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Showing 1 to 20 of 30 for “"Vascular smooth muscle cells (VSMCs)"”.
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Role of ET-1 and its receptors in the impairment of vascular functions in the cardiomyopathic hamster
… the difference depends on the presence of the vascular endothelium. We also wanted to verify if the contribution of ET-1 receptors (ET[indice inférieur A] and/or ET[indice inférieur B]) in the vascular endothelium and vascular smooth muscle cells (VSMCs) undergoes changes during the development …
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PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, ATHEROSCLEROSIS AND EXTRACELLULAR VESICLES ¿ EXPERIMENTAL AND CLINICAL EVIDENCE
Vascular smooth muscle cells (VSMCs) are key participants in both early- and late-stage atherosclerosis and influence neighbouring cells possibly by means of bioactive molecules, some of which are packed into extracellular vesicles (EVs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is …
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Stiffness of vascular smooth muscle cells from aged primates measured using reconstituted tissue model
… potential contribution from stiffening of the vascular smooth muscle cells (VSMCs) with age. VSMCs previously obtained from young and old monkeys (macaca fascicularis) were seeded into a collagen gel to form a reconstituted tissue. The aim of this study was to quantitatively characterize the …
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Effects of hypertension and aging on vascular smooth muscle cell contribution to reconstituted aortic tissue stiffness
… a reconstituted aortic tissue model (composed of vascular smooth muscle cells (VSMCs) in a collagen matrix) was developed. VSMCs isolated from thoracic aortic samples of 5-week and 18-week old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were passaged four …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… Mitochondrial function in atherosclerosis and vascular smooth muscle cells Johannes Reinhold Atherosclerosis is the leading cause of death in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient to …
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IN-VITRO VASCULARIZED TISSUE EQUIVALENTS FROM HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELLS
Vascularization is one of the key elements towards success in tissue engineering and cell therapy. One of the major obstacles challenging successful tissue engineering is the formation of functional vascular networks. Secondly, these applications require scalable production of homogeneous …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
Vascular smooth muscle cells (VSMCs) are phenotypically plastic. Thus, while the VSMCs in healthy blood vessels are ‘contractile’ and control vascular tone, these cells can increase their synthetic, migratory and proliferative capacities in response to vessel injury. While largely adaptive, actions …
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Applications of Mass Spectrometry to Analysis of Prodiginines, Bioactivated Methylenedianiline Intermediates, and Hypoxia Induced Changes in the Zebrafish Skeletal Muscle Proteome
… of 4, 4'-methylenedianiline (DAPM) from rat vascular smooth muscle cells (VSMCs) and bile. In our study, several DAPM metabolites were detected and characterized in detail by liquid chromatography-electrospray tandem mass spectrometry. The structural assignments of these metabolites from …
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Angiotensin II-induced Apoptosis in Vascular Smooth Muscle Cells: Differential Effects in Human Saphenous Vein and Human Internal Mammary Artery
… serves as a viable treatment for arterial vascular occlusions. However, the likelihood for developing restenosis following coronary artery bypass grafting surgery remains a major threat. Subsequently, assessing the physiological differences of conduit bypass vessels has become a crucial …
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Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
… cytokine implicated in atherogenesis and other vascular diseases. However, control of its activation and release has been predominantly studied in macrophages, with scant data on whether vascular smooth muscle cells (VSMCs) can release IL-1β. I investigated the expression, activation and release …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
The phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile /differentiated state to a synthetic/ proliferative state is a hallmark of many cardiovascular diseases, driven in part by extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in …
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THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… Patients with CKD have an increased cardiovascular risk, mostly due to vascular calcification (VC). By now, it’s quite clear how, in vitro and in vivo, vascular smooth muscle cells (VSMCs) actively participate to VC. In contrast to the wide studies on VSMCs, the role of endothelial cells …
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The Convergence of Accelerated and Physiological Vascular Ageing: A Multi-Omic Analysis of 2D and 3D in vitro models of Progeria
… of ageing contribute heavily to onset of vascular disease with age. With the average age of global populations increasing, the associated rise in vascular diseases presents a huge challenge. A key obstacle in vascular gerontology research is a lack of suitable in vitro human models which …
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Investigating the Mechanisms Underlying the Heterogeneous VSMC Contribution to Vascular Disease
In healthy blood vessels, vascular smooth muscle cells (VSMCs) exist in a contractile, quiescent state but upon vascular insult can switch phenotype to activate proliferation, migration and remodelling of the extracellular matrix. Phenotypically switched VSMCs contribute most cells within …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… factor which shows increased activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
Introduction: Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and display phenotypic plasticity that influences both plaque growth and stability. The fibrous cap, a stabilising feature of plaques, contains an abundance of VSMC-derived cells. However, the cellular …
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Synthesis, evaluation, and applications of hydrogen sulfide-releasing supramolecular materials
… hours and inhibited the proliferation of human vascular smooth muscle cells (VSMCs) significantly better than fast-releasing NaSH salts. This study shows a promising application of supramolecular H2S-releasing materials over widely used sulfide salts. The macroscopic properties of peptide …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… tamoxifen in both adventitial fibroblasts and in vascular smooth muscle cells (VSMCs). Interestingly, I observed that deletion of RelA from aortic VSMCs and fibroblasts, using Col1a2-CreERT mice containing RelA-flox alleles, protects from Ang II mediated AAA formation. Furthermore, aortic-RelA …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
… aneurysms (AAs) presents a significant cardiovascular risk, with limited treatment options. Our laboratory examined wild-type (WT) and BCL11B knockout (BSMKO) mice treated with Angiotensin II (AngII) for a period of 7 days. The BSMKO mice given AngII exhibited aneurysm formation, while the WT …
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Elucidating the structure-function relationship of the cell-type specific splicing regulator, RBPMS
… alternative splicing programme in differentiated vascular smooth muscle cells (VSMCs). RBPMS has an N-terminal RNA recognition motif (RRM) that mediates both RNA binding and dimerization, allowing binding to pairs of trinucleotide CAC motifs. The C-terminal tail is predicted to be unstructured, …
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