Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Ventricular Remodeling"”.
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Tetralogy of Fallot Surgical Repair and Associated Right Ventricular Remodeling
… type of surgical repair strategy and late right ventricular health. However, surgical practices remain unchanged and led by institution-level biases. The body of evidence addressing outcomes based on TOF surgical repair strategy is weak and controversies persists on the management of these …
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Artificial muscle technology applied towards treating ischemic mitral regurgitation caused by left ventricular remodeling
… MR is most often caused by the bulging, or remodeling, of the heart's left ventricle. This remodeling displaces the papillary muscles inside of the ventricle and tethers the mitral valve, preventing it from closing properly. Current treatments attempt to either repair or replace the valve. …
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Aortic Valve Replacement: The Influence of Prosthesis-Patient Mismatch for Left Ventricular Remodeling, Cardiac Function and Survival
… hemodynamics with secondary impaired left ventricular remodeling. Nevertheless, an increasing number of studies with various study designs and outcomes present conflicting results. Thus, there is no convincing evidence for PPM’s detrimental effects. The aims of this research were to …
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EFFECTS OF DAPAGLIFLOZIN ON EXERCISE CAPACITY, RESPIRATORY FUNCTION, BIOMARKERS, SLEEP APNEA, AND LEFT VENTRICULAR REMODELING IN PATIENTS WITH HEART FAILURE: A PROSPECTIVE, SINGLE CENTER, NON RANDOMIZED STUDY
… full follow-up. Dapagliflozin improved left ventricular ejection fraction (LVEF), reduced cardiac volumes and pulmonary artery pressures, and enhanced ventilatory efficiency (VE/VCO2 slope). Haemoglobin increased significantly, while peakVO2, natriuretic peptides, and spirometry remained …
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Vergleichende Beurteilung verschiedener echokardiographischer und elektrokardiographischer Parameter zur Vorhersage der Erholung der linksventrikulären Funktion bei Patienten mit akutem St-Hebungsinfarkt
… were regarded to the recovery of left ventricular function and the formation of a left ventricular remodeling. The identified perfusion-scores have shown that they can be applied to evaluate an individual patient prognosis regarding the extent of remaining restrictions of the …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… hypertension has long been known to cause left ventricular remodeling. Although previous studies pointed towards inflammation as the pathological driver of cardiac remodeling, the exact mechanistic pathway associated with pressure overload-induced cardiac remodeling remains to be elucidated. In …
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The role of pulmonary arterial stiffness in right ventricular remodelling in COPD
… therapeutic target before end stage arterial remodeling occurs. Traditionally the assessment of the arterial stiffness required right heart catheterization, however recent advance in MRI are yielding new opportunities to undertake this assessment noninvasively. Pulse wave velocity is one of …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
<p>During evolution of adverse ventricular remodeling that culminates in cardiomyopathy and congestive heart failure, myocardial fuel utilization becomes inefficient and inflexible, and mechanistic studies in pre-clinical models indicate that altered substrate and energy metabolism can cause …
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Soft Robotic Platforms for the Simulation of Cardiovascular Disease and Device Development
… model of AS, which was leveraged to investigate ventricular remodeling and plasticity due to the cessation of the biomechanical stimuli induced by the aortic sleeve. This thesis then presents the design and development of a soft robotic cardiac sleeve that can tunably recapitulate loss of cardiac …
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The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… study were to investigate how alterations in ventricular capillarity affect contractile performance and substrate metabolism in the isolated rat heart. It was hypothesised that, if cardiac contractile performance and substrate utilisation are directly related to ventricular capillarity then …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… effects on myocardial hypertrophy and fibrosis (ventricular remodeling) in hypertension. However, ACE has other substrates in addition to ANG I, including kinins (which are potent vasodilators); thus, the mechanism of ACE's action may be more complex than mere blockade of ANG II formation. To …
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Methods and adaptations required to perform small-animal MRI scanning using a large bore clinical MRI
… blood, respectively, in healthy rats and MR left ventricular mass (LVM) was highly correlated with (r=0.87) with post-mortem mass. In the second part of the study, left ventricular remodeling (LVR) was investigated in a nonreperfused model of myocardial infarction (MI) in 5 sham and 7 infarcted …
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Dynamic Remodeling of The Stressed Heart: Role of Protein Degradation Pathways
… composition of heart muscle during hypertrophic remodeling. My study hypothesized that cardiac remodeling in response to hypertrophic stimuli is a dynamic process that requires activation of highly regulated mechanisms of protein degradation as much as it requires protein synthesis. My first aim …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the systemic circulation. We therefore synthesized various novel beta-adrenergic receptor compounds and screened these compounds in vitro for their ability to reduce markers of inflammation and apoptosis. Of the …
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Association of African Ancestry with Electrocardiographic Voltage and Concentric Left Ventricular Hypertrophy: The Dallas Heart Study
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Protective Effects of Yuzu and Its Component against Cardiovascular Disease
Left ventricular (LV) remodeling, which includes ventricular dilatation and increased interstitial fibrosis after myocardial infarction (MI), is the critical process underlying the progression to heart failure (HF). Therefore, a novel approach for preventing LV remodeling after MI is highly …
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Molecular Mechanisms That Govern Human Cardiac Stem Cell Age Disparity
<p>Transplantation of adult endogenous cardiovascular progenitor cells for heart repair results in some clinical benefit, however these stem cells lack the regenerative capacity unique to neonatal cardiovascular stem cells. The goal of this work was to identify mechanisms that contribute to the …