Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Vascularization"”.
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
… templating towards organ-scale engineered tissue vascularization. First, we address biocompatibility and scalability challenges by embedding microparticles within sacrificial templates to enable controlled, rapid template evacuation while preserving cellular viability in the tissue parenchyma. We …
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Analysis of mammalian tumor vascularization in the development of a therapy to prevent metastasis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1986.
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Tear Film VEGF in Dogs with Vascularizing Corneal Disease
… of unilaterally diseased dogs, and normal dogs. Vascularization scores were assigned to diseased eyes and tear film VEGF concentration was assayed as above. Mean tear film VEGF concentration of diseased eyes did not differ from control eyes, and was not correlated with disease process, extent of …
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Rapid formation of cell-mediated microvascular networks in collagen, fibrin, and puramatrix provisional matrices
… To address these challenges, we developed a vascularization model in which human endothelial colony-forming cells (ECFCs) and mesenchymal progenitor cells (MPCs), coinjected with a solubilized extracellular matrix (ECM), rapidly form perfused blood vessel networks in mice. This dissertation …
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Barbiturate treatment in experimental transient focal cerebral ischaemia
… a cerebral vessel occlusion followed by re-vascularization, had not been specifically investigated with barbiturate treatment. Cerebral infarction is progressive and evolves over hours, proceeding from ischaemia and functional loss to cell death. Sundt et al (1969), Crowell et al (1970), …
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Development of an endometrial inspired biomaterial
… of how native vascular processes translate to vascularization in an in vitro environment and to develop new techniques to efficiently pre-vascularize biomaterials. The intent of this model is to incorporate biological cues inspired by a physiological vascularization process that occurs within …
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Overcoming Diffusion Limitations in Encapsulated Cell Therapy for Type 1 Diabetes
… we analyze the potential benefit of increasing vascularization at the surface of the alginate capsule. Although the islet must remain avascular to be protected from the immune system, the diffusion analysis illustrates that vascularization at the capsule surface could increase oxygen delivery. …
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THE EFFECT OF SDF1α ON SKELETAL MUSCLE REGENERATION AFTER COMPARTMENT SYNDROME INJURY
… and has been suggested to enhance tissue vascularization. In this preliminary study, we tested the effects of SDF1α treatment on the recovery of skeletal muscle function and tissue morphology in a rat compartment syndrome (CS) injury model. We have previously demonstrated that this model …
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Engineered, functional, human microvasculature in a perfusable fluidic device
… containing pancreatic islets, respectively. Vascularization, in our system, was achieved by encapsulating endothelial cells in a 3D fibrin matrix and relying on their inherent ability to collectively self-assemble into a functional vasculature - as they do during embryonic development. To …
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… engineering platform allowed us to probe the vascularization dynamics of lymphatic endothelial cells under a highly controlled microenvironment and isolate the effects of biochemical and biophysical inputs. Under this precise control over local extracellular factors, we studied the angiogenic …
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
… bacterial factors that promote granuloma vascularization. Using Mycobacterium marinum transposon mutants in a zebrafish infection model, we revealed the enzyme Proximal Cyclopropane Synthase of alpha-Mycolates (PcaA) as an important bacterial determinant of host angiogenesis. We found that …
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The use of ultrasound in the prediction of endometrial cancer in women with postmenopausal bleeding
… thickness, Vascularity index (reflecting the vascularization of the endometrium when using power Doppler ultrasound), age, and use of hormone replacement therapy. The endometrial volume as measured by three-dimensional (3D) ultrasound was larger and the 3D power Doppler flow indices …
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Hydrogel cell encapsulation for tissue engineering
… of control over tissue architecture as well as vascularization continue to limit the efficacy of engineered constructs. This thesis describes work aimed at tackling these two problems. First, two techniques for generating size- and shape-controlled cell-laden hydrogels are described in the …
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The role of vascular endothelial growth factor isoforms in early follicle development
Since vascularization of the theca layer increases as follicles progress in size through preantral and antral stages, the principal angiogenic factor, vascular endothelial growth factor A (VEGFA), may influence follicle growth via regulation of angiogenesis. However, VEGFA may also influence …
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Probing the role of cell-cell interactions in hepatic ensembles
… (1) cell sourcing, (2) graft scale-up, and (3) vascularization, all of which contribute to therapeutic performance. The performance of an implantable graft is a function of the underlying cell-cell and cell-matrix interactions. These grafts typically consist of a multicellular ensemble in which …
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Engineering micro-perfusable scaffolds for MesoPhysiological Systems using projection Micro-StereoLithography
… community driving major efforts towards in vitro vascularization methods. A major obstacle to the development of these MPS was the micrometric scale of the human cells forming the building block of any biological system.
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Sacrificial polymers for rapid manufacturing of bioinspired vascular materials
… reconfigurability applications. However, this vascularization method is a two-step energy-intensive process that requires sustained external heating to first polymerize the thermoset matrix, and then to depolymerize the embedded sacrificial PLA templates into volatile products (ca. 200 °C for …
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
Tumor vascularization is an important control point in cancer progression and its inhibition is a promising approach to cancer therapy. Stromal-derived factor-1 alpha (SDF-1 alpha or CXCL12) is a chemoattractant for lymphocytes, hematopoietic progenitor cells, and vascular endothelial cells. SDF-1 …
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The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
… in a chicken embryo tumour model resulted in vascularization of MCF-7 tumours; a phenotype that was partially maintained following expression of MT1-MMP CD variants. These results suggest that the CD regulates MT1-MMP localization in a manner required for cell survival, but is dispensable for …
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INDUCIBLE CELL EXPRESSION OF MMP1A FOR TUNABLE DEGRADATION OF BIOMIMETIC SCAFFOLDS
Therapeutic vascularization remains a challenge in the field of tissue engineering. Designing tissues for long-term success involves finding methods to incorporate functional vascular networks capable of providing nutrients and oxygen and removing wastes from surrounding cells. Recent advances have …
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