Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Ventral Hippocampus"”.
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Reward-related neural activity in ventral hippocampus
기억과 학습에 관여하는 것으로 알려진 해마는 공간적 정보를 처리한다고 알려져 있다. 해마는 해부학적으로 암몬각과 치아이랑으로 이루어져 있으며 특히 암몬각은 4개의 부위로 이루어져 있다. 이 중에 가장 많이 연구된 부분은 CA1이다. 해마는 크게 두 부분으로 나눌 수 있는데 배측해마와 복측해마로 나눌 수 있다. 이 두 부위는 다른 역할을 하는 것으로 알려져 있다. 최근 들어 해마와 보상의 연관성에 대한 연구가 많이 이루어지고 있으나 정확한 연관관계가 밝혀지지 않았다. 그래서 본 실험에서 복측해마에 초점을 맞추어 복측해마의 보상에 …
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Anatomical and Functional Characterization of the Ventral Hippocampus in a Rodent Model of Schizophrenia Neuropathology
… no cure. Many studies have implicated the hippocampus and the parahippocampal region as a place of both primary pathology in the disease and as regions correlated to symptom severity. To better understand the pathophysiology of the region and potentially uncover mechanisms of the disease, …
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Investigating the Role of Neuropeptide Y in the Ventral Hippocampus in Regulating Rats’ Elevated Plus-Maze and Shock-Probe Burying Behaviours
… However, its anxiety-associated effects in the ventral hippocampus are not well known, even though this structure is also heavily implicated in anxiety regulation. The goal of this thesis was to investigate whether neuropeptide Y and its Y1 and Y2 receptors are associated with anxiety regulation …
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Adversity in early adolescence alters female rats' anxiety-related behaviours and serotonergic innervation profiles in adulthood
… in the medial prefrontal cortex (mPFC) and ventral hippocampus. Administration of IPS (i.e., water immersion, elevated platform, foot shock) in early adolescence increased rats’ anxiety-like behaviour in the elevated plus-maze but had no effects in the shock-probe burying test. In the social …
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Haloperidol-Environment Interaction Modulates Expression of c-Fos Proteins in the Basal Ganglia in Rats
… neurons in the nucleus accumbens core and ventral pallidum was significantly lower in the Paired rats than in the Unpaired and Saline rats, even though all groups received haloperidol on the test day. Compared to the Saline group both the Paired and Unpaired groups showed evidence of lower …
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The Effect of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Glucose Metabolism and Epileptogenesis in the Rat
… connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the …
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The effect of voluntary exercise on adult hippocampal neurogenesis in maternally separated rats
… sections from 3.84 to 2.76 mm were analyzed as ventral. The marker, EdU was detected in rat brains using t he Click-iT EdU Alexa Fluor 488 detection kit. Three molecular marker combinations were used to detect different factors for both dorsal and ventral hippocampi: (1) EdU/GFAP/NeuN, to …
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The long-term effects of reproductive experience on the neurobiology of anxiety and its treatment: a cross species approach in female rats and women
… hormone) in the basolateral amygdala and ventral hippocampus. Chapter 3 showed that the estrous cycle impacted diazepam (a benzodiazepine) sensitivity in nulliparous rats, but not primiparous rats. Chapter 4 compared the effects of chronic fluoxetine (an SSRI, the first-line …
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An Examination Of The Persistence Of Kindling, A Model For Neural Plasticity
… in the amygdala with animals kindled in the ventral hippocampus. The AD measures showed that the hippocampal group had either similar fallback or, in the case of duration, slightly more robust retention. Experiment Four examined the question of whether the parameters of the stimulus used to …
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Enduring Effects of Early Life Inflammation on Stress-related Microglial, Neuronal and Behavioral phenotypes
… stress-related transcript abundances in the ventral hippocampus (vHPC) in a manner conducive to potentiating neural stress responses. Surprisingly, mHFD+nLPS juvenile offspring displayed normalized spatial memory behavior and dorsal hippocampal gene expression in contrast to offspring with …
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Peripubertal Binge Ethanol, Age and Sex Modulate Microrna Expression in the Ventral and Dorsal Hippocampus of the Adolescent Rat
… 1 (SIRT1) are differentially expressed in the ventral hippocampus dependent on age and 17β-estradiol (E<sub>2</sub>). We examine whether microRNA expression, microRNA biogenesis enzymes Drosha and Dicer, and microRNA target genes BDNF and SIRT1 are altered by peripubertal binge EtOH in the …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
… GPX4) in the prefrontal cortex (PFC) and dorsal hippocampus (dHPC) of female rats subjected to the activity-based anorexia (ABA) paradigm, a model which combines a restricted feeding schedule with unlimited access to a running wheel to successfully reproduce the severe weight loss and …
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EXPOSURE TO STRESS EARLY IN LIFE AND ENHANCED RISK TO DEVELOP MOOD AND METABOLIC DISORDERS LATER IN LIFE: IDENTIFICATION OF THE COMMON PERIPHERAL AND CENTRAL MECHANISMS
… cytokine expression in the dorsal and ventral hippocampus and liver, focusing on leptin's role in inflammation. We found strong microglia activation in the dorsal hippocampus of animals vulnerable to PNS exposure, along with increased transcription of pro- inflammatory markers in the …
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LONG-LASTING MOLECULAR ALTERATIONS FOLLOWING EARLY LIFE STRESS IN RATS: ROLE OF GUT MICROBIOTA AND INFLAMMATION
… a specific inflammatory pattern in dorsal and ventral hippocampus that significantly correlated with gut microbiota composition. Overall, our findings support the notion that the negative behavioural outcomes related to early life stress exposure are associated with specific molecular …
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ROLE OF STRESS EARLY IN LIFE AND OF INFLAMMATION IN THE RISK TO DEVELOP DEPRESSION LATER IN LIFE
… I explored neuroimmune alterations in the ventral and dorsal hippocampus and prefrontal cortex of adult offspring exposed to prenatal stress, focusing on microglial activity and mitochondrial integrity. Vulnerable animals exhibited increased microglial activation, alongside mitochondrial …
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Exposure to endocrine-disrupting chemicals during periods of development: The effects of phthalates on the structure of the rat medial prefrontal cortex and hippocampus and associated cognitive behaviors
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
… and increased ERK1/2 activation in the dorsal hippocampus (DH). Proteomic analysis revealed additional region-specific changes, for example, early-postnatal ethanol exposure increased the capacity for energy production in the PFC whereas in the DH, energy-related proteins were decreased …