chapter 4, gene silencing and drug treated clonogenic …
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