Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Vegfa."”.
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The dissection of VEGFA stimulus-responsive regulatory and transcriptional changes in angiogenesis
… with vascular endothelial growth factor A (VEGFA) as a model system. Using data collected from multiple genome-wide assays I modeled the dynamic changes in epigenetic, transcriptional, and transcription factor binding profiles in regulation of angiogenesis, the formation of new blood …
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The role of vascular endothelial growth factor isoforms in early follicle development
… factor, vascular endothelial growth factor A (VEGFA), may influence follicle growth via regulation of angiogenesis. However, VEGFA may also influence follicular development through nonangiogenic mechanisms since its expression has been localized to nonvascular follicles and cells. Alternative …
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Contribution of the Unfolded Protein Response to VEGF Expression
… protects cancer cells, in part, by up-regulating VEGFA, which stimulates blood flow to the tumor in a process known as angiogenesis. The interplay between these two stress pathways in tumor cell survival is relatively unexplored.</p> <p>Microarray analysis of the unfolded protein response in a …
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To investigate whether VEGF and KDR polymorphisms are associated with chronic Achilles tendinopathy and self-reported measurements of tendon pain
… pain. Common DNA sequence variants within the VEGFA and KDR genes have previously been associated with musculoskeletal soft tissue injuries, including AT. The primary aim of this dissertation was to identify whether VEGF and KDR variants were associated with (i) the severity of AT, (ii) AT …
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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… in vivo. The role of the HIF target gene Vegfa was studied in a mouse model where hypoxia-induced transcription of Vegfa is abrogated (Vegfaδ/δ). HSCs could be maintained under steady-state conditions without hypoxic induction of Vegfa. In transplantation assays however, we show that when …
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Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
… an HSC in a mouse model where hypoxia-regulated Vegfa expression is abrogated. In Vegfaδ/δ mice, the HRE in the Vegfa promoter has been deleted at both alleles, thereby inhibiting HIF-binding and subsequent activation of Vegfa expression following hypoxia. We show that hypoxic regulation of Vegfa …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
… control, but capillary to fibre ratio and VEGFa mRNA was not impacted by EMPA+insulin treatment in the tibialis anterior. PECAM mRNA and VEGFa protein expression was also not impacted by EMPA+insulin treatment. EMPA has no obvious impact on the vasculature of SM in type 1 diabetic rodents.
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Whole genome sequencing approach to identifying genetic risk factors underlying anterior cruciate ligament injuries in a twin family study
… for single nucleotide polymorphisms in the VEGFA (rs699947 C/A rs1570360 G/A, rs2010963 G/C) and KDR (rs2071559 A/G, rs1870377 T/A) genes (Sweden CON: 116 ACL: 95; Poland CON: 149 ACL: 127 and Australia CON: 83 ACL: 342). Additionally, in the ACAN (rs2351491 C/T, rs1042631 T/C, rs1516797 …
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Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration
… (FGF2) and vascular endothelial growth factor A (VEGFA). These supercharged platelets aim to serve as a novel regenerative treatment for ischaemic heart disease, driving tissue repair and functional recovery in the injured heart by promoting cardiomyocyte proliferation and neovascularisation …
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The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
… like vascular endothelial growth factor (VEGFA), are critical for bone repair. However, the role that bisphosphonates and osteoblast lineage cells play in modulating these indispensable angiogenic and osteogenic factors in vivo remains undetermined.</p><p>For the first aim of the …
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Untersuchungen zur Pathobiochemie der extrazellulären Matrix bei Pseudoxanthoma elasticum (PXE)
… candidate genes, namely MMP2, MMP9, MMP14 and VEGFA, have been examined in this study. Comparison of allelic frequencies showed association of the polymorphisms c.-1575G>A, c.-1306C>T and c.-790T>G in the promoter of the MMP2 gene with PXE. Additionally, polymorphisms in the VEGFA gene could be …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… of vascular endothelial growth factor A (VEGFA). By analysing the adipose tissue of transgenic mice with elevated eosinophils both systemically and within the adipose tissue, we found a correlation between increased eosinophil number and increased VEGFA expression, increased endothelial …
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Vascular calcification as a risk factor for peripheral arterial disease and its effects on angiogenesis
… expression of key angiogenic markers Hif-1α and Vegfa mRNA levels in normoxic conditions, which coincided with an increase in their protein expression in normoxia; and reduction in hypoxia. Incubation with CM reduced cell viability and induced cell death in EC. 8-week-old OPG(-/-) mice showed …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… (TGFß, HGF, FGF2, FGF7, PDGFA, PDGFB, VEGFA y IGF2), citoquinas inflamatorias (IL6 y IL8), quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs con dos líneas celulares de cáncer de …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… come angiopoietina 1 e 2, IL-6, IL-8 e VEGFa, rispetto alle cellule giovani. In particolare, la concentrazione di VEGFa risultava aumentata di oltre quattro volte nelle cellule senescenti rispetto al controllo giovane. Abbiamo quindi indagato l’effetto paracrino del SASP derivato dai due …
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Examining Sex Differences of Adipose Endothelial Cells and the Effects of Foxo1 Deletion
… capillary density despite reduced levels of VEGFA in the adipose microenvironment. However, gonadectomy had no long-term effect on EC metabolism in culture, though direct estradiol stimulation did increase mitochondrial ATP production. One candidate contributor of sex differences is the …
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RUNX2 promueve la angiogénesis y la expresión de genes blanco con función pro-angiogénica en osteosarcoma
… RT-qPCR se observó que los genes CYR61 y VEGFA aumentaron su expresión en las líneas MG63, U2OS, HOS y G292. Por el contrario al inhibir Runx2 en SaOS, se obtuvo una baja de los niveles de CYR61 y VEGFA. Lo mismo se observó al analizar los niveles de proteína de CYR61 mediante western …
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Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI
… mice experience increased expression of Vegfa, Flt1, and Fn (Fibronectin) compared to sham-injured condition knockouts. These results demonstrate changes in expression of angiogenic factors in the absence of early differences in patterns of vessel formation, which may underlie improved …
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The genetic determinants of cardiovascular disease in patients with type 2 diabetes
… signals in the 9p21 region, ADAMTS7, ABO, and VEGFA. A meta-analysis of LEAD replicated known associations in the 9p21 region and a known locus for nicotine dependence CHRNA3. A smoking interaction analysis identified signals in ADAMTS17 that interact with smoking status to increase the risk of …
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Integrative Cancer Immunogenomic Analysis of Serial Melanoma Biopsies Reveals Correlates of Response and Resistance to Sequential Ctla-4 and Pd-1 Blockade Treatment
… by CTLA-4 and PD-1 blockade. Importantly, VEGFA was identified as a potential target of combination therapy withPD-1blockade.</p> <p>From genomic profiling (whole exome sequencing and T cell receptor sequencing), we demonstrated that a higher TCR clonality in pre-treatment biopsy was …
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