Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Venlafaxine"”.
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
The present work describes the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, …
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The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study
… serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet activity. However, previous evidence regarding the cardiovascular effects of these agents has been conflicting. There is a need for further …
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Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.
… serotonin polymorphisms affect the efficacy of venlafaxine and paroxetine treatment in OCD. The response in paroxetine treated patients is associated with the GG genotype of the 5-HT2A polymorphism (χ2 = 8.66, df=2, p=0.013). In venlafaxine treated patients, response is associated with the SL …
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ROLE OF CELLULAR STRESS RESPONSES IN THE PATHOPHYSIOLOGY AND TREATMENT OF PSYCHIATRIC DISORDERS
… of the chronic pharmacological treatment with venlafaxine. To this end, we took advantage of a preclinical model of stress-induced MDD, the Chronic Mild Stress (CMS), articulated in multiple designs. These included a short-term (2 weeks) and a prolonged (6 weeks) stress exposure, the latter …
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Pharmacist input into patients' self-reporting of adverse drug reactions.
… (n=2307) prescribed tramadol, fentanyl patch, venlafaxine, nefazodone, citalopram, moclobemide, gabapentin, lamotrigine and topiramate from 79 participating medical practices in Grampian during January-March 1997. The overall response rates were 44.6% (n=207) for the pilot study and 36.3% …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… older adults with depression were treated with venlafaxine (VEN) for 12 weeks. We adapted and improved a population pharmacokinetic model for VEN and its active metabolite, O-desmethylvenlafaxine (ODV). Incorporating CYP2D6 metabolizer status significantly enhanced the model’s predictive …
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Towards Precision Medicine: Characterizing and Predicting Antidepressant Remission Heterogeneity in Late-life Depression Using Genetic Data
… treated with the commonly used antidepressant, venlafaxine.First, using a candidate-gene approach, we show an association of the norepinephrine transporter gene (SLC6A2) with LLD remission (OR = 1.67 [1.13, 2.42], p = 0.009), which is a validated target of venlafaxine. In addition, we identify …
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Microwave-Mediated Hetero Diels-Alder reaction: Synthesis of biologically active compounds
… for a wide range of drugs (Prozac®, Duloxetine, Venlafaxine) with large applications in the treatment of severe diseases of nervous central system (NCS). Scheme 1 The reaction provides the formation of three new stereogenic centres (C-2; C-5; C-6). The diastereoselective outcome of these …
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Microplastics as a vector for micropollutants in aquatic environments.
… five pharmaceuticals (ibuprofen, carbamazepine, venlafaxine, fluoxetine, and ofloxacin) were selected to evaluate their interaction with microplastics. The selected micropollutants were placed in contact with microplastics in a range of pollutant combinations (in mixtures and individually). …
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Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… lamotrigine, gabapentin), three antidepressants (venlafaxine, escitalopram, trazodone), and three antipsychotics (aripiprazole, clozapine, risperidone). Chapter 1 reviews the occurrence, mechanisms of action, and environmental relevance of CNS-active pharmaceuticals, identifying key knowledge gaps …
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Pharmacotherapy for Social Anxiety Disorder and Posttraumatic Stress Disorder: New Meta-Analytic Approaches to Synthesising the Evidence
… reuptake inhibitor (SNRI) venlafaxine, monoamine oxidase inhibitors (MAOIs), reversible monoamine oxidase inhibitors (RIMAs), benzodiazepines, the antipsychotic olanzapine, and the noradrenergic and specific serotonergic antidepressant (NaSSA) atomoxetine were also effective …