Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"Vasodilation"”.
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The Effects of Lowering Cholesterol on Vasodilation
<p>Endothelial dysfunction has been found prior to any signs of atherosclerotic plaque formation in patients with a variety of risk factors for atherosclerosis. Elevated serum cholesterol has repeatedly been associated with endothelial dysfunction as demonstrated by impaired vasoreactivity to …
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Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery
<p>Functional vasodilation in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice …
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Adenosine receptors in cutaneous thermal hyperemia and active vasodilation in humans
Mechanisms underlying the cutaneous vasodilation response to local skin heating and whole body heating in humans remain unresolved. Although nitric oxide (NO) is known to contribute to these responses, it remains unclear as to the source of NO. Adenosine receptors induce vasodilation in many human …
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The role of acute phosphate supplementation in endothelium-dependent and -independent vasodilation
Phosphate is a mineral component of the human diet that is essential for life. However, elevated blood phosphate levels are associated with cardiovascular disease and death in the general population. The mechanisms through which phosphate may be detrimental to cardiovascular health remain unclear, …
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The roles of O₂, H⁺, and K⁺ in skeletal muscle functional vasodilation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Impact of Outward Remodeling on Vasodilation in Skeletal Muscle Resistance Arteries
… The remodeling process, however, may impair vasodilation, which in turn may cause or contribute to intermittent claudication- transient pain brought on by locomotion. To stimulate the growth of collateral arteries, the femoral arteries of young, otherwise healthy mice were ligated distally to …
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The hemo-neural hypothesis : effects of vasodilation on astrocytes in mammalian neocortex
… calcium dynamics in vivo while manipulating vasodilation in vivo. Pinacidil caused a 10-20% dilation in most vessels, a degree of dilation of similar magnitude to those naturally evoked by persistent sensory stimulation (e.g. in fMRI studies). We found that increases in pial arteriole …
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The Impacts of Arterial Occlusion, Sex, and Exercise on Arteriogenesis and Functional Vasodilation
… claudication, which may be caused by impaired vasodilation. Patients demonstrate both local and systemic impairments in vasodilation, but as the collateral circulation is the primary site of resistance to the ischemic zone, impaired collateral vasodilation would have the greatest potential to …
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Effect of vasodilation on the response of muscle protein synthesis to insulin in aging
… of specific insulin-related proteins when vasodilation was increased with SNP.\r\nTherefore, this study showed that pharmacologically restoring blood flow and nutrient delivery to youthful values, did improve the response of muscle protein synthesis to insulin in older subjects. Decreases …
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Role of conceptus-induced vasodilation in controlling utero-ovarian function of ewes, cows and sows
<p>During early pregnancy, estrogens (E) and (or) prostaglandin E(,2) (PGE(,2)), secreted from the gravid uterus, may reduce the function of periarterial sympathetic vasoconstrictor nerves (PSVN), resulting in transient increases in uterine and overian blood flow (BF) previously observed on days …
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Dietary nitrate supplementation augments nitric oxide synthase-dependent and independent reflex cutaneous vasodilation in healthy humans
… would augment reflex cutaneous active vasodilation. Subjects were equipped with two microdialysis fibers on the forearm and randomly assigned as control (Ringer’s) or NOS inhibition (20mM L-NAME). Whole-body heating was achieved via water-perfused suits to raise core temperature (Tc; …
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Exercise Training Improves Cerebrovascular Oxidative Stress Regulation and Insulin Stimulated Vasodilation in Juvenile and Mature Pigs
… and cerebrovascular insulin-stimulated vasodilation in juvenile and mature pigs. Methods: Twenty juvenile (n=10F/10M; 3±1 months; mass=11±3 kg) and 17 mature (n=9F/7M; 14±1 months; mass=83±9 kg) Ossabaw miniature-pigs were divided into sedentary or exercise training groups. Pigs in the …
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Vascular Reactivity in Newly-Formed and Mature Arterialized Collateral Capillaries
… however, in the early stages of development, vasodilation is impaired. We explored the mechanism of impaired vasodilation in arterialized collateral capillaries (ACCs) and pre-existing collaterals (PECs) by evaluating endothelial-dependent vasodilation and endothelial-independent reactivity at …
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Investigating the neuroendocrine and hemodynamic responses to physical and psychological stress tasks and their effects on endothelial-dependent flow mediated vasodilation using a sustained stimulus
Few studies have compared cortisol responses to psychological and physical stress tasks with or without social evaluation. Flow-mediated dilation (FMD) with reactive hyperemia is impaired following acute stress though less is known regarding the impact of stress and cortisol on FMD with exercise …
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Local Control of Blood Flow in the Bronchial Circulation of Dogs
… BA, to determine if adenosine mediates bronchial vasodilation during airway smooth muscle contraction. DMPX blocked vasodilation to infused adenosine (0.01-0.1/vmol/min). DMPX did not reduce the vasodilation during airway smooth muscle contraction evoked by stimulating airway afferents with …
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Haemodynamic responses to heat stress and hypohydration in resting and exercising humans: Implications for the regulation of skeletal muscle blood flow
… 1 suggested that heat stress was accompanied by vasodilation in both skeletal muscle and skin vasculatures. Therefore in line with concomitant elevations in blood flow, skeletal muscle and skin vasodilation contribute to increases in leg blood flow and vascular conductance with whole body heat …
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Muscle Metaboreflex Control Of Coronary Blood Flow And Ventricular Contractility During Dynamic Exercise In Normal And Heart Failure Conditions
… in cardiac work should cause coronary metabolic vasodilation. However, little if any coronary vasodilation is observed due to concomitant sympathetically induced coronary vasoconstriction. In heart failure, cardiac output does not increase with MMA presumably due to impaired left ventricular …
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The Acute And Chronic Effects Of Resveratrol On Renal Function And Blood Pressure
… vascular resistance. The mechanism of renal vasodilation was nitric oxide dependent and through a reduction of endogenous reactive oxygen species. Resveratrol-induced renal vasodilation was not influenced by COX metabolism and vasodilatory prostanoids. We found with continuous intravenous …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… caused contraction. CGRP was a full agonist for vasodilation with an EC50 = 0.30 ± .02 pM, and relaxed the arteries via a non-nitric oxide, endothelium-independent mechanism. CGRP8-37 antagonized CGRP induced-vasodilation with low affinity (K.s = 2.71 ± 0.5 pM), suggesting that CGRP causes …
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Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology
… on the periphery, we used the neurogenic dural vasodilation (NDV) model, in which electrical stimulation of the dura mater causes reproducible vasodilation, due to calcitonic gene-related peptide (CGRP) release. In this set of experiments kainate receptor activation but not blockade was …
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