Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"Venezuelan equine encephalitis"”.
-
The Host Response to Venezuelan Equine Encephalitis Virus
Viruses are currently the most common cause of encephalitis. Arboviruses in the Alphavirus genus in the family Togaviridae contain multiple viruses capable of causing human encephalitis. Of these, VEEV represents the most significant human pathogen. However, no licensed vaccines or therapeutics are …
-
Pathogenesis and transmission of Venezuelan equine encephalitis virus
Venezuelan equine encephalitis virus (VEEV) is an emerging arboviral pathogen that affects the Americas. Outbreaks can involve hundreds- of- thousands of equines and humans, spread over large geographic regions, and can last several years. The principal vector in most major coastal outbreaks is the …
-
Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus
<p>Venezuelan equine encephalitis virus (VEEV) is a New World Alphavirus that causes Venezuelan equine encephalitis (VEE), which is characterized by a febrile illness that can progress to neurological disease and death. While no major outbreaks of VEE have occurred since 1995, VEEV is a virus of …
-
Field and laboratory studies of venezuelan equine encephalitis virus ecology in Chiapas, Mexico.
The emergence of Venezuelan equine encephalitis virus in Chiapas Mexico was examined from a field approach and from a laboratory approach. This virus was not previously associated with equine disease in Mexico. The evolution of the equine virulent phenotype was thought to have resulted in a …
-
Characterization of a Low-Fidelity Live-Attenuated Vaccine for Venezuelan Equine Encephalitis Virus
… (RdRp) were tested in the live-attenuated Venezuelan equine encephalitis virus (VEEV) vaccine strain, TC-83. Next generation sequencing after passage in the presence of mutagens revealed a mutant containing 3 mutations in the RdRp, TC-83 3x, to have decreased replication fidelity, while a …
-
Characterization of the entry mechanisms utilized by the alphavirus venezuelan equine encephalitis virus to infect mosquito cells
Venezuelan equine encephalitis eirus (VEEV) is a New World alphavirus that can cause fatal encephalitis in humans. VEEV is an enveloped, positive-strand RNA virus that is transmitted by a mosquito vector. Most research on alphavirus entry was done with the Old World alphavirus Semliki Forest virus …
-
Strucutre-function studies of the venezuelan equine encephalitis virus 5'UTR promoter element and its role in attenuation of the virus
… virus replication and attenuation of \r\nVenezuelan equine encephalitis virus (VEEV) is described. VEEV is one of the \r\npathogenic members of the Alphavirus genus in the Togaviridae family. VEEV \r\ninfection causes debilitating illness complicated by neurological manifestations. The …
-
Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes disease in humans and equines eliciting both an agricultural and public health threat. In humans, the disease typically presents as a febrile illness with common signs of fever and malaise. Four to fourteen percent of …
-
Translating biomedical research data to knowledge through bioinformatics
… we investigated genomics data of several Venezuelan equine encephalitis virus mutants and showed that the replication fidelity of Tc-83 can be increased by incorporating point mutations at the RNA-dependent RNA polymerase region. These findings should accelerate the development of a new …
-
Using Altered Fidelity Viruses to Study Viral Attenuation and Population Genetics During Vertebrate Host Infection
… coupling and pathogenesis were studied using Venezuelan equine encephalitis virus (VEEV) as a model system. Fidelity mutants were generated and validated in a WT VEEV strain. These mutants were then used to infect mice. Mutants with altered fidelity demonstrated decreased lethality and …
-
Understanding the assembly of simple ssRNA virus nucleocapsids
… protein and in vitro nucleocapsid assembly; and Venezuelan Equine Encephalitis Virus (VEEV), focusing on in vivo formation of pre-viral nucleocapsid structures and briefly the subsequent post-entry nucleocapsid stage. Experimentally, it was found that H124 expressed better in E. coli expression …
-
Cross-reactivity among alphaviruses provides insight into viral emergence and novel defense strategies
… alphaviruses, such as Eastern, Western, and Venezuelan equine encephalitis viruses (EEEV, WEEV, and VEEV, respectively), present with severe encephalitis while Old World alphaviruses, such as Sindbis, chikungunya, and Mayaro viruses (SINV, CHIKV, and MAYV, respectively) present with an …
-
ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… model of acute infection with the alphavirus Venezuelan equine encephalitis virus (VEEV) and the Stat1 knockout (Stat1-/-) murine infection model with the Old World arenavirus Lassa virus. Here, I have adapted these models to study the sequelae of humans in murine models. I have replicated an …
-
Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
… that confer interferon-mediated suppression of Venezuelan equine encephalitis virus (VEEV). I show via combinatorial gene targeting that antiviral effectors - ZAP, IFIT3, and IFIT1 - together constitute the majority of interferon-mediated VEEV restriction, while comprising less than 0.5% of the …
-
Characterization of a Newly Identified Alphavirus, Eilat Virus
… analyses placed EILV basal to the western equine encephalitis antigenic complex within the main clade of mosquito-borne alphaviruses. Electron microscopy revealed that, like other alphaviruses, EILV virions are spherical, 70 nm in diameter, and they bud from the plasma membrane of infected …
Page 1 of 2