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Showing 1 to 20 of 88 for “"Vascular smooth muscle cells"”.
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
… Mitochondrial function in atherosclerosis and vascular smooth muscle cells Johannes Reinhold Atherosclerosis is the leading cause of death in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient to …
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Stiffness of vascular smooth muscle cells from aged primates measured using reconstituted tissue model
… potential contribution from stiffening of the vascular smooth muscle cells (VSMCs) with age. VSMCs previously obtained from young and old monkeys (macaca fascicularis) were seeded into a collagen gel to form a reconstituted tissue. The aim of this study was to quantitatively characterize the …
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Mechanical Strain-Mediated Syndecan Regulation and Its Effects on Adhesion of Vascular Smooth Muscle Cells
An injured vascular system has a substantial impact on an individuals overall health, and an understanding of the mechanisms that underlie blood vessel pathophysiology is required for the development of rational and effective treatment strategies. The phenotypic modulation of smooth muscle cells …
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Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells
… cytokine implicated in atherogenesis and other vascular diseases. However, control of its activation and release has been predominantly studied in macrophages, with scant data on whether vascular smooth muscle cells (VSMCs) can release IL-1β. I investigated the expression, activation and release …
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IN-VITRO VASCULARIZED TISSUE EQUIVALENTS FROM HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELLS
Vascularization is one of the key elements towards success in tissue engineering and cell therapy. One of the major obstacles challenging successful tissue engineering is the formation of functional vascular networks. Secondly, these applications require scalable production of homogeneous …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
Vascular smooth muscle cells (VSMCs) are phenotypically plastic. Thus, while the VSMCs in healthy blood vessels are ‘contractile’ and control vascular tone, these cells can increase their synthetic, migratory and proliferative capacities in response to vessel injury. While largely adaptive, actions …
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The Role of Ca²⁺/CaM-Stimulated Phosphodiesterase 1C in Vascular Smooth Muscle cells of the Synthetic/Activated Phenotype
… levels of these second messengers. Many cardiovascular diseases are associated with a change in vascular smooth muscle cell (VSMC) phenotype, resulting in a hyperproliferative cell devoid of contractile properties. This cell has been defined as “synthetic/activated” and differs from the normal …
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Angiotensin II-induced Apoptosis in Vascular Smooth Muscle Cells: Differential Effects in Human Saphenous Vein and Human Internal Mammary Artery
… serves as a viable treatment for arterial vascular occlusions. However, the likelihood for developing restenosis following coronary artery bypass grafting surgery remains a major threat. Subsequently, assessing the physiological differences of conduit bypass vessels has become a crucial …
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The role of altered cyclic strain patterns on proliferation and apoptosis of vascular smooth muscle cells - implications for in-stent restenosis
… of the arterial wall predominantly due to vascular smooth muscle cells (SMC) migration from the media to the intima and subsequent SMC proliferation. A stent procedure dramatically alters the level of strains and stresses in the coronary artery and hence the mechanical environment of the …
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Cyclic stretch-mediated release of vascular endothelial growth factor by vascular smooth muscle cells : a role in improved vascular graft patency
… show the upregulation of VEGF in contractile cells subjected to cyclic stretch and the profound effects which cyclic stretch has been shown to have on the release of other cytokines by SMC, this study investigates the role which cyclic stretch might play in VEGF expression by SMC in a …
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Delta Like Ligand 4 Is A Critical Regulator of Bone Marrow Cell Differentiation Into Pericytes/Vascular Smooth Muscle Cells and Is Essential For The Vasculogenesis That Supports The Growth of Ewing’S Sarcoma
… the process by which bone marrow-derived cells are recruited to the tumor and organized to form a blood vessel network de novo, is essential for the growth of Ewing’s sarcoma. We further demonstrated that these bone marrow cells differentiate into pericytes/vascular smooth muscle …
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Examining the roles of resident non-myogenic mesenchymal cell populations in skeletal muscle development and injury
<p>The success of muscle development and regeneration requires cooperation from both myogenic and their supportive niche cells. The muscular niche is complex. At the cellular level it is composed of a broad number of cell types including: endothelial vessels, nerve and nerve-supporting cells, …
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Nkx3.2 regulates zebrafish vascular stabilization through recruitment of mural cells
Vascular stabilization is the process during vascular development where the immature endothelial cell tube gains structural support through the recruitment and adhesion of perivascular mural cells; pericytes and vascular smooth muscle cells (vSMC). When vessels are not well supported by mural cells …
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Role of ET-1 and its receptors in the impairment of vascular functions in the cardiomyopathic hamster
… the difference depends on the presence of the vascular endothelium. We also wanted to verify if the contribution of ET-1 receptors (ET[indice inférieur A] and/or ET[indice inférieur B]) in the vascular endothelium and vascular smooth muscle cells (VSMCs) undergoes changes during the development …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
Coronary vascular smooth muscle cells (cVSMC) and cardiac fibroblasts are essential for coronary artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into …
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