Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Venezuelan Equine Encephalitis virus"”.
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The Host Response to Venezuelan Equine Encephalitis Virus
Viruses are currently the most common cause of encephalitis. Arboviruses in the Alphavirus genus in the family Togaviridae contain multiple viruses capable of causing human encephalitis. Of these, VEEV represents the most significant human pathogen. However, no licensed vaccines or therapeutics are …
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Pathogenesis and transmission of Venezuelan equine encephalitis virus
Venezuelan equine encephalitis virus (VEEV) is an emerging arboviral pathogen that affects the Americas. Outbreaks can involve hundreds- of- thousands of equines and humans, spread over large geographic regions, and can last several years. The principal vector in most major coastal outbreaks is the …
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Examination of Antiviral Resistance in Venezuelan Equine Encephalitis Virus
<p>Venezuelan equine encephalitis virus (VEEV) is a New World Alphavirus that causes Venezuelan equine encephalitis (VEE), which is characterized by a febrile illness that can progress to neurological disease and death. While no major outbreaks of VEE have occurred since 1995, VEEV is a virus of …
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Field and laboratory studies of venezuelan equine encephalitis virus ecology in Chiapas, Mexico.
The emergence of Venezuelan equine encephalitis virus in Chiapas Mexico was examined from a field approach and from a laboratory approach. This virus was not previously associated with equine disease in Mexico. The evolution of the equine virulent phenotype was thought to have resulted in a …
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Characterization of a Low-Fidelity Live-Attenuated Vaccine for Venezuelan Equine Encephalitis Virus
During RNA virus replication, there is the potential to incorporate mutations that affect virulence or pathogenesis. For live-attenuated vaccines, this has implications for stability, as replication may result in mutations that either restore the wild-type phenotype via reversion or compensate for …
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Characterization of the entry mechanisms utilized by the alphavirus venezuelan equine encephalitis virus to infect mosquito cells
Venezuelan equine encephalitis eirus (VEEV) is a New World alphavirus that can cause fatal encephalitis in humans. VEEV is an enveloped, positive-strand RNA virus that is transmitted by a mosquito vector. Most research on alphavirus entry was done with the Old World alphavirus Semliki Forest virus …
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Strucutre-function studies of the venezuelan equine encephalitis virus 5'UTR promoter element and its role in attenuation of the virus
… \r\nUntranslated Region (5’UTR), in regulating virus replication and attenuation of \r\nVenezuelan equine encephalitis virus (VEEV) is described. VEEV is one of the \r\npathogenic members of the Alphavirus genus in the Togaviridae family. VEEV \r\ninfection causes debilitating illness …
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Utilizing Proteomic Techniques to Discover Host Protein Interactions with the E1 Glycoprotein of Venezuelan Equine Encephalitis Virus (VEEV) for Anti-Viral Discovery
Venezuelan equine encephalitis virus (VEEV) is an alphavirus that causes disease in humans and equines eliciting both an agricultural and public health threat. In humans, the disease typically presents as a febrile illness with common signs of fever and malaise. Four to fourteen percent of …
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Translating biomedical research data to knowledge through bioinformatics
… we investigated genomics data of several Venezuelan equine encephalitis virus mutants and showed that the replication fidelity of Tc-83 can be increased by incorporating point mutations at the RNA-dependent RNA polymerase region. These findings should accelerate the development of a new …
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Using Altered Fidelity Viruses to Study Viral Attenuation and Population Genetics During Vertebrate Host Infection
… hosts for the host life cycle of an arbovirus constrains its evolution. For the viral population to survive in two hosts, the ability to produce genetic diversity within the population is essential. RNA viruses contain an RNA dependent RNA polymerase (RdRp) that creates a population of …
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Understanding the assembly of simple ssRNA virus nucleocapsids
The assembly of simple ssRNA viruses from the initial interactions critical for nucleocapsid formation until the morphogenesis which occurs at each maturation stage of the virus’s “life” can entail a wide range of possibilities at every given stage. By whatever seeding event initiates the …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… to sequelae, two genera of single stranded RNA viruses are of high importance to study as models of neurological sequelae; arenaviruses and alphaviruses. Both of these viruses are important human pathogens and the cause of the long-term neurological damage, the related pathology and the …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
… many ISGs are required to restrict a particular virus, though it is theorized that numerous ISGs act in concert to achieve viral inhibition. Here, I used CRISPR-based loss-of-function screens to identify a limited set of ISGs that confer interferon-mediated suppression of Venezuelan equine …
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Characterization of a Newly Identified Alphavirus, Eilat Virus
Most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, humans, and nonhuman primates as well as mosquito species encompassing at least eight genera. The ability of alphaviruses to infect both arthropods and …
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Mechanisms and Genetic Determinants of Alphavirus Infection of Mosquito Vectors
Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne disease that has caused hundreds-of-thousands of human and equine cases. Since epizootic strains have historically been the largest public health threat, the majority of experimental studies have focused on these strains. Recently, …
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