Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Vesicle trafficking"”.
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Dysfunction of ciliary vesicle trafficking in ciliopathies
Contains fulltext : 181326.pdf (Publisher’s version ) (Open Access)
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
… in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the terminal and re-organization for reuse. Thus, synaptic vesicle trafficking is of interest as to where presynaptic regulations of synaptic …
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Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
Most vesicles within a synapse are dormant. The rest participate in synaptic neurotransmission, with a portion of these preferentially fusing first. Moreover, all synapses experience spontaneous neurotransmitter release which may originate from the random exocytosis of vesicles prepared to fuse …
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Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages
… only involved in protein degradation but also in vesicle trafficking and immune signalling. <br/>My data shows that phagosomes are enriched in polyubiquitylation, which is further enhanced by IFN-ɣ. I applied a targeted AQUA peptide approach by which we quantified ubiquitin chain linkage peptides …
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Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
… of this process. Our aim was to identify trafficking pathways that regulate Col IV deposition during angiogenic blood vessel development. We have identified the GTPase Rab10 as a major regulator of Col IV vesicular trafficking during vascular development using both <em>in vitro</em> …
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An investigation of the function of adaptor protein complex 4 (AP-4)
Vesicle trafficking provides the solution to the ‘sorting problem’ – how the eukaryotic cell maintains the distinct identities, and thus functional properties, of its membrane-bound organelles. During vesicle trafficking, proteins are selectively sorted into membrane bound transport intermediates …
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Biochemical and Genetic Studies of Beclin 1 Function in Autophagy
… (PtdIns) 3-kinase and mediates multiple vesicle trafficking pathways including autophagy and endocytosis. However the precise role of Beclin 1 in autophagy regulation is not well understood and information is lacking regarding the function of Beclin 1 in neuronal development and …
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Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum
… which it transports within double membrane vesicles to the digestive vacuole, where digestion occurs and metabolites are used mostly for nutritional purposes. To gain a deeper understanding of the molecular basis and mechanisms of this vital process, a panel of inhibitors was used to inhibit …
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
… mediator of diverse membrane processes including vesicle trafficking, actin cytoskeleton dynamics and cell signaling at the cell surface, indicating significance of spatiotemporal regulation and underlying mechanism of PIP2 concentration. So far, most studies on PIP2 generation have focused on how …
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An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11
… superfamily and are key regulators of membrane trafficking within the cell. There are over 60 members of the Rab family which localise to specific membrane compartments and interact with effector proteins to regulate membrane trafficking processes, such as vesicle formation, vesicle trafficking …
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Investigating the regulation of the PCTAIRE-1 protein kinase : a new target of AMP-activated protein kinase and beyond?
… Proposed physiological functions include vesicle trafficking and neurite outgrowth, however, no consensus substrate motif has been identified to date, and there are no confirmed physiological substrates. We have identified PCTK1 as a potential substrate of AMPK, a master kinase regulating …
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SNARE specificity in membrane protein traffic
… channel regulation. With the discovery of the vesicle trafficking SNARE protein NtSYP121 came the development of the predicted cytosolic domain fragment of the protein. This Sp2 fragment was found in studies to block the responses of guard cell K+ and Cl- channels to ABA. These observations …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
… cytoskeletal regulation and intracellular vesicle trafficking. Recently, it was reported that PI(4,5)P2 was important for neurodegenerative diseases. Nevertheless, expression and regulatory role of PIP5KIs in rat primary glia cell remain poorly understood. This present study has shown that …
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RNA binding proteins in neurotoxic protein clearance
… contents are sequestered in double membraned vesicles and delivered to lysosomes for proteolytic degradation. Dysfunction in the autophagic machinery or in the lysosomes is a hallmark of numerous neurodegenerative diseases, including Parkinson’s disease (PD). Deficient clearance of damaged …
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Rab11 Regulates Lumen Formation and Morphogenesis in the Developing Pancreas
… are due, at least in part, to failures in vesicle trafficking, as apical components remain trapped within Rab11pancDKO cells. These observations suggest Rab11 directly regulates epithelial lumen formation and morphogenesis, which are in turn critical for pancreatic cell fate specification. …
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With No Lysine (WNK) Family Proteins and Their Interaction with Downstream Kinases
… and numerous downstream effectors that regulate vesicle trafficking, membrane protein localization, and ion handling. This study shows that WNK2 is also a functioning protein kinase with the same unusual kinase domain architecture and regulation by an autoinhibitory region. Like WNK1, WNK2 is …
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Retrograde regulation of activity-dependent synaptic growth by Synaptotagmin 4
… the role of presynaptic Ca2+ in triggering vesicle fusion is established, molecular mechanisms that underlie responses to postsynaptic Ca2+ remain unknown. The Synaptotagmin family of Ca2+ sensors includes several evolutionarily conserved neuronal isoforms that are predicted to regulate …
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A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… been validated by CRISPR/Cas9 targeting. Three vesicle trafficking genes, Myo1d, Smcr8, and Tvp23b, were selected for mechanistic evaluation. MYO1D is a class I myosin that binds both actin and lipid. MYO1D localizes to the basolateral membrane of enterocytes and functions in the intestinal …
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The role of cell division during tissue morphogenesis
… the zebrafish left-right organizer, Kupffer’s vesicle (KV) is used as a model to investigate the role of cytokinesis and abscission during de novo lumen formation. The cytokinetic bridge places at the center of the developing KV rosette, where it acts as a landmark for Rab11-mediated vesicle …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… an octomeric protein complex involved in vesicle trafficking, is implicated in numerous cellular processes, yet its role in cardiomyocyte plasticity is unknown. Here, I set out to explore the role of small G protein-dependent membrane trafficking in stress-induced cardiomyocyte remodeling …
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