Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 533 for “"Vasculature"”.
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Targeting Nanoparticles to Tumor Vasculature
Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use escape mechanisms against chemotherapeutic agents as frequently as tumor cells …
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Multimodality Imaging of Tumor Vasculature and Metabolism
… America. A number of abnormal features in tumor vasculature and metabolism have been identified as imaging biomarkers to detect tumor boundary, provide physiological information, predict treatment response and guide surgeries. In chapter 2, longitudinal MRI was applied to monitor the initiation …
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The effect of cutaneous vasculature on skin pigmentation
ABSTARCT i TABLE OF CONTENTS ii LIST OF FIGURES iv LIST OF TABLES vii I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. Cell cultures and treatment 3 B. Co-culture using transwell system 4 C. Preparation of the bEnd.3/HUVECs conditioned medium 4 D. Ultraviolet (UV) irradiation of endothelial cells 5 …
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Spatiotemporal controlled delivery of nanoparticles to injured vasculature
… delivery. Targeting ligands that bind injured vasculature were discovered and optimized by screening an M13 bacteriophage library (109 independent clones) against collagen IV, the major component of the basement membrane. Relative binding affinities using ELISA identified the lead targeting …
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Mapping The Human Vasculature By In Vivo Phage Display
… pattern on the surface of tumor-associated vasculature. Collectively, these data support a functional role for giantin on the surface of HCC tumor endothelium that could potentially be exploited for delivery of imaging and therapeutic agents. Ultimately, this work serves as the foundation of …
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A Morphological and Hemodynamic Analysis of Skeletal Muscle Vasculature
… develop analysis tools to assess skeletal muscle vasculature on a network level. In conjunction with this goal, this project also assessed whether the gracillis anterior muscle of a mouse was sufficiently thin to perform a comprehensive morphological analysis, and whether the data generated from …
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Imaging The Vasculature With Susceptibility Weighted Imaging: Applications And Analysis
… properties of venous blood in the peripheral vasculature during periods of immobility were examined. SWI images were collected for nine subjects at two time points: within ten minutes of entering the magnet and after 40 minutes spent stationary in the magnet. Changes in the phase and in the …
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High Resolution Maps of the Vasculature of An Entire Organ
… by the superficial venation of the hands and the vasculature of the retinae. Mathematically, we may state that there is no conserved topology in vascular networks. Efficiency demands that these networks be regular on a statistical level and perhaps optimal. We have taken the first steps towards …
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Studies of the renin angiotensin system in the human vasculature
… conversion of AI to AII can occur within the vasculature. This conversion was resistant to inhibition of ACE with enalaprilat in human tissue. In contrast, AI responses in rabbit arteries were almost completely inhibited by enalaprilat. Further investigation demonstrated that the combination …
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Enhanced Vasculature Imaging of the Retina Using Optical Coherence Tomography
… behavior and response of the retinal tissue and vasculature, earlier treatment for disease may be prescribed, thus preserving vision for the patient. </p><p>Within the last decade, significant technological advances in OCT systems have enabled high-speed and high sensitivity image acquisition …
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Comprehensive geometric modeling of human cerebral vasculature for quantitative vascular analysis
… and structured geometric model of human cerebral vasculature for quantitative anatomical analysis. We first proposed a general and structured geometric representation of the interconnected vascular network as a framework. We then described an image processing pipeline for the segmentation of …
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4D Control of Tissue Development and Blood Vasculature using Photo-mediated Chemistries
… motivated to explore of the interactions between vasculature and parenchyma. In aim 1, a novel photodegradation-based vascular fabrication methodology is developed, wherein PEG hydrogels are modified with a photodegradable ortho-nitrobenzyl moiety. Combining this novel material with a programmable …
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Morphological, functional, and therapeutic aspects of brain tumor vasculature: an experimental study
Contains fulltext : 145677.pdf (Publisher’s version ) (Open Access)
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The role of the vasculature in iron allocation and sensing in plants
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Most of the human population rely on plant-based products as the major dietary source for nutrients including iron (Fe). In terms of food security, and besides struggling to solve the problem of producing enough food …
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Characterisation of a Novel GABA Signalling System in the Human Cerebral Vasculature
… in the rodent brain and in the human peripheral vasculature, but the receptor systems and cellular machinery underlying this regulation have not been characterised. And as yet, there have been no attempts to confirm the existence of this putative vascular GABA signalling system in the human …
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Tumor vasculature and microenvironment during progression and treatment : insights from optical microscopy
In addition to cancer cells, solid tumors consist of a variety of cell types and tissues defining a complex microenvironment that influences disease progression and response to therapy. To fully characterize and probe the tumor microenvironment, new tools are needed to quantitatively assess …
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
In this thesis, we developed a microfluidic-based platform for the generation of physiologically relevant 3D lymphatic capillaries. This tissue engineering platform allowed us to probe the vascularization dynamics of lymphatic endothelial cells under a highly controlled microenvironment and isolate …
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Fractal vasculature and vascular network growth modeling in normal and tumor tissue
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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