Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Vesicle Transport"”.
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Neurons under tension: A study of vesicle dynamics
… and present my Ph.D. research on the dynamics of vesicles in neurons under tension. To understand the role of mechanics in neuron function, we must take a closer look at the underlying subcellular dynamics. The basic goal of this research is to explore the currently unknown relationship between …
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Characterization of Novel Neuronal Antigens in the Central Nervous System of Manduca Sexta
… mitotic property of mitotic cells through active vesicle transport in the Golgi complex.
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HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells
… components to facilitate directed organelle and vesicle transport. This ultimately establishes a persistent leading edge and represses random migration. Given that tubulin is a known substrate of HDAC6 and since microtubules (MTs) are known to play an important role in polarization of …
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Nuclear Translocation of Met Via Internet Mechanism
… MET holoreceptor via a membrane-bound vesicle transport mechanism in breast cancer cells. Our findings provide a putative mechanism by which breast cancer cells adapt to oxidative stress.</p>
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Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM
… the cell by proteins which are integral membrane transporters. Escherichia coli MDR transporter, MdtM, is a previously uncharacterised, 410 amino acid residues protein from the ubiquitous major facilitator superfamily (MFS). This thesis focuses on the purification and characterisation of MdtM. …
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Protein -Protein Interactions of Synucleins: Implications for Normal Function and Neurodegenerative Disease
… that is involved in cell signaling, vesicle transport, and mitogenesis. Alpha-synuclein's inhibitory capacity is dependent upon a lipid vesicle-induced conformational shift to alpha-helix. Inhibition of PLD2 also requires a portion of the acidic C-terminus, which may directly interact …
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Molecular bases of scouting behavior in honey bees
… antagonists decreased it. Blocking glutamate vesicle transport inhibited the behavioral effect of glutamate. I further hypothesize that scouts who seek food sources and those who seek nest sites would share a common “molecular signature” in their brains. Behavioral analysis showed that …
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Characterising the molecular response of Agaricus bisporus to mushroom virus X infection
… increased regulation in gene expression, vesicle transport and ER-stress responses in virus infected fruit bodies, with less susceptible strains revealing increases of antiviral protein responses, general stress responses, lipid metabolism. The intracellular localisation of two of these …
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Probing the formation of mammalian cell lipid microdomains with nanometer-scale imaging secondary ion mass spectrometry
… significant domains. In addition, the rapid transport of sphingolipids to the plasma membrane has made for complex interpretation of the role that vesicle transport plays in domain formation. Further studies using this methodology of chemically imaging mammalian cells, most importantly …
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3D localization of cytoskeleton in mouse spermatids using stochastic optical reconstruction microscopy
… of the acrosome and the manchette, protein and vesicle transport in spermatids, and sperm head shaping are crucial steps in the formation of healthy sperms. The cytoskeleton in spermatids plays a crucial role in shaping the sperm head. The acroplaxome exerts forces on the nucleus and gives the …
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Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1
… in the presynaptic boutons and axonal vesicle transport at the presynaptic compartment. They also seem to contribute to the spectrin-actin cytoskeleton stabilization at the postsynaptic compartment of the NMJ. Lastly, we reported that reduced levels of Sac1 phosphatase cause progressive …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… cascades ranging from the insulin response and vesicle transport to xenophagy and anti-viral immunity. Increasingly, however, TBK1 dysregulation has been linked to autoimmune disorders and cancers, heightening the need to understand regulatory controls of TBK1. As a result, this dissertation …
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Genetic Analysis of Grinder Formation in Caenorhabditis Elegans: Regulation by RAB-6.2 and Its GTPase Activating Protein EAT-17
… currently understood. Rabs are key regulators of vesicle transport, and cycle between active, GTP bound and inactive, GDP bound states. GTPase activating proteins (GAPs) catalyze the hydrolysis of GTP, allowing Rabs to be extracted from membranes and recycled for additional rounds of signaling. I …
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DROSOPHILA CLASS-I MYOSINS THAT CAN IMPACT LEFT-RIGHT ASYMMETRY HAVE DISTINCT ATPASE KINETICS
… MgADP release and can power small unilamellar vesicle transport, supporting a function as a transporter. Amazingly, both paralogs have nanomolar MgADP affinity and are the first class-I myosins identified as high duty ratio motors. In addition, I participated in a collaboration project …
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Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… specific membrane trafficking steps including vesicle\r\nbudding, vesicle transport and fusion with downstream target compartments. Rab\r\nfunction is mediated by the cyclical binding and hydrolysis of GTP, which in turn\r\nregulates the recruitment of downstream effector molecules directly …
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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
… needed for cell division and intracellular vesicle transport. I confirmed the predicted binding mode of spastazoline analogs by X-ray crystallography and used these high-resolution structural models, along with biochemical analyses of spastin mutant alleles, to design an allele-specific …
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Domänenanalyse des Cyclase-assoziierten Proteins (CAP) und Charakterisierung von Filactin, einem neuartigen actinähnlichen Protein aus Dictyostelium discoideum
… dependent changes in the actin cytoskeleton, in vesicle transport and cell development. The binding of monomeric actin through the C-terminal domain represents a common feature of all CAPs. From four highly conserved regions in this domain the verprolin homology region of the D. discoideum CAP …
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Studies of viral and cellular proteins involved in herpes simplex virus type-1 egress
… Nipsnap2 have been proposed to contribute in vesicle transport and membrane fusion in cells. Using CRISPR-Cas9 technology these proteins were knocked out in a keratinocyte cell line (HaCaT) to investigate their role in HSV-1 egress. However, little or no effect on HSV-1 egress could be …
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Structural study of lipid bicontinuous cubic phases for cellular delivery
… due to its nontoxicity and resemblance of vesicle transport systems in the cell, such as exosome. Primary formulation of lipid based delivery system is vesicle, called liposome. By modulating lipid composition in the liposome formulation, drug release kinetics can be optimized. There are …
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Characterization of Fluorescent biosensor for Rab11 GTPase
L'abstract è presente nell'allegato / the abstract is in the attachment
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