Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Vinblastine."”.
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A study comparing the effects of vincristine with those of ionizing radiation on the root meristem of Vicia faba
Vincristine and vinblastine, two closely related alkaloids are extracted from the Madagaskar Periwinkle, Vinca rosea Linn. They have been shown to be effective oncolytic agents and cause arrest of mitosis at the metaphase stage, similar to that of colchicine andcolcimid. Clinically, vincristine has …
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Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
… cells (LS-180) were treated for 72 hours with vinblastine alone and in the presence of ritonavir. The expression of efflux transporters (MDR1 and MRP2), metabolizing enzyme (CYP3A4) and nuclear hormone receptor (PXR) was induced in response to vinblastine. This overexpression was completely …
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Anti – Cancer effects of Momordica charantia in- vitro
… measured the effect of either temozolomide or vinblastine alone or combining each with either the crude water soluble extract of M. charantia or α β momorcharin measuring cell viability in the different cell lines. Furthermore, the present study investigated the cellular mechanism(s) via which …
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Bioreactor design for scaleup of Catharanthus roseus hairy root cultures for production of indole alkaloids
… anticancer indole alkaloids, vincristine and vinblastine. Hairy root cultures are an attractive alternative for the production of plant derived secondary metabolites. C. roseus hairy root cultures were established in our laboratory by A. rhizogenes mediated transformation of C. roseus …
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Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /
… of the monoterpenoid indole alkaloids (MIA) vinblastine and vincristine, which are key pharmaceutical compounds that are used to combat a number of different cancers. Therefore, procurement of the antineoplastic agents is difficult but essential procedure. Alternatively, CatharanthllS tissue …
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Roles of Nanog, a transcription factor for self-renewal of embryonic stem cells, in prostate tumor initiation and chemoresistance
… cells presented increased resistance to Taxol, vinblastine, and doxorubicin. Profiling of genes in drug resistance and metabolism revealed a marked increase in the mRNA level of ATP-binding cassette (ABC) efflux transporters B1 and G2 in tumor cells enriched with endogenous Nanog expression. The …
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Microtubule Regulation of Mitochondrial Bioenergetics in Cardiac and Skeletal Muscles
… while in-vivo treatment with paclitaxel, and vinblastine resulted in creatine independent mitochondrial impairments. Second, in-vivo paclitaxel administration surprisingly increased hind-limb torque and II-tubulin-VDAC2 interaction in soleus while eliciting minor inhibitions of ADP-dependent …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
… three anticancer drugs (etoposide, topotecan and vinblastine) were observed in the presence of moxifloxacin across model cell lines suggesting moxifloxacin mediated evasion of efflux pumps. Significant reductions in efflux ratio of these anticancer agents were also observed in the presence of …
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Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts
… products with medicinal value. For example, vinblastine and vincristine from Catharanthus roseus monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents currently used in the clinic. Strictosidine …
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A P-glycoprotein-like mechanism in the nicotine-resistant insect, Manduca sexta.
… to transport a known P-glycoprotein substrate, vinblastine. The tubules were not only able to transport radiolabelled vinblastine, but this transport was also inhibited by verapamil. P-glycoprotein is localized to the digestive tracts of mammals and of invertebrates, where it is thought to act …
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Plant aromatic amino acid decarboxylases: Evolutionary divergence, physiological function, structure function relationships and biochemical properties
… (including the pharmacologically active vinblastine and quinine), benzylisoquinoline alkaloids (including the pharmacologically active papaverine, codeine, morphine, and sanguinarine), and antioxidant and chemotherapeutic amides. Recent studies of plant AAAD proteins demonstrated that in …
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The Effect Of Leucogenenol and Chemotherapy on B and T Lymphocyte Populations in Mice Infected With Friend Virus Leukemia
… chemotherapy of arabinosyl cytosine and vinblastine on the Band T lymphocyte populations of mice infected with Friend virus leukemia. Procedure. Isolated lymphocyte populations were quantitated using a cytotoxic assay for T lymphs and a direct immunofluorescent technique for B lymphs. …
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Discovery, characterization, and rational design of the enzymes involved in monoterpene indole alkaloid biosynthesis in Madagascar periwinkle
… the clinically used anti-mitotic drugs, vinblastine and vincristine. The common intermediate to all monoterpene indole alkaloids is strictosidine, the product of an asymmetric Pictet- Spengler condensation of tryptamine and the iridoid monoterpene secologanin. This reaction is catalyzed …
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Understanding and manipulating alkaloid biosynthesis
… the Neolithic Era. Today, alkaloids such as vinblastine (isolated from Catharanthus roseus) and morphine (isolated from Papaver somniferum) are prescribed to treat various cancers and relieve pain, respectively. Despite this storied use and palpable presence in the current pharmacopeia, …
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The γ-tocopherol-like family of N-methyltransferases: A taxonomically clustered gene family encoding enzymes responsible for N-methylation of monoterpene indole alkaloids
… potent anti-neoplastic molecules vincristine and vinblastine is the aspidosperma alkaloid, vindoline. Vindoline accumulates to trace levels under natural conditions. Research programs have determined that there is significant developmental and light regulation involved in the biosynthesis of this …
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Functional Characterization of Monoterpenoid Indole Alkaloid (MIA) Biosynthetic Genes in Catharanthus roseus
… and vindoline that dimerize to form anticancer vinblastine and vincristine. While their assembly is still poorly understood, the complex multistep pathways involved occur in several specialized cell types within leaves that are regulated by developmental and environmental cues. The organization …
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Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants
… value, such as the anticancer agents vinblastine and vincristine. Unnatural modifications can impart novel bioactivity to the parent natural product. Advances in synthetic biology and microbial engineering have allowed overproduction of natural products and their analogs in non-native …
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Purification and substrate specificity of new C. roseus enzymes
… Many TIAs have medicinal uses; for example, vinblastine has anti-cancer activity and ajmaline has anti-arrhythmic activity. Many TIAs did not evolve to treat human disease, however, and thus most likely do not have optimal pharmacological properties. If TIAs could be modified, the novel TIAs …
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The relationship between p53 mutations and differential sensitivity to anti-cancer drugs in oesophageal cancer cell lines
… to cisplatin and transplatin, but sensitive to vinblastine, vincristine, 5-fluorouracil and 5-fluorouridine. HCu-13 was sensitive to cisplatin and transplatin, but resistant to the other drugs. WHCO1 was of intermediate sensitivity, while all the cell lines were senstitive to doxorubicin. …
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Role of BCL-XL in cell death after spinal cord injury
… in SCI-induced decreases of Bcl-xL levels. Vinblastine-induced apoptosis of neuronal PC12 cells, showed that cytosolic phosphorylated Bcl-xL correlated with apoptotic cell death of neurons, suggestive of Bcl-xL-phosphorylation as a pro-apoptotic event. I found that activated …
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