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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Vinca"”.
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An experimental investigation of coloring matter in flowers of vinca major
… the coloring matter in the flowers of Vinca Major, with the common name of periwinkle. This was done by extracting the pigment of the flowers with methanol, amyl alcohol, and crystallizing the pigment as a chloride. For this pigment, solubility, color reactions, spectra and other …
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The Role of Leaf Out Timing and Vinca Minor Invasion on a Deciduous Understory Plant Community
… investigates the effects of the invasive plant Vinca minor on the forest plant community composition under current and future climate scenarios. Field surveys at a longstanding invasion revealed that Vinca minor reduces plant diversity and alters plant community composition while increasing soil …
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Preliminary characterization of VmTPT2, a putative monoterpene indole alkaloid (MIA) transporter from Vinca minor L. (Apocynaceae)
… cloning of a similar transporter (VmTPT2) from Vinca minor was carried out and expressed in a yeast heterologous system for transport experiments and functional characterization. In planta studies involved transcript expression analysis of the early MIA biosynthetic gene VmTDC and putative …
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The Use of Ipso-dihydrodiols Enzymatically Derived from Benzoic Acid in Enantioselective Synthesis. Appoaches to Total Synthesis of Vinca Alkaloids
… The latest synthetic approaches toward vinca alkaloids are described and include the construction of model substrates for the investigation into Diels-Alder, radical cascade, and tandem Michael addition reactions as possible routes to the family of alkaloids. Also described are the …
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A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba
… are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has been found to produce a complete remission in patients …
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Localization of monoterpenoid indole alkaloid (MIA) biosynthesis by in situ hybridization (ISH)
… demonstrates that most of the MIAs of Eurasian Vinca minor, African Tabernaemontana e/egans and five Amsonia species, including North American Amsonia hubrichitii and Mediterranean A. orienta/is, accumulate in leaf wax exudates, while the rest of the leaf is almost devoid of alkaloids. …
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
… of combining currently used chemotherapy drugs (vinca alkaloids and lomustine) together to determine their effectiveness at killing canine histiocytic cells in culture. The results obtained in the first cell line studied did not show a difference in the effectiveness of these drugs when combined …
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In vitro anti-cancer effects of benzimidazoles on the canine osteosarcoma D17 cell line
… drug classes such as taxanes and vinca alkaloids, leading to metaphase arrest (G2/M phase) and tumor cell apoptosis. BZs also demonstrate indirect anti-cancer activity by vascular disruption of endothelial cells and reduction in cancer cell secretion of the angiogenic cytokine …
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Synthesis and evaluation of novel heterocyclic compounds as anticancer agents
… These binding sites include the colchicine, vinca alkaloids, rhizoxin/maytansine and tubulin sulfhydryl binding sites. Combretastatin A-4 is one of the mostpotent natural products targeting tubulin and prevents microtubule polymerisation thatleads to mitosis arrest and apoptosis in …
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Visualization of Local Anesthetic in the Pterygomandibular Space (PMS): Educational Module for Inferior Alveolar Nerve Blocks (IANBs)
… to expose where the dye had aggregated. A Vinca (DCLA-0605) caliper was used to measure the dispersion of the solution within the PMS. RESULTS: The methylene blue (PBS) dye solution aggregated in the area of the inferior alveolar and lingual nerves, indicating a successful injection. The …
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The γ-tocopherol-like family of N-methyltransferases: A taxonomically clustered gene family encoding enzymes responsible for N-methylation of monoterpene indole alkaloids
… assemblies of Catharanthus roseus (L.)G.Don, Vinca minor L., Rauwolfia serpentine (L.)Benth ex Kurz, Tabernaemontana elegans, and Amsonia hubrichtii, with the nucleotide sequence of the N-methyltransferase involved in vindoline biosynthesis, revealed eight new homologous methyltransferases. …
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Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /
… except for a single low vindoline cultivar (Vinca Mediterranean DP Orchid), they all accumulate similar levels of MIAs. Further enzymatic studies with extracts from young leaves and from developing seedlings showed that the low vindoline cultivar has a IO-fold lower tabersonine-16-hydroxylase …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… Taxanes and vinca alkaloids are widely used tubulin inhibitors in cancer chemotherapy. However, their clinical use is compromised by two major mechanisms of drug resistance: the overexpression of Pgp and bIII-tubulin. This dissertation describes the design and …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… platinum drugs, taxanes, epothilones and vinca alkaloids, but also newer agents such as bortezomib. Bortezomib (VELCADE) is a boronic acid dipeptide, which causes a selective blockade of proteasome activity. Bortezomib-induced peripheral neuropathy is an important clinical complication, …
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A potential energy-saving heat treatment for re-circulated irrigation water and its biological mechanisms
… lab assay data to the real world using annual vinca (Catharanthus roseus) and P. nicotianae as a model system. The results of these studies indicated that the water temperature required to eliminate Phytophthora and bacterial species can be lowered to 48"C from 95"C if treatment time extends to …
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… of clinically used agents such as taxanes and vinca alkaloids. A series of monocyclic pyrimidine analogs were designed and synthesized as colchicine site binding agents to overcome Pgp and β-III tubulin meditaed drug resistance.<br /> Multitargeted single agents with dual mechanism of actions, …
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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors
… over agents that target the taxane and vinca alkaloid site. Herein, we evaluated the anticancer activity of novel small-molecules that target the colchicine binding site, focusing on the most promising compounds from several structural scaffolds including indolyl-imidazopyridines (DJ95 …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… the clinically used antitubulins, taxanes and vinca alkaloids, CBSIs are less prone to several known clinical taxanes resistance mechanisms and possess improved aqueous solubility. Our lab previously reported the discovery of VERU-111, a potent and orally bioavailable CBSI with potent …