Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Vesicular trafficking"”.
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Characterisation of the role of VPS33B in Vesicular trafficking in polarised Epithelial cells.
… that a VPS33B-POLARINRab11a intracellular trafficking pathway is functionally distinct from another VPS33-related pathway (VPS33A/VPS16) and is required for (a) normal epithelial polarisation and apical junction complex formation, and (b) normal liver and kidney development and function.
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
… be sufficient in restoring the distribution of vesicular trafficking proteins that promote the biogenesis of an organelle unique to sperm, the acrosome. In contrast, ARA was much less effective than DHA in restoring germ cell adhesion integrity. Assessments of cell-cell contacts which form …
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Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
… controlling actin rearrangements and directed vesicular trafficking. Actin remodeling and vesicular trafficking events are in turn, implicated functions of a variety of small GTPases of the Ras superfamily, which include the Rho and Arf subfamilies. Thus towards efforts of further …
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Retrograde regulation of activity-dependent synaptic growth by Synaptotagmin 4
… be a general regulator of postsynaptic vesicle trafficking. Syt 4 mRNA and protein levels are bi-directionally regulated by neuronal activity, with seizure induction increasing Syt 4 levels and decreased activity reducing Syt 4 expression. Bi-directional manipulations of postsynaptic Syt 4 …
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Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
… of this process. Our aim was to identify trafficking pathways that regulate Col IV deposition during angiogenic blood vessel development. We have identified the GTPase Rab10 as a major regulator of Col IV vesicular trafficking during vascular development using both <em>in vitro</em> …
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Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
… however, the molecular events that regulate trafficking and fusion of micronemes with the plasma membrane remain unresolved. In this thesis, I describe the discovery and characterization of a regulator of microneme exocytosis in Toxoplasma gondii. In the first chapter, I introduce T. gondii …
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Investigating the Biological Functions of the Protein Kinase WNK1 in the Regulation of Cytoskeletal Structures and Membrane Trafficking
… phenotypes. Second, I examined WNK1 and membrane trafficking events. Depletion of WNK1 caused higher amount of epidermal growth factor receptors remained at the later step of endocytosis. Lysosomes and lysosome-related organelles were disrupted. Biochemical assay suggested that WNK1 could …
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The Proteomic Response of Gill Tissue in Tidally and Subtidally-Acclimated California Mussels, Mytilus californianus, to Acute Emersion-Induced Anoxia
… more responsive to changes in cytoskeletal and vesicular trafficking dynamics in response to acute anoxia. Together, our analysis showed that proteostasis, energy metabolism, oxidative stress and cytoskeletal and trafficking processes are all involved in priming tidally-acclimated mussels to …
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Circadian and Circatidal Rhythms of Protein Abundance in the Intertidal Mussel Mytilus californianus
… components, ER protein processing and vesicular trafficking, extracellular matrix and immune proteins, and oxidative stress and chaperoning proteins. We also found evidence that post-translational modifications may be important for driving these rhythms, as acetylation and …
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Modulation of innate immune responses in nasopharyngeal epithelial cells by the Epstein-Barr virus (EBV)-encoded latent membrane proteins LMP2A and LMP2B
… a role for LMP2A and LMP2B in the control of vesicular trafficking, with both proteins increasing endosomal-lysosomal trafficking and lysosomal acidification, an effect that important for degradation and turnover of receptors. These data present novel mechanisms by which EBV may evade immune …
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β-cell dysfunction in Huntington's disease
… cell dysfunction in our model. Next we analyzed vesicular trafficking as this has been found aberrant in HD and is vital for sustained insulin release. These studies showed that the transport of insulin granules along microtubule filaments is perturbed. Furthermore, we found that mutant …
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Dynamics and Fate of the inner Membrane Complex in Apicomplexan Parasites
… appears to arise from the Golgi apparatus, via vesicular trafficking machinery. We have therefore examined SNARE proteins potentially involved in the biogenesis of the IMC. Genome wide analysis and phylogenetic reconstruction permitted classification of apicomplexan putative SNAREs (25 In T. …
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Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates <em>Chlamydia trachomatis</em> Persistence via a Novel Pathway.
… indoleamine 2, 3-dioxygenase; iii) inhibition of vesicular trafficking or sphingomyelin transport to the inclusion or; iv) amino acid, iron or glucose deprivation. These data demonstrate that co-infection-induced persistence is mediated by a previously undescribed, novel mechanism. During …
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Microtubule interactions and regulation of the mitotic kinesin-like protein-1 and kinesin-like calmodulin-binding protein
… within eukaryotic cells including organelle and vesicular trafficking, motility of cilia and flagella, and mitosis. Microtubules operate in conjunction with the kinesin superfamily of microtubule-dependent motor proteins, which use the energy from ATP hydrolysis to "walk" along microtubule …
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The Functions of Autophagy Genes in Lymphocytes and Osteoclasts
… degrading damaged organelles, and regulating vesicular trafficking. To study the role of autophagy in primary cells with important physiologic functions, we generated mice lacking essential autophagy genes in B lymphocytes, T lymphocytes, and osteoclasts. We found that the essential autophagy …
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Viral subversion of host cell membrane trafficking
… crucial for endocytosis and intracellular vesicular trafficking, was examined by structural, biochemical and biophysical techniques. Co-crystal structures of NTD bound to HDAg-L peptides derived from different HDV genotypes revealed that HDV interacts with multiple binding sites on NTD …
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ENDOCYTIC CONTROL OF CELL-AUTONOMOUS AND NON-CELL-AUTONOMOUS FUNCTIONS OF P53
… signaling, a process achieved via endocytic trafficking. Subsequently, NUMB has emerged as a significant tumor suppressor, particularly in the context of breast cancer, where it stabilizes the critical tumor suppressor protein p53 by inhibiting its targeting to proteasomal degradation by the …
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The Structural and Biochemical Characterization of Salmonella Host Specificity Determinant Gifsy-2 Gene E
… a diverse host repertoire. GtgE modulates vesicular trafficking of the Salmonella-containing vacuole by cleaving Rab GTPases, Rab29, Rab32, and Rab38, thereby preventing the delivery of antimicrobial products to the vacuole. In order to gain an understanding of GtgE's proteolytic mechanism, …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… protein involved in the regulation of vesicular trafficking, in a glucose-dependent manner and favors its recruitment to the primary cilium, an antenna-like structure acting as signalling platform to control hormone secretion. Interestingly, LRRK2 controls the ciliary recruitment of …
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Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages
… in protein degradation but also in vesicle trafficking and immune signalling. <br/>My data shows that phagosomes are enriched in polyubiquitylation, which is further enhanced by IFN-ɣ. I applied a targeted AQUA peptide approach by which we quantified ubiquitin chain linkage peptides from …
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