Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Vasodilatation"”.
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Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery
… field stimulation (EFS) is a uniphasic vasodilatation, mediated jointly by the neurotransmitters nitric oxide (NO) and calcitonin gene related-peptide (CGRP). 2.This study of the bovine intraocular LPCA, where a short period of EFS (10 s) was employed, demonstrated that the vasodilator …
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Comparative Effects of Various Drugs in Producing Vasodilatation in Peripheral Vascular Conditions
The therapeutic and diagnostic effectiveness of various agents in peripheral vascular conditions has presented a real demand upon investigators and clinicians, It is apparent from the literature that no single pharmacological agent has been uniformly constant in producing the desirable effect of …
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The effect of vasodilatation as obtained by lumbar sympathectomy on the growth of bones in normal young animals
The effect of changes in the circulation of blood on the metabolism of bone in general is well known to surgeons. The bones adjacent to an acute inflammatory process may share in the regional hyperaemis and undergo considerable osteoporosis. One of the most notable examples of this process has been …
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Investigation into the Vasomotor Signs and Symptoms of the Menopause
… controls, at rest and during heat induced vasodilatation. The hot flush was found to be associated with an altered cardiovascular activity and an increase in skin surface temperatures. There was a difference in the contractile activity of plasma from post-menopausal women, at rest and …
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Kardiovaskuläre Phänotypisierung von Angiotensin II AT2-Rezeptor- und adrenergen Rezeptor-"Knockout"-Mäusen
… durch Aktivitätszunahhme der P70S6-Kinase. Die Vasodilatation von Blutgefäßen wird maßgeblich durch beta1-adrenerge Rezeptoren vermittelt. Die Deletion von alpha2-adrenergen Rezeptoren (alpha2-KO) führt zur Entwicklung einer Herzinsuffizienz nach Aortenstenose. Der Mortalitätanstieg ist mit …
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The Cardiovascular Effect of GLP-1 in Humans
… effect is mediated by peripheral or coronary vasodilatation. A comprehensive assessment of the haemodynamic effects of GLP-1 in humans was made, in peripheral arteries using plethysmography, and in coronary arteries using invasive pressure and flow assessments during cardiac catherisation. I …
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Perfusionsmessungen am menschlichen Herzen mit der Magnetresonanztomographie - Quantifizierung mit der Spin-Labeling-Technik
… KHK unter Ruhe und unter Adenosin vermittelter Vasodilatation untersucht. Ein definiertes Untersuchungsprotokoll sicherte die Vergleichbarkeit der Ergebnisse, die Dauer eines Messprotokolls betrug circa 45 Minuten. Bei den Messwerten der Probanden konnte eine T1-Verkürzung unter Vasodilatation …
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Der Einfluss von diätetisch verabreichten Sojaisoflavonen auf den Homocysteinmetabolismus und die Endothelfunktion bei gesunden, postmenopausalen Frauen
… welche nichtinvasiv mittels der flussinduzierten Vasodilatation (FMD) messbar ist. Experimentelle Hyperhomocysteinämie ist mit einer reduzierten Bioverfügbarkeit von endothelialen Stickstoffmonoxid (NO) bei gleichzeitig erhöhten Spiegeln des kompetetiven Inhibitors der NO-Biosynthese …
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Microvascular inflammatory response in the skin
… in the skin. The microvascular response includes vasodilatation and plasma exudation. In the first three studies, the combined response was measured in guinea pig skin with a technique based on detection of radiolabelled protein. Transferrin was labelled in vivo by injection of 113mIn and the …
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Signal Transduction Mechanisms Mediating the Regulation of Vascular G Protein-Coupled Receptors
… in the balance between mechanisms regulating vasodilatation and vasoconstriction. The extensive loss of GRK2 expression favors an increased in vasoconstriction associated with an increase in peripheral resistance and this is likely due to the reduced Gαq/11-coupled receptor desensitization. …
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Structure and dynamics of soluble guanylyl cyclase
… many fundamental biological processes including vasodilatation. It can be allosterically activated by synthetic compound such as YC-l. Recently, the 3D structure of adenylyl cyclase (AC), which is a homologue of sGC, was determined. Using AC as template and homology modeling, the 3D structure of …
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The effects of bradykinin and angiotensin II on the thoracic aorta vasa sasorum microcirculation system
… peptides, which produce vasoconstriction and vasodilatation, respectively. They can also change the permeability of microcirculation. In the present study, we documented the effect of different concentrations of ANG II and bradykinin on the vasa vasorum of isolated rabbit throcic aorta in …
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Hämodynamische Auswirkungen synthetischer, pflanzlicher und endogener Cannabinoide im Modell der isolierten Kaninchenlunge
… über periphere CB1-Rezeptoren vermittelte Vasodilatation. Der Einfluss von Cannabinoiden auf die pulmonale Strombahn ist jedoch unklar. Am Modell einer isolierten, perfundierten und ventilierten Kaninchenlunge konnte gezeigt werden, dass die endogenen Cannabinoide Anandamid und …
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Einfluß der Atherosklerose auf den NO:cGMP Signalweg am Modell des cholesteringefütterten Kaninchen
… zelluläre Signalwege, die im Gesunden eine Vasodilatation hervorrufen können, sind in atherosklerotischen Gefäßen gestört, so auch der NO:cGMP-Signalweg. Der Einfluß der Atherosklerose auf den NO-abhängigen Teil des Signalwegs, also NO-Produktion und -Abbau, sowie Diffusion von NO zu den …
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Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model
… however, improved rhythm stability and coronary vasodilatation were still present. In addition adenosine alone was able to induce fast electromechanical arrest in the isolated rat heart. However, failure of even high concentrations of adenosine to limit ventricular fibrillation in the baboon …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… mainly situated on endothelial cells, mediating vasodilatation. The endothelin system is involved in several pathophysiological conditions, such as atherosclerosis and ischemic stroke. Previous studies have shown an upregulation of contractile ETB receptors in the ipsilateral middle cerebral …
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The role of reactive oxygen species in the endothelium derived hyperpolarising factor response
… oxide (NO) and prostacyclin (PGI2) -independent vasodilatation pathway that is the dominant relaxation mechanism in the microcirculation, and has been shown to require IKCa and SKCa channel activation and also functional myoendothelial gap junctions. Reactive oxygen species (ROS) have been …
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Audit of acute limb ischaemia in a paediatric intensive care unit
… to increased blood flow to the affected limb via vasodilatation of collateral vessels, with an added advantage of reducing ischemic pain. The improved blood flow is postulated to avoid and/or minimise the amount of tissue loss. Pharmacological sympathectomies may, thus, have a role to play in th e …
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
… an increase in cardiac contractility and vasodilatation, similar to apelin. These effects were achieved without receptor desensitisation, supporting the remarkable G protein bias observed in vitro. Furthermore, it was disease-modifying in vitro in an endothelial cell apoptosis assay but …
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Cerebral Microcirculatory Effects of Maturation
… a role for K<sub>ATP </sub>channels in hypoxic vasodilatation, which is larger, yet, less sensitive in newborns than in adults. Accordingly, our studies also define a glyburide-resistant but depolarization-sensitive relaxant component of the response to hypoxia, that appears to represent …
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