Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 723 for “"Vertebrate"”.
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Phylogenomics of vertebrate serpins
… the eukaryotes, the prokaryotes and the archea. Vertebrate serpins can be conveniently classified into six groups (V1 - V6), based on three independent biological features - gene organization, diagnostic amino acid sites and rare indels. In the present work, the phylogenetic relationships of …
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Molecular Basis of Vertebrate Embryonic Migration
<p>Embryology aims at understanding how a single fertilized cell develops into a complex multicellular organism. Initially the embryo is no more than a ball of cells where the three primordial layers, the ectoderm, mesoderm and the endoderm are one on top of the other. The three germ layers will go …
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Basal constriction : shaping the vertebrate brain
… morphogenesis of a major conserved bend in the vertebrate neural tube, the midbrain-hindbrain boundary constriction (MHBC). The MHBC forms between 17 and 24 hours post fertilization in zebrafish, concomitant with, but independent of ventricle inflation. Cells shorten to 75% the length of the …
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Tritiated Saxitoxin Binding in the Vertebrate Heart
Labelled toxins such as ('3)H-STX which selectively bind to the sodium channel have been used to estimate the density of channels on the membrane. While many biochemical investigations of excitable tissues have been made on nerve, skeletal muscle or electric organ with ('3)H-STX, relatively little …
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High-throughput vertebrate total analysis/screening platform
… screening on whole complex organisms, such as vertebrates. To address this issue, a high-throughput platform as a vertebrate total analysis/screening system (V-TAS) is proposed. This platform consists of two independent parts: an automated imaging system and an automated microinjection system. …
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Biochemical Analysis of Evolutionary Divergent Vertebrate Larp6 Proteins
… to carry out detailed biochemical analyses of vertebrate LARP6 RNA binding activity. The purpose is to determine if there is a species-specific protein-RNA interaction due to co- evolution of the ligand-binding surface within the LARP6 RRM and the RNA ligand sequence and/or structure. …
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
Roles of neurogenin and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target …
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Characterization of DNA Binding Activities at Vertebrate Telomeres
… are central to telomere function. Two types of vertebrate DNA binding activities are characterized in this thesis: proteins that can potentially bind to the 3' overhang of TTAGGG repeats and proteins that bind to duplex telomeric DNA. We have identified, characterized and partially purified an …
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The role of pax genes in vertebrate segmentation
Pax genes are involved in a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the …
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Role of O-GlcNAc in the Vertebrate Secretory Pathway
… are required for its function in human cells and vertebrate development, because mutation of these sites impairs SEC23A-dependent in vivo collagen trafficking and skeletogenesis in a zebrafish model of cranio-lenticulo-sutural dysplasia (CLSD). </p><p> Next, we developed a proteomic workflow to …
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Vertebrate Faunal Analysis of The Anderson Creek Site (45KP233)
The Anderson Creek archaeological site (45KP233) was excavated by the Washington State Department of Transportation (WSDOT) in 2015, as part of a fish passage replacement project in Puget Sound. Faunal analysis of remains from this excavation was completed by the author in collaboration with Dr. …
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Protein Coevolution and Coadaptation in the Vertebrate bc1 Complex
The cytochrome bc1 complex of the mitochondrial electron transport chain accomplishes the enzymatic reaction known as the modified Q-cycle. In the Q-cycle the bc1 complex transports protons from the matrix to the intermembrane space of the mitochondria, creating the proton gradient used to make …
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Quantifying evolution and natural selection in vertebrate noncoding sequence
… especially those of various mammals and other vertebrates, enables us to develop alternative methods for analyzing molecular evolution and selection that rely on noncoding sequence. Furthermore, our greater understanding of the importance of noncoding DNA demands such methods. This thesis …
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A screen for novel interactions within the vertebrate centriole
… of 3025 binary test pairs amongst a subset of 55 vertebrate centriole/centriole associated proteins. The screen detected 28% of the interactions identified already in the literature and further identified 67 novel binary PPIs within the vertebrate centriole. Of these, 13 are likely to be …
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The development and evolution of vertebrate oxygen-sensing cells
Oxygen-sensing cells release neurotransmitters, including serotonin, in response to hypoxia in the blood or surrounding air/water. This stimulates the glossopharyngeal and/or vagal nerves, triggering increased ventilation via the respiratory reflex. In the adult, they are located in the carotid …
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Characterising the function of CDK5RAP2 in the vertebrate centrosome
… is the major microtubule organising centre in vertebrate cells. CDK5RAP2 is a human protein that localises to the centrosome. At the start of this thesis work, the function of CDK5RAP2 was uncharacterised. Significantly, cdk5rap2 is one of several centrosomal genes that are mutated in the …
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Towards mapping spatial transcriptome of an entire vertebrate brain
… mapping the spatial transcriptome of an entire vertebrate brain.
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IDENTIFICATION AND CHARACTERISATION OF POTENTIALLY NOVEL HERPESVIRUSES IN VERTEBRATE SPECIES
… of viruses that can infect a broad spectrum of vertebrate hosts, ranging from fish to mammals. The structural unit of these viruses, known as the virion, contains a linear, double-stranded DNA genome that is encapsulated within an icosahedral capsid, which is further surrounded by a protein …
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APP∙CNTN Complex Architecture is Conserved Throughout the Vertebrate Lineage
… of these interactions is conserved throughout vertebrates. Furthermore, we have quantified these interactions and have determined their kinetics to be rapid and of weak to moderate affinity. Finally, we present data suggesting that APP family-CNTN complexes are intimately involved in the …
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