Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Vascular repair"”.
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Prolylcarboxypeptidase protects from vascular dysfunction and promotes vascular repair
… The following studies characterize the vascular phenotype of the PRCP-deficient (PRCPgt/gt) mouse. Compared to wildtype animals, PRCPgt/gt are hypertensive and demonstrate faster times to induced arterial thrombotic occlusion. PRCPgt/gt have increased levels of vascular reactive oxygen …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of ARDS pathogenesis, particularly in the context of SARS-CoV-2 infection. This thesis investigates the role of microtubule-associated End Binding Protein 3 (EB3) in regulating pathological calcium …
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Vasogenic bloodborne progenitors and diabetes
… in particular, those which affect the vascular system, such as diabetic nephropathy, neuropathy and retinopathy. Of these, diabetic retinopathy (DR) is the most common, and it remains a leading cause of vision loss in adults between the ages of 20-74.<br/><br/>Underlying these …
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Regulatory roles of endothelial cells in cancer
… in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view of tumor vessels from perfusing tubes to delivery platforms lined with potent paracrine regulatory cells. We focus on how the endothelial cells themselves regulate tumor biology in a …
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Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI
… a number of deleterious effects to the neurovascular system, including reduced cerebral blood flow (CBF), vascular regression, and ischemia, resulting in cognitive decline. Research into therapeutic targets to restore neurovascular function following injury has identified endothelial EphA4 …
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Peripheral arterial disease and diabetes: effects on endothelial progenitor cell differentiation and nitric oxide metabolism
… a progressive manifestation of atherothrombotic vascular disease, which results into the narrowing of the blood vessels of the lower limbs and, as final consequence, in critical leg ischemia. PAD often occurs along with other cardiovascular risk factors, including diabetes mellitus (DM), …