Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Vascularisation"”.
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… process of induced blood vessel sprouting and vascularisation are essential for the growth and progression of solid tumours. Recruitment of blood vessels is also an important step of the metastatic cascade that enables development of macrometastasis and growth to secondary tumours. Thus, …
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Étude des liens entre les mesures quantitatives de la vascularisation cérébrale, les fonctions cognitives et la neuropathologie dans la maladie d’Alzheimer
Introduction: With the aging of the world population, it is estimated that approximately 78 million people worldwide will be affected by a major neurocognitive disorder (TNC) in 2030. However, the etiology of Alzheimer's disease (AD), the most common form of major TNC, remains unclear. Given the …
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Clinical utility of 3D power doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies
… of baseline maternal characteristics, placental vascularisation indices, uterine artery Doppler and maternal serum biomarkers (Pregnancy Associated Plasma Protein-A (PAPP-A), Placental like Growth Factor (PlGF), soluble Fms-like tyrosine kinase (sFLt-1) and soluble Endoglin (sEng)) measured in …
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Drug eluting electrospun scaffolds for tissue regeneration
… insufficient porosity, thrombogenicity, lack of vascularisation and/or excessive inflammation. This study aimed at increasing structural porosity and incorporating/delivering anti-thrombotic/angiogenic (heparin) and anti-inflammatory (dexamethasone) agents. Porosity enhancement techniques were …
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Tierexperimentelle Untersuchungen zur Adipogenese in Gel-Trägern als Weichgewebsersatz
… gel-based carriers two different types of vascularisation (axial and randomised) were created. Axial vascularisation was produced by transposition of femoral artery and vein into the chamber. Randomised vascularisation was achieved by direct contact to subcutaneous tissue. Neotisssue …
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Die Gefäßarchitektur der Bauchwand und ihre Stellung in der Plastischen Chirurgie : eine anatomische Untersuchung
… / or necrosis of the umbilicus, due to decreased vascularisation as a result of plastic surgical interventions as in abdominoplasty or abdominal flap surgery e.g. TRAM-flaps, VRAM-flaps, DIEP-flaps and SIEA-flaps are frequent. Aim of this study is to define territories of the abdominal wall which …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… the highest levels of cancer cell proliferation, vascularisation, and implant attachment were seen in WT and NC HOS-143B tumours compared to ATG7 KO HOS-143B tumours. According to immunohistochemistry, levels of the angiogenesis marker-VEGFR2 in WT and NC HOS-143B cells was significantly greater …
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Development of the chick chorioallantoic membrane (CAM) model to assess tumour growth and drug response in osteosarcoma and bladder cancer
… by basophilic nuclei, acidophilic cytoplasm and vascularisation. In contrast, BC cell lines demonstrated slower proliferation and localised invasion, likely due to the bone scaffold not being their native environment but only a site of metastasis. In STAT3-IN-1 treated HOS-143B samples, …
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Reproduction management in female Lynx (Lynx lynx)
… and parturition, followed by decreased luteal vascularisation and a drop in serum P4. The influence of artificial prostaglandins resulted in a significant reduction of the luteal vascularisation, as well as a drop in P4. Similarly to the natural cycle, a structural regression of the luteal …
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The Influence of Structure and Surface Biochemistry on Cell Function and Angiogenesis in Collagen Scaffolds
… but until now very little work has focused on vascularisation of these structures. The aim of the work described in this thesis was to develop in vitro cell culture models, to study the effects of structural features and surface chemistry properties on the formation of microvessels. Firstly, …
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Endostale Gefäßversorgung der Diaphyse der humanen Tibia : Gefäßarchitektur und Verlauf der Arteria nutricia tibiae mit Bezug auf deren Beeinträchtigung nach aufgebohrter und unaufgebohrter Marknagelung
… Fracture healing complications due to limited vascularisation after reamed and unreamed intramedullary nailing, the intraosseal course of the human arteria nutricia tibiae and its impairment by the intramedullary nailing needs an actual analysis. Method: The arteria nutricia of 26 corps tibiae …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… rate, immune cell infiltration, hypoxia, or vascularisation. Growing cells outside the primary tumour as primary cell lines and then implanting them orthotopically into rodent brains did not change their metabolic phenotype. In addition, modulation of the microenvironment *in vitro* …
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HIF-1alpha role in oxygen-dependent radio- and chemosensitivity
… of various genes associated with growth, vascularisation and metabolism. However whether HIF-1α plays a causal role in promoting hypoxic resistance to antitumour therapies remains unclear. In this study we used pharmacological and genetic methods to investigate the HIF-1α contribution to …
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Conception et biocompatibilité de composites biodégradables pour le remplacement et la reconstruction osseuse
… de la colonisation du matériau et de la néo-vascularisation, permettant de réformer la structure tissulaire manquante ou endommagée. En somme, l’élaboration de ces nouveaux matériaux a pour but d’améliorer la qualité de vie des gens ayant besoin de transplantation d’organes ou de réparation …
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An Investigation of the Role of Bacillus oleronius in the Pathogenesis of Rosacea
… of the eyelids (blepharitis), increased vascularisation of the ocular surface and in severe cases inflammation of the cornea (keratitis) can develop leading to sterile ulcers and visual impairment. Individuals with rosacea often have an elevated presence of Demodex mites in their skin …
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Fabrication and Optimisation of Collagen Scaffolds for Muscle Cell-Supported Angiogenesis
Vascularisation is essential for the success of tissue engineered scaffolds, facilitating appropriate oxygen, nutrient, and waste transport in structures larger than diffusion transport can achieve. Combining insights and priorities from the fields of tissue engineering and cultivated meat, this …
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Early vascular access in the critical adult : intraosseous and intravenous approaches.
… as the PIV route as an easily accessible form of vascularisation without compromising patient treatment. The literature search yielded over one thousand articles. Articles were included into the appraisal if they were studying PIV or IO access on adult human patients or animal models during an …
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Mapping Human Liver Development using Single-Cell Transcriptomics to Reveal Pathways Directing Stem Cell Fates
… in liver extracellular matrix formation and vascularisation in support of hepatoblast growth and differentiation during development. We utilised this information to derive bipotential hepatoblast organoids and used this novel model system to validate the importance of key signalling pathways …
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Insights into the palaeobiology of sauropodomorph dinosaurs through an analysis of their bone histology
… indet. differ primarily in the degree of vascularisation around LAGs and secondary reconstruction. The number of growth marks varied between two to three in the fragmented Sauropodiforme indet., five to six in Melanorosaurus and Plateosauravus and up to ten in Lessemsauridae indet. LAGs in …
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Feto-placental vascular structure and function: comparison of within and between species variations
… differences in human and rodent fetoplacental vascularisation. This thesis is motivated by a need to understand species differences, as despite promising therapies for pregnancy complications in animal models, clinical effectiveness is limited due to differences in placental structure and …
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