Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Vasculitis"”.
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Pharmacological Management of Vasculitis
Vasculitis, also reffered to as systemic vasculitis or vasculitis syndrome and is a general term for diseases in which inflammation occurs in blood vessels themselves. Here, pharmacological management for each vasculitis are described.
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Kinin System Activation in Vasculitis
… liberation of inflammatory cytokines and pain. Vasculitis is an autoimmune systemic inflammatory disease, characterized by leukocyte inflammation in and around vessel walls leading to perturbed vessel patency and tissue damage. Many different organs may be afflicted but most commonly the kidney, …
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Improving patient outcomes in systemic vasculitis
… The underlying aetiology for most forms of vasculitis is unknown. The resulting blockage of blood flow causes tissue ischaemia which can result in organ damage or death. Making an early diagnosis is difficult. Treatment is usually toxic, and morbidity and mortality from vasculitis is high. …
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B cell therapy in ANCA-associated vasculitis
… cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with a UK prevalence of 250 per million. The immunopathogenesis includes neutrophil activation by B cell-derived ANCAs, activation of the alternative complement pathway, and dysregulated T cell responses …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… cytoplasmic antibody (ANCA) associated vasculitis (AAV) is an autoimmune disease characterised by inflammation of small blood vessels that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and proteinase …
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Endothelial injury and repair in vasculitis of the young
… responses in children with primary systemic vasculitis. It focuses in particular on circulating endothelial cells, cellular microparticles, growth factors involved in angiogenesis/vasculogenesis and endothelial progenitor cells. Circulating endothelial cells are mature endothelial cells which …
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Studies on the Epidemiology and Outcome of Primary Systemic Vasculitis
… on the date of p.p., was measured using the Vasculitis Damage Index (VDI), for all the 86 patients from Paper I. Organ damage was very common in our patients, the medium VDI score was 3 and only 9% had not been assigned any item of damage. The most common type of damage was cardiovascular, …
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Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis
ANCA-Associated Systemic Vasculitis (AASV) is characterized by leukocytoclasis- dying neutrophils surrounding small blood vessels. Previous studies have shown increased plasma PR3 and increased proportion of neutrophils expressing plasma membrane-associated PR3 (mPR3+). Neutrophils were isolated by …
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The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
… cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a multi-systemic autoimmune disorder with evidence of circulating pathogenic ANCA. There are two main antigenic targets: proteinase 3 (PR3) and myeloperoxidase (MPO). Previous genome-wide association studies (GWAS) have provided …
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The development of a humanised mouse model of ANCA associated vasculitis
… and are associated with a systemic autoimmune vasculitis, in which a pauci-immune crescentic glomerulonephritis is common. The in vivo study of ANCA pathogenesis is severely limited, both by the lack of a robust anti-PR3 IgG induced disease model, and by the differences found between human and …
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Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis
Primary systemic vasculitis is associated with a high mortality if left untreated and it is essential to make the diagnosis before permanent organ damage has occurred. In this thesis the diagnostic and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitis …
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The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
… cytoplasmic antibody (ANCA) associated vasculitis is a systemic disease i affects the kidneys, lungs, and other tissues. ANCA were first described in patients i focal necrotising glomerulonephritis in 1982, with myeloperoxidase )) and proteinase 3 (PR3) subsequently shown to be the …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… tissues of the autoimmune disorders myositis and vasculitis, two autoimmune disorders characterised by a wide range of autoantibodies which have been implicated in the pathological mechanisms of these diseases. This study aimed to test the hypothesis that infiltrating B cells within the target …
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Global and regional central nervous system sequelae of anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a devastating systemic condition affecting about 300 people per million annually. While the systemic consequences of this condition are well documented, its central nervous system sequelae are poorly understood. We performed a …
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What are the informational needs of patients with ANCA Associated Vasculitis? a Mixed Methods Study
… then a questionnaire surveying the membership of Vasculitis UK (VUK) and the Vasculitis Clinical Research Consortium (VCRC). Results: Emergent themes from the first phase were: reaction to diagnosis, need for information on disease management and access to knowledgeable practitioners. There were …
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Heterogeneity of injury in vasculitis: influence of anti neutrophil cytoplasm antibody IgG subclass and endothelial susceptibility.
… study examined IgG subclass in ANCA associated vasculitis and glomerular endothelial cell (GEC) phenotype predisposes to injury. Using the flow model, interaction of neutrophils with normal immunoglobulin subclasses was compared to interaction with subclasses of ANCA IgG. Neutrophils were …
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Immunological responses following surgery in ulcerative colitis
… immunological similarities with systemic vasculitis. Perhaps, UC represents a gut limited vasculitis. Persistance of ANCA, AECA, anti-EPI and antitropomyosin antibodies in the sera, several years following total colectomy, suggests that immunological mechanisms are not halted, by total …
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MPhil in pulmonary haemorrhage in children in Cape Town
… Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one …
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Entry of feline infectious peritonitis virus in blood monocytes
… viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the …
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